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- W3155655310 abstract "Abstract This study was aimed to evaluate the potential of resveratrol (RES) to alleviate the adverse effects of aging in porcine oocytes through alleviating oxidative stress and up-regulating anti-apoptotic genes. Porcine oocytes were cultured in an in vitro medium supplemented with four levels (0, 1, 2, and 4 µmol/L) of RES. Based on initial screening; optimum RES level (2 µmol/L) was used to evaluate its potential effects on oocytes aged for 24 and 48 hours. Our results revealed that aged oocytes (24 h and 48 h) treated with RES showed higher (P < 0.05) ROS fluorescence intensity than the control group, but lower (P < 0.05) than untreated aged groups. The GSH content in untreated aged groups (24 h and 48 h) was lower (P < 0.05) than RES treated groups but both groups showed higher levels than the control. Similarly, the relative expression of antioxidant genes (CAT, GSH-Px, and SOD1) in RES treated groups was lower (P < 0.05) than the control group, but higher than untreated aged groups. Moreover, the relative mRNA expression of caspase-3 and Bax in RES treated groups was higher (P < 0.05) than the control group but lower than untreated groups. Furthermore, the expression of Bcl-2 in the RES treated group was significantly lower than control but higher than untreated aged groups. Our findings revealed that the RES can increase the activity of antioxidant enzymes while decreasing the level of ROS in porcine aged oocytes. Moreover, RES showed its potent anti-apoptotic effects and potentially resisted against the decline in mitochondrial membrane potential in aged oocytes." @default.
- W3155655310 created "2021-04-26" @default.
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- W3155655310 date "2020-12-03" @default.
- W3155655310 modified "2023-10-18" @default.
- W3155655310 title "Resveratrol Can Revert Adverse Effects of Oocyte aging in Pig" @default.
- W3155655310 doi "https://doi.org/10.21203/rs.3.rs-120271/v1" @default.
- W3155655310 hasPublicationYear "2020" @default.
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