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- W3155756670 abstract "Ketogenic diets (KDs) are reported to improve body weight, fat mass, and exercise performance in humans. Unfortunately, most rodent studies have used a low-protein KD, which does not recapitulate diets used by humans. Since skeletal muscle plays a critical role in responding to macronutrient perturbations induced by diet and exercise, the purpose of this study was to test if a normal-protein KD (NPKD) impacts shifts in skeletal muscle substrate oxidative capacity in response to exercise training (ExTr). A high fat, carbohydrate-deficient NPKD (16.1% protein, 83.9% fat, 0% carbohydrate) was given to C57BL/6J male mice for 6 wk, whereas controls (Con) received a low-fat diet with similar protein (15.9% protein, 11.9% fat, 72.2% carbohydrate). After 3 wk on the diet, mice began treadmill training 5 days/wk, 60 min/day for 3 wks. The NPKD increased body weight and fat mass, whereas ExTr negated a continued rise in adiposity. ExTr increased intramuscular glycogen, whereas the NPKD increased intramuscular triglycerides. Neither the NPKD nor ExTr alone altered mitochondrial content; however, in combination, the NPKD-ExTr group showed increases in PGC-1α and markers of mitochondrial fission/fusion. Pyruvate oxidative capacity was unchanged by either intervention, whereas ExTr increased leucine oxidation in NPKD-fed mice. Lipid metabolism pathways had the most notable changes as the NPKD and ExTr interventions both enhanced mitochondrial and peroxisomal lipid oxidation and many adaptations were additive or synergistic. Overall, these results suggest that a combination of a NPKD and ExTr induces additive and/or synergistic adaptations in skeletal muscle oxidative capacity.NEW & NOTEWORTHY A ketogenic diet with normal protein content (NPKD) increases body weight and fat mass, increases intramuscular triglyceride storage, and upregulates pathways related to protein metabolism. In combination with exercise training, a NPKD induces additive and/or synergistic activation of AMPK, PGC-1α, mitochondrial fission/fusion genes, mitochondrial fatty acid oxidation, and peroxisomal adaptations in skeletal muscle. Collectively, results from this study provide mechanistic insight into adaptations in skeletal muscle relevant to keto-adaptation." @default.
- W3155756670 created "2021-04-26" @default.
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- W3155756670 date "2021-06-01" @default.
- W3155756670 modified "2023-10-10" @default.
- W3155756670 title "Combined effects of a ketogenic diet and exercise training alter mitochondrial and peroxisomal substrate oxidative capacity in skeletal muscle" @default.
- W3155756670 cites W1516172702 @default.
- W3155756670 cites W1601325022 @default.
- W3155756670 cites W1622316680 @default.
- W3155756670 cites W1623884054 @default.
- W3155756670 cites W1813900177 @default.
- W3155756670 cites W1847779613 @default.
- W3155756670 cites W1939241225 @default.
- W3155756670 cites W1971082641 @default.
- W3155756670 cites W1981057948 @default.
- W3155756670 cites W1992295816 @default.
- W3155756670 cites W1995381409 @default.
- W3155756670 cites W2002094413 @default.
- W3155756670 cites W2006153700 @default.
- W3155756670 cites W2014671368 @default.
- W3155756670 cites W2015189880 @default.
- W3155756670 cites W2019455536 @default.
- W3155756670 cites W2032640518 @default.
- W3155756670 cites W2041805176 @default.
- W3155756670 cites W2042589899 @default.
- W3155756670 cites W2046115241 @default.
- W3155756670 cites W2050255900 @default.
- W3155756670 cites W2062699862 @default.
- W3155756670 cites W2065278560 @default.
- W3155756670 cites W2066194653 @default.
- W3155756670 cites W2069746351 @default.
- W3155756670 cites W2077645437 @default.
- W3155756670 cites W2080687097 @default.
- W3155756670 cites W2088262190 @default.
- W3155756670 cites W2093181249 @default.
- W3155756670 cites W2097144818 @default.
- W3155756670 cites W2104655808 @default.
- W3155756670 cites W2107520997 @default.
- W3155756670 cites W2123352794 @default.
- W3155756670 cites W2127411784 @default.
- W3155756670 cites W2130919437 @default.
- W3155756670 cites W2133844993 @default.
- W3155756670 cites W2135342641 @default.
- W3155756670 cites W2140313261 @default.
- W3155756670 cites W2140558936 @default.
- W3155756670 cites W2142716760 @default.
- W3155756670 cites W2143112776 @default.
- W3155756670 cites W2149866248 @default.
- W3155756670 cites W2156516623 @default.
- W3155756670 cites W2156565014 @default.
- W3155756670 cites W2160524748 @default.
- W3155756670 cites W2166658566 @default.
- W3155756670 cites W2166979654 @default.
- W3155756670 cites W2169469988 @default.
- W3155756670 cites W2170065584 @default.
- W3155756670 cites W2179277279 @default.
- W3155756670 cites W2287560945 @default.
- W3155756670 cites W2476262144 @default.
- W3155756670 cites W2482292220 @default.
- W3155756670 cites W2503267861 @default.
- W3155756670 cites W2517910168 @default.
- W3155756670 cites W2543080048 @default.
- W3155756670 cites W2556344533 @default.
- W3155756670 cites W2562509757 @default.
- W3155756670 cites W2565236461 @default.
- W3155756670 cites W2568957122 @default.
- W3155756670 cites W2589199552 @default.
- W3155756670 cites W2614352140 @default.
- W3155756670 cites W2623985649 @default.
- W3155756670 cites W2755598184 @default.
- W3155756670 cites W2788898766 @default.
- W3155756670 cites W2790087708 @default.
- W3155756670 cites W2804558668 @default.
- W3155756670 cites W2887071106 @default.
- W3155756670 cites W2890976135 @default.
- W3155756670 cites W2892119900 @default.
- W3155756670 cites W2896393935 @default.
- W3155756670 cites W2900758386 @default.
- W3155756670 cites W2901445004 @default.
- W3155756670 cites W2942692922 @default.
- W3155756670 cites W2945024704 @default.
- W3155756670 cites W2946204743 @default.
- W3155756670 cites W2950248656 @default.
- W3155756670 cites W2965864182 @default.
- W3155756670 cites W2969196443 @default.
- W3155756670 cites W2980515248 @default.
- W3155756670 cites W2988464790 @default.
- W3155756670 cites W2996221567 @default.
- W3155756670 cites W3024923506 @default.