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• W3155655893 abstract "Cardiovascular effects of glucagon-like peptide-1 receptor (GLP-1R) agonist therapies are potentially mediated by anti-inflammatory effects on atherosclerosis. Our study demonstrates that 68 Ga-NODAGA-exendin-4, a radioligand specifically targeting GLP-1R, detects GLP-1R expression in inflamed atherosclerotic lesions in nondiabetic and diabetic hypercholesterolemic mice. Immunofluorescence staining suggests that GLP-1R is primarily localized in M2 macrophages in lesions. This study describes a new potential tool that may have translational relevance for studies of pharmacological modification of GLP-1R signaling in atherosclerosis." @default.
• W3155655893 created "2021-04-26" @default.
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• W3155655893 date "2021-05-01" @default.
• W3155655893 modified "2023-10-17" @default.
• W3155655893 title "Evaluation of glucagon-like peptide-1 receptor expression in nondiabetic and diabetic atherosclerotic mice using PET tracer ⁶⁸Ga-NODAGA-exendin-4" @default.
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• W3155655893 doi "https://doi.org/10.1152/ajpendo.00465.2020" @default.
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