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- W3155558715 abstract "CD1a, a lipid antigen-presenting molecule structurally related to MHC class I, is constitutively expressed on Langerhans cells in human epidermis. Studies in recent years have suggested a pathogenic role for CD1a in inflammatory and allergic skin disease. We have recently detected a subset of CD1a-restricted CD4+ T cells that specifically responds to bacterial phosphatidylglycerols. In particular, lysyl-phosphatidylglycerol (LPG), an aminoacylated membrane lipid present in many gram-positive bacteria, including S. aureus, binds to CD1a and is recognized by these T cells. Using CD1a tetramers loaded with LPG, we detected CD1a-LPG staining T cells in the peripheral blood of multiple donors, and were able to isolate and expand these T cells in vitro. The majority of tetramer+ T cells were CD4+ αβ T cells, and responded in a dose-dependent manner to LPG. CD1a-LPG reactive T cell lines showed a predominantly Th2 cytokine profile, with abundant IL-4 and IL-13 release. Beyond the recognition of purified lipid antigen, CD1a-LPG reactive T cells also responded to whole bacteria, as CD1a-expressing dendritic cells pre-incubated with S.aureus induced IL-13 release from the T cell lines. The increased bacterial skin colonization in atopic dermatitis (AD), specifically with S.aureus, prompted us to investigate the presence of CD1a-LPG reactive T cells in AD patients. A pilot study in atopic dermatitis patients and healthy controls showed a significantly increased frequency of CD4+ CD1a-LPG tetramer+ T cells in the blood of AD patients. Ongoing work aims to understand the contribution of CD1a-LPG reactive T cells to Th2 mediated pathology in AD." @default.
- W3155558715 created "2021-04-26" @default.
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- W3155558715 date "2021-05-01" @default.
- W3155558715 modified "2023-10-15" @default.
- W3155558715 title "035 Expansion of bacterial phosphatidylglycerol reactive CD4+ T cells in atopic dermatitis" @default.
- W3155558715 doi "https://doi.org/10.1016/j.jid.2021.02.051" @default.
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