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• W3155490096 abstract "Sickle cell disease (SCD) is an inherited hemoglobinopathy caused by a variant (rs344) in the HBB gene encoding the β-globin subunit of hemoglobin. Chronic hemolytic anemia and increased erythropoiesis and RBC turnover in individuals with SCD can result in increased needs for folate and other B-vitamins. We assessed B-vitamin status, and the distribution of folate forms, including unmetabolized folic acid (UMFA), in Canadian children with SCD supplemented with 1 mg/d folic acid (current routine practice). Non-fasted serum and plasma samples were analyzed for concentrations of folate, and vitamins B-2, B-6, and B-12. Eleven individuals (45% male; SCD type: HbSS n = 8, HbSC n = 2, HbSβ 0 -Thal n = 1), with a median (IQR) age of 14 (7, 18) years, were included. Total folate concentrations were 3–27 times above the deficiency cut-off (10 nmol/L), and 64% of children had elevated folate levels (&gt;45.3 nmol/L). UMFA (&gt;0.23 nmol/L) was detected in all children, and 36% of participants had elevated levels of UMFA (&gt;5.4 nmol/L). All children were vitamin B-12 sufficient (&gt;150 pmol/L), and the majority (55%) had sufficient B-6 status (&gt;30 nmol/L). Among this sample of Canadian children with SCD, there was limited evidence of B-vitamin deficiencies, but UMFA was detectable in all children." @default.
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• W3155490096 date "2021-04-21" @default.
• W3155490096 modified "2023-10-15" @default.
• W3155490096 title "Detectable Unmetabolized Folic Acid and Elevated Folate Concentrations in Folic Acid-Supplemented Canadian Children With Sickle Cell Disease" @default.
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• W3155490096 doi "https://doi.org/10.3389/fnut.2021.642306" @default.
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