FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3155764721> ?p ?o ?g. }

• W3155764721 abstract "Abstract Background Patients with Ehlers-Danlos Syndrome/Hypermobility Type (EDS-HT/JHS) and Craneo-Cervical Instability frequently suffer from severe widespread pain which is difficult to control. Chronic neuroinflammation, opioid-induced hyperalgesia, and central sensitization may explain this painful condition. The aim of this study was to determine if opioid-free anesthesia plus the postoperative administration of lidocaine, ketamine and dexmedetomidine can reduce postoperative pain and the need of methadone rescues in comparison with opioid-based management in these patients undergoing Craneo-Cervical Fixation (CCF). The secondary aim was to assess the needs of opioids at hospital-discharge, incidence of gastrointestinal complications and the requirement of anxiolytic. Methods A retrospective, consecutive case series study was designed. 42 patients with EDS-HT/JHS undergoing CCF were enrolled in two groups: an OFA-plus Group that received opioid-free anesthesia with propofol, lidocaine, ketamine and dexmedetomidine, and OP Group, opioid-based anesthesia-analgesia. The main variables: Preoperative Visual Analogue Score (VAS), postoperative VAS on the 1st, 2nd, 4th and 6th days, sufentanil or morphine requirements, need for methadone rescue, and VAS at hospital-discharge. Data was presented by mean ± SD, percentage, median or interquartile range. Chi-squared or Fisher’s test. 95% C.I and P values < 0.05. Results Nineteen patients in OFA-plus, and 23 patients in OP group. VAS was lower in OFA-plus on the postoperative days evaluated ( p < 0.001).VAS at hospital-discharge was lower in OFA-plus: 4.96 (4.54–5.37) vs. OP 6.39 (6.07–6.71) ( p < 0.001). Methadone requirement was lower in the OFA-plus ( p < 0.001). 78% of patients in OFA-plus didn’t need methadone rescue. 95% in OP group needed methadone rescues at high doses(> 15 mg/day). No differences regarding equivalent doses of sufentanil or morphine consumption on the 2nd, 4th, and 6th postoperative days were found. OFA-plus decreased ileus, nausea and vomiting ( p < 0.001). 60.9% in OFA-plus group decreased opioid requirements at hospital-discharge compared with preoperative values. A 77% reduction of anxiolytics requirements was shown. Conclusion OFA-plus management for patients undergoing CCF with EDS-HT/JHS shows significant reduction in postoperative pain and at hospital-discharge compared with opioid-based anesthesia. OFA-plus management decreases the total doses of methadone rescues, reduces anxiolytic requirements and gastrointestinal side-effects, except for constipation. OFA-plus management is a feasible option to improve postoperative pain control, reducing the opioids’ use and their postoperative side-effects in patients undergoing CCF with EDS-HT/JHS." @default.
• W3155764721 created "2021-04-26" @default.
• W3155764721 creator A5001556987 @default.
• W3155764721 creator A5008286749 @default.
• W3155764721 creator A5008692313 @default.
• W3155764721 creator A5017797452 @default.
• W3155764721 creator A5023537008 @default.
• W3155764721 creator A5026556656 @default.
• W3155764721 creator A5029590364 @default.
• W3155764721 creator A5057590628 @default.
• W3155764721 creator A5068545013 @default.
• W3155764721 creator A5087383476 @default.
• W3155764721 creator A5091912738 @default.
• W3155764721 date "2021-04-13" @default.
• W3155764721 modified "2023-10-18" @default.
• W3155764721 title "Opioid-free anesthesia for patients with joint hypermobility syndrome undergoing craneo-cervical fixation: a case-series study focused on anti-hyperalgesic approach" @default.
• W3155764721 cites W1189044808 @default.
• W3155764721 cites W2004608514 @default.
• W3155764721 cites W2113977532 @default.
• W3155764721 cites W2125671016 @default.
• W3155764721 cites W2144694293 @default.
• W3155764721 cites W2155786560 @default.
• W3155764721 cites W2161298308 @default.
• W3155764721 cites W2179737063 @default.
• W3155764721 cites W2197394318 @default.
• W3155764721 cites W2341174219 @default.
• W3155764721 cites W2388981369 @default.
• W3155764721 cites W2396131816 @default.
• W3155764721 cites W2537532244 @default.
• W3155764721 cites W2605900660 @default.
• W3155764721 cites W2610582348 @default.
• W3155764721 cites W2618573340 @default.
• W3155764721 cites W2737934651 @default.
• W3155764721 cites W2766251233 @default.
• W3155764721 cites W2786697307 @default.
• W3155764721 cites W2891868538 @default.
• W3155764721 cites W2898719487 @default.
• W3155764721 cites W2910991264 @default.
• W3155764721 cites W2917511632 @default.
• W3155764721 cites W2931549162 @default.
• W3155764721 cites W2935871715 @default.
• W3155764721 cites W2937415624 @default.
• W3155764721 cites W2944402867 @default.
• W3155764721 cites W2954018937 @default.
• W3155764721 cites W3003449252 @default.
• W3155764721 cites W3010877895 @default.
• W3155764721 cites W1976931151 @default.
• W3155764721 doi "https://doi.org/10.1186/s13023-021-01795-4" @default.
• W3155764721 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8045305" @default.
• W3155764721 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33849631" @default.
• W3155764721 hasPublicationYear "2021" @default.
• W3155764721 type Work @default.
• W3155764721 sameAs 3155764721 @default.
• W3155764721 citedByCount "5" @default.
• W3155764721 countsByYear W31557647212022 @default.
• W3155764721 countsByYear W31557647212023 @default.
• W3155764721 crossrefType "journal-article" @default.
• W3155764721 hasAuthorship W3155764721A5001556987 @default.
• W3155764721 hasAuthorship W3155764721A5008286749 @default.
• W3155764721 hasAuthorship W3155764721A5008692313 @default.
• W3155764721 hasAuthorship W3155764721A5017797452 @default.
• W3155764721 hasAuthorship W3155764721A5023537008 @default.
• W3155764721 hasAuthorship W3155764721A5026556656 @default.
• W3155764721 hasAuthorship W3155764721A5029590364 @default.
• W3155764721 hasAuthorship W3155764721A5057590628 @default.
• W3155764721 hasAuthorship W3155764721A5068545013 @default.
• W3155764721 hasAuthorship W3155764721A5087383476 @default.
• W3155764721 hasAuthorship W3155764721A5091912738 @default.
• W3155764721 hasBestOaLocation W31557647211 @default.
• W3155764721 hasConcept C126322002 @default.
• W3155764721 hasConcept C141071460 @default.
• W3155764721 hasConcept C170493617 @default.
• W3155764721 hasConcept C2776277131 @default.
• W3155764721 hasConcept C2776814716 @default.
• W3155764721 hasConcept C2778767360 @default.
• W3155764721 hasConcept C2778891214 @default.
• W3155764721 hasConcept C2780795376 @default.
• W3155764721 hasConcept C2781063702 @default.
• W3155764721 hasConcept C2781302539 @default.
• W3155764721 hasConcept C42219234 @default.
• W3155764721 hasConcept C71924100 @default.
• W3155764721 hasConceptScore W3155764721C126322002 @default.
• W3155764721 hasConceptScore W3155764721C141071460 @default.
• W3155764721 hasConceptScore W3155764721C170493617 @default.
• W3155764721 hasConceptScore W3155764721C2776277131 @default.
• W3155764721 hasConceptScore W3155764721C2776814716 @default.
• W3155764721 hasConceptScore W3155764721C2778767360 @default.
• W3155764721 hasConceptScore W3155764721C2778891214 @default.
• W3155764721 hasConceptScore W3155764721C2780795376 @default.
• W3155764721 hasConceptScore W3155764721C2781063702 @default.
• W3155764721 hasConceptScore W3155764721C2781302539 @default.
• W3155764721 hasConceptScore W3155764721C42219234 @default.
• W3155764721 hasConceptScore W3155764721C71924100 @default.
• W3155764721 hasIssue "1" @default.
• W3155764721 hasLocation W31557647211 @default.
• W3155764721 hasLocation W31557647212 @default.
• W3155764721 hasLocation W31557647213 @default.
• W3155764721 hasOpenAccess W3155764721 @default.
• W3155764721 hasPrimaryLocation W31557647211 @default.
• W3155764721 hasRelatedWork W2072987602 @default.

• next