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- W3155759366 abstract "In recent years, coumarin fluorescent probes have been widely used in the detection of environmental pollutants, disease diagnosis and drug development due to their excellent optical properties, good water solubility and easy structure modification. Most coumarin fluorescent probes are modified at 3 and 7 positions mainly by introducing substituents, while at 4 and 8 positions are relatively less modified. Herein, compound 2 and 3 were prepared by introducing electron-donating group (EDG) and electron-withdrawing group (EWG) into the 4 position of 7-diethylamino-3-acetyl coumarin, respectively, and their properties were studied by theoretical calculation and spectral test. Then, we successfully prepared Probe 1 and Probe 2 by introducing pyrazoline ring at 7 position. Probe 2 exhibited high quantum yield and rapid response to ClO− in pure PBS. We speculated that it is a synergistic action of –OH and pyrazoline rings. In addition, Probe 2 could effectively detect ClO− in HeLa cells and zebrafish. Modification of substituents in different positions is a novel concept for the construction and optimization of fluorescent probes, which will provide a more effective tool for solving practical problems." @default.
- W3155759366 created "2021-04-26" @default.
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- W3155759366 date "2021-07-01" @default.
- W3155759366 modified "2023-10-12" @default.
- W3155759366 title "An innovative hypochlorite-sensing scaffold and its imaging application in vivo" @default.
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- W3155759366 doi "https://doi.org/10.1016/j.dyepig.2021.109378" @default.
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