FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3155787777> ?p ?o ?g. }

• W3155787777 endingPage "6005" @default.
• W3155787777 startingPage "5986" @default.
• W3155787777 abstract "Oxidative stress is a critical event in neuronal damage following seizures. Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) have been shown to be promising nanotherapeutic agents in neurological disorders. However, the mechanism underlying MSC-EVs therapeutic efficacy for oxidative stress-induced neuronal damage remains poorly understood. Methods: We investigated the antioxidant and restoration activities of MSC-EVs on hippocampal neurons in response to H2O2 stimulation in vitro and seizures in vivo. We also explored the potential underlying mechanism by injecting adeno-associated virus (AAV)-nuclear factor erythroid-derived 2, like 2 (Nrf2), a key antioxidant mediator, in animal models. Results: MSC-EVs were enriched in antioxidant miRNAs and exhibited remarkable antioxidant activity evident by increased ferric ion-reducing antioxidant ability, catalase, superoxide dismutase, and glutathione peroxidase activities and decreased reactive oxygen species (ROS) generation, DNA/lipid/protein oxidation, and stress-associated molecular patterns in cultured cells and mouse models. Notably, EV administration exerted restorative effects on the hippocampal neuronal structure and associated functional impairments, including dendritic spine alterations, electrophysiological disturbances, calcium transients, mitochondrial changes, and cognitive decline after oxidative stress in vitro or in vivo. Mechanistically, we found that the Nrf2 signaling pathway was involved in the restorative effect of EV therapy against oxidative neuronal damage, while AAV-Nrf2 injection attenuated the antioxidant activity of MSC-EVs on the seizure-induced hippocampal injury. Conclusions: We have shown that MSC-EVs facilitate the reconstruction of hippocampal neurons associated with the Nrf2 defense system in response to oxidative insults. Our study highlights the clinical value of EV-therapy in neurological disorders such as seizures." @default.
• W3155787777 created "2021-04-26" @default.
• W3155787777 creator A5024419320 @default.
• W3155787777 creator A5027808666 @default.
• W3155787777 creator A5032397876 @default.
• W3155787777 creator A5034865615 @default.
• W3155787777 creator A5048813458 @default.
• W3155787777 creator A5056168495 @default.
• W3155787777 creator A5058154527 @default.
• W3155787777 creator A5068274975 @default.
• W3155787777 creator A5073189098 @default.
• W3155787777 creator A5083932487 @default.
• W3155787777 creator A5084854649 @default.
• W3155787777 creator A5086133293 @default.
• W3155787777 date "2021-01-01" @default.
• W3155787777 modified "2023-10-11" @default.
• W3155787777 title "Antioxidant activity of mesenchymal stem cell-derived extracellular vesicles restores hippocampal neurons following seizure damage" @default.
• W3155787777 cites W1482023004 @default.
• W3155787777 cites W1485297825 @default.
• W3155787777 cites W1537540865 @default.
• W3155787777 cites W1798313689 @default.
• W3155787777 cites W1875115860 @default.
• W3155787777 cites W1958394803 @default.
• W3155787777 cites W1977052540 @default.
• W3155787777 cites W1988103013 @default.
• W3155787777 cites W1990737844 @default.
• W3155787777 cites W1992086461 @default.
• W3155787777 cites W1993050097 @default.
• W3155787777 cites W2012740696 @default.
• W3155787777 cites W2018659142 @default.
• W3155787777 cites W2026570544 @default.
• W3155787777 cites W2029085000 @default.
• W3155787777 cites W2068022080 @default.
• W3155787777 cites W2070292694 @default.
• W3155787777 cites W2080418767 @default.
• W3155787777 cites W2091036726 @default.
• W3155787777 cites W2100741632 @default.
• W3155787777 cites W2105089616 @default.
• W3155787777 cites W2108471384 @default.
• W3155787777 cites W2147537019 @default.
• W3155787777 cites W2149622421 @default.
• W3155787777 cites W2149938392 @default.
• W3155787777 cites W2155852776 @default.
• W3155787777 cites W2161220011 @default.
• W3155787777 cites W2168271032 @default.
• W3155787777 cites W2204697639 @default.
• W3155787777 cites W2218210464 @default.
• W3155787777 cites W2296699107 @default.
• W3155787777 cites W2340867627 @default.
• W3155787777 cites W2535730691 @default.
• W3155787777 cites W2606603228 @default.
• W3155787777 cites W2616365807 @default.
• W3155787777 cites W2617594540 @default.
• W3155787777 cites W2619641984 @default.
• W3155787777 cites W2782691869 @default.
• W3155787777 cites W2789802139 @default.
• W3155787777 cites W2791934000 @default.
• W3155787777 cites W2794115153 @default.
• W3155787777 cites W2794133709 @default.
• W3155787777 cites W2794946498 @default.
• W3155787777 cites W2803750405 @default.
• W3155787777 cites W2807919650 @default.
• W3155787777 cites W2889236268 @default.
• W3155787777 cites W2901891565 @default.
• W3155787777 cites W2905083850 @default.
• W3155787777 cites W2909519514 @default.
• W3155787777 cites W2911761011 @default.
• W3155787777 cites W2912076408 @default.
• W3155787777 cites W2913892920 @default.
• W3155787777 cites W2914059557 @default.
• W3155787777 cites W2914833536 @default.
• W3155787777 cites W2953960051 @default.
• W3155787777 cites W2970893919 @default.
• W3155787777 cites W2972804872 @default.
• W3155787777 cites W2982201217 @default.
• W3155787777 cites W2996854824 @default.
• W3155787777 cites W3005104290 @default.
• W3155787777 cites W3007776476 @default.
• W3155787777 cites W3028089603 @default.
• W3155787777 cites W3046128473 @default.
• W3155787777 cites W3046836243 @default.
• W3155787777 cites W3047434011 @default.
• W3155787777 doi "https://doi.org/10.7150/thno.58632" @default.
• W3155787777 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8058724" @default.
• W3155787777 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33897894" @default.
• W3155787777 hasPublicationYear "2021" @default.
• W3155787777 type Work @default.
• W3155787777 sameAs 3155787777 @default.
• W3155787777 citedByCount "24" @default.
• W3155787777 countsByYear W31557877772021 @default.
• W3155787777 countsByYear W31557877772022 @default.
• W3155787777 countsByYear W31557877772023 @default.
• W3155787777 crossrefType "journal-article" @default.
• W3155787777 hasAuthorship W3155787777A5024419320 @default.
• W3155787777 hasAuthorship W3155787777A5027808666 @default.
• W3155787777 hasAuthorship W3155787777A5032397876 @default.
• W3155787777 hasAuthorship W3155787777A5034865615 @default.
• W3155787777 hasAuthorship W3155787777A5048813458 @default.

• next