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• W3155424854 abstract "Abstract Development of an efficient, stereoselective, sustainable synthesis of chiral aryl β‐hydroxy α‐amino acids and their derivatives is of paramount importance, owing to the broad utility of these molecules in pharmaceutical application and asymmetric synthesis. We report a systematic study on ketoreductase (KRED)‐catalyzed dynamic reductive kinetic resolution (DYRKR) of aryl α‐amino β‐keto esters 6 , furnishing 20 structurally diverse chiral syn ‐aryl β‐hydroxy α‐amino esters ( syn ‐(2 S ,3 R )‐ 7 ) in moderate‐to‐excellent isolated yield (up to 93%), along with moderate‐to‐excellent diastereoselectivity (up to >99 : 1 dr) and excellent enantioselectivity (mostly >99% ee). The practical synthesis potential of our developed method was showcased by the asymmetric, chemo‐enzymatic total synthesis of thiamphenicol ( 1 )." @default.
• W3155424854 created "2021-04-26" @default.
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• W3155424854 date "2021-05-05" @default.
• W3155424854 modified "2023-10-16" @default.
• W3155424854 title "Enantio‐ and Diastereoselective Synthesis of Chiral <i>Syn</i> ‐Aryl β‐Hydroxy α‐Amino Esters via Biocatalytic Dynamic Reductive Kinetic Resolution" @default.
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• W3155424854 doi "https://doi.org/10.1002/ajoc.202100276" @default.
• W3155424854 hasPublicationYear "2021" @default.
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