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• W3155693531 endingPage "2894" @default.
• W3155693531 startingPage "2851" @default.
• W3155693531 abstract "Regulation of emotions is generally associated exclusively with the brain. However, there is evidence that peripheral systems are also involved in mood, stress vulnerability vs. resilience, and emotion-related memory encoding. Prevalence of stress and mood disorders such as major depression, bipolar disorder, and post-traumatic stress disorder is increasing in our modern societies. Unfortunately, 30%-50% of individuals respond poorly to currently available treatments highlighting the need to further investigate emotion-related biology to gain mechanistic insights that could lead to innovative therapies. Here, we provide an overview of inflammation-related mechanisms involved in mood regulation and stress responses discovered using animal models. If clinical studies are available, we discuss translational value of these findings including limitations. Neuroimmune mechanisms of depression and maladaptive stress responses have been receiving increasing attention, and thus, the first part is centered on inflammation and dysregulation of brain and circulating cytokines in stress and mood disorders. Next, recent studies supporting a role for inflammation-driven leakiness of the blood-brain and gut barriers in emotion regulation and mood are highlighted. Stress-induced exacerbated inflammation fragilizes these barriers which become hyperpermeable through loss of integrity and altered biology. At the gut level, this could be associated with dysbiosis, an imbalance in microbial communities, and alteration of the gut-brain axis which is central to production of mood-related neurotransmitter serotonin. Novel therapeutic approaches such as anti-inflammatory drugs, the fast-acting antidepressant ketamine, and probiotics could directly act on the mechanisms described here improving mood disorder-associated symptomatology. Discovery of biomarkers has been a challenging quest in psychiatry, and we end by listing promising targets worth further investigation." @default.
• W3155693531 created "2021-04-26" @default.
• W3155693531 creator A5011910262 @default.
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• W3155693531 creator A5040225479 @default.
• W3155693531 creator A5062929009 @default.
• W3155693531 creator A5087528342 @default.
• W3155693531 date "2021-05-17" @default.
• W3155693531 modified "2023-10-17" @default.
• W3155693531 title "Inflammation‐driven brain and gut barrier dysfunction in stress and mood disorders" @default.
• W3155693531 cites W105790761 @default.
• W3155693531 cites W1155976162 @default.
• W3155693531 cites W1197974428 @default.
• W3155693531 cites W1247495967 @default.
• W3155693531 cites W130054925 @default.
• W3155693531 cites W1483124963 @default.
• W3155693531 cites W1511619400 @default.
• W3155693531 cites W1515023627 @default.
• W3155693531 cites W1518127352 @default.
• W3155693531 cites W1543895408 @default.
• W3155693531 cites W1552089776 @default.
• W3155693531 cites W1600219138 @default.
• W3155693531 cites W1603640418 @default.
• W3155693531 cites W162706120 @default.
• W3155693531 cites W1697553032 @default.
• W3155693531 cites W1698622206 @default.
• W3155693531 cites W1757453904 @default.
• W3155693531 cites W1768927256 @default.
• W3155693531 cites W1833405892 @default.
• W3155693531 cites W1877874306 @default.
• W3155693531 cites W1892932767 @default.
• W3155693531 cites W1897972863 @default.
• W3155693531 cites W1904080427 @default.
• W3155693531 cites W1920246049 @default.
• W3155693531 cites W1955944566 @default.
• W3155693531 cites W1963708297 @default.
• W3155693531 cites W1966702654 @default.
• W3155693531 cites W1966776937 @default.
• W3155693531 cites W1967944820 @default.
• W3155693531 cites W1968731032 @default.
• W3155693531 cites W1969388943 @default.
• W3155693531 cites W1969866879 @default.
• W3155693531 cites W1971051809 @default.
• W3155693531 cites W1971295949 @default.
• W3155693531 cites W1972330598 @default.
• W3155693531 cites W1973048800 @default.
• W3155693531 cites W1973172818 @default.
• W3155693531 cites W1973835204 @default.
• W3155693531 cites W1974820251 @default.
• W3155693531 cites W1975015162 @default.
• W3155693531 cites W1977430165 @default.
• W3155693531 cites W1977593923 @default.
• W3155693531 cites W1977804070 @default.
• W3155693531 cites W1979091134 @default.
• W3155693531 cites W1982380873 @default.
• W3155693531 cites W1984103995 @default.
• W3155693531 cites W1984336722 @default.
• W3155693531 cites W1985005182 @default.
• W3155693531 cites W1985953232 @default.
• W3155693531 cites W1988107159 @default.
• W3155693531 cites W1988209307 @default.
• W3155693531 cites W1988970114 @default.
• W3155693531 cites W1989435867 @default.
• W3155693531 cites W1989493776 @default.
• W3155693531 cites W1990151307 @default.
• W3155693531 cites W1991056345 @default.
• W3155693531 cites W1991521547 @default.
• W3155693531 cites W1991830749 @default.
• W3155693531 cites W1995213118 @default.
• W3155693531 cites W1995239836 @default.
• W3155693531 cites W1998585277 @default.
• W3155693531 cites W1999332376 @default.
• W3155693531 cites W1999604712 @default.
• W3155693531 cites W2000055713 @default.
• W3155693531 cites W2000209446 @default.
• W3155693531 cites W2000422049 @default.
• W3155693531 cites W2002167576 @default.
• W3155693531 cites W2002684730 @default.
• W3155693531 cites W2003081532 @default.
• W3155693531 cites W2003263043 @default.
• W3155693531 cites W2003342633 @default.
• W3155693531 cites W2003831663 @default.
• W3155693531 cites W2003982930 @default.
• W3155693531 cites W2005471473 @default.
• W3155693531 cites W2006245117 @default.
• W3155693531 cites W2007275553 @default.
• W3155693531 cites W2007353040 @default.
• W3155693531 cites W2007811606 @default.
• W3155693531 cites W2009730192 @default.
• W3155693531 cites W2012121005 @default.
• W3155693531 cites W2012518663 @default.
• W3155693531 cites W2012741273 @default.
• W3155693531 cites W2013756862 @default.
• W3155693531 cites W2014858274 @default.
• W3155693531 cites W2016216215 @default.
• W3155693531 cites W2016575029 @default.
• W3155693531 cites W2017441041 @default.
• W3155693531 cites W2018821577 @default.

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