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• W3155880892 abstract "Pyroglutamate aminopeptidase (PGP) specifically cleaves the peptide bond of pyroglutamic acid linked to the N-terminal end of a polypeptide or protein. Previous studies showed that PGP was associated with several physiological processes and diseases especially those involving inflammation. Utilizing a 'caging' strategy, we designed and synthesized a bioluminescence probe (PBL) with a limit-of-detection of 3.7 * 10-4 mU/mL. In vivo imaging in a mouse model of inflammatory liver disease revealed that the probe has excellent sensitivity and selectivity and provides a powerful tool for studying the physiological and pathological processes involving PGP." @default.
• W3155880892 created "2021-04-26" @default.
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• W3155880892 date "2021-07-01" @default.
• W3155880892 modified "2023-09-26" @default.
• W3155880892 title "A bioluminescent probe for in vivo imaging of pyroglutamate aminopeptidase in a mouse model of inflammation" @default.
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• W3155880892 doi "https://doi.org/10.1016/j.bmcl.2021.128049" @default.
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