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- W3155451876 abstract "Abstract Background Dietary constituents in certain bioactive substances may alleviate the toxicity of aflatoxin B 1 (AFB 1 ). Lycopene is a natural bioactive substance with powerful antioxidant, this study investigated whether dietary lycopene supplementation could alleviate AFB 1 -induced liver damage through inhibiting cytochrome P450 (CYP450) isozymes and improving detoxification and antioxidation with nuclear factor erythroid 2-related factor 2 (Nrf2) activation in broiler chickens. 320 healthy one-day-old male broiler chickens were randomly allotted into five groups and fed basal diet (Control), basal diet with AFB 1 and 0, 100, 200 or 400 mg/kg lycopene, respectively. At 42 days of age, 8 broiler chickens per group were sampled.Results Compared to the control group, AFB 1 -exposed birds had depressed growth performance, hepatotoxicity and oxidative damage. The various lycopene levels prevented AFB 1 -induced growth depression, decreased activities and mRNA expressions of hepatic CYP450 isozymes, reduced reactive oxygen species and oxidative damage products, improved reduced glutathione (GSH)-dependent detoxification system and antioxidant system. Moreover, lycopene elevated the mRNA expressions of Nrf2 and its target genes, containing glutathione-s-transferase isozymes, GSH synthesis-related enzymes and antioxidases in AFB 1 -exposed broiler chickens.Conclusions As an effective anti-stress and hepatoprotective antioxidant, lycopene alleviated AFB 1 -induced liver damage possibly through inhibiting CYP450 isozymes and improving Nrf2-mediated detoxification and antioxidant systems in broiler chickens. Therefore, Lycopene and lycopene-enriched materials could be taken into consideration as effective hepatoprotective and anti-stress additives in poultry, and benefit the resulting food safety." @default.
- W3155451876 created "2021-04-26" @default.
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- W3155451876 date "2020-05-08" @default.
- W3155451876 modified "2023-10-18" @default.
- W3155451876 title "Lycopene alleviates AFB1-induced liver damage possibly through inhibiting cytochrome 450 isozymes and improving Nrf2-miediated detoxification and antioxidant systems in broiler chickens" @default.
- W3155451876 doi "https://doi.org/10.21203/rs.3.rs-26864/v1" @default.
- W3155451876 hasPublicationYear "2020" @default.
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