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- W3155655377 abstract "Abstract Conduct disorder (CD), characterized by youth antisocial behavior, is associated with a variety of neurocognitive impairments. However, questions remain regarding the neural underpinnings of these impairments. To investigate novel neural mechanisms that may support these neurocognitive abnormalities, the present study applied a graph analysis to resting-state functional magnetic resonance imaging (fMRI) data collected from a national sample of 4,781 youth, ages 9–10, who participated in the baseline session of the Adolescent Brain Cognitive Development SM Study (ABCD Study®). Analyses were then conducted to examine the relationships among levels of CD symptomatology, metrics of global topology, node-level metrics for subcortical structures, and performance on neurocognitive assessments. Youth higher on CD displayed higher global clustering (β = .039, 95% CI corrected [.0027 .0771]), but lower Degree subcortical (β = −.052, 95% CI corrected [−.0916 −.0152]). Youth higher on CD had worse performance on a general neurocognitive assessment (β = −.104, 95% CI [−.1328 −.0763]) and an emotion recognition memory assessment (β = −.061, 95% CI [−.0919 −.0290]). Finally, global clustering mediated the relationship between CD and general neurocognitive functioning (indirect β = −.002, 95% CI [−.0044 −.0002]), and Degree subcortical mediated the relationship between CD and emotion recognition memory performance (indirect β = −.002, 95% CI [−.0046 −.0005]). CD appears associated with neuro-topological abnormalities and these abnormalities may represent neural mechanisms supporting CD-related neurocognitive disruptions." @default.
- W3155655377 created "2021-04-26" @default.
- W3155655377 creator A5014000601 @default.
- W3155655377 creator A5020403439 @default.
- W3155655377 creator A5027161218 @default.
- W3155655377 date "2021-04-14" @default.
- W3155655377 modified "2023-09-26" @default.
- W3155655377 title "Conduct disorder symptomatology is associated with an altered functional connectome in a large national youth sample" @default.
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- W3155655377 doi "https://doi.org/10.1017/s0954579421000237" @default.
- W3155655377 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33851904" @default.
- W3155655377 hasPublicationYear "2021" @default.