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• W3155589735 startingPage "105608" @default.
• W3155589735 abstract "The past decade has seen many advancements in the development of three-dimensional (3D) in vitro models in pharmaceutical sciences and industry. Specifically, organoids present a self-organising, self-renewing and more physiologically relevant model than conventional two-dimensional (2D) cell cultures. Liver organoids have been developed from a variety of cell sources, including stem cells, cell lines and primary cells. They have potential for modelling patient-specific disease and establishing personalised therapeutic approaches. Additionally, liver organoids have been used to test drug efficacy and toxicity. Herein we summarise cell sources for generating liver organoids, the advantages and limitations of each cell type, as well as the application of the organoids in modelling liver diseases. We focus on the use of liver organoids as tools for drug validation and toxicity assessment." @default.
• W3155589735 created "2021-04-26" @default.
• W3155589735 creator A5026634194 @default.
• W3155589735 creator A5029715871 @default.
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• W3155589735 creator A5074850649 @default.
• W3155589735 creator A5087176957 @default.
• W3155589735 date "2021-07-01" @default.
• W3155589735 modified "2023-10-16" @default.
• W3155589735 title "Liver organoid as a 3D in vitro model for drug validation and toxicity assessment" @default.
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