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- W3155966706 abstract "Alzheimer's disease (AD) is the inoperable, incapacitating, neuropsychiatric, and degenerative manifestation that drastically affects human life quality. The current medications target extra-neuronal senile plaques, oxidative stress, neuroinflammation, intraneuronal neurofibrillary tangles, cholinergic deficits, and excitotoxicity. Among novel pathways and targets, bioenergetic and resultant mitochondrial dysfunction has been recognized as essential factors that decide the neuronal fate and consequent neurodegeneration in AD. The crucial attributes of mitochondria, including bioenergesis, signaling, sensing, integrating, and transmitting biological signals contribute to optimum networking of neuronal dynamics and make them indispensable for cell survival. In AD, mitochondrial dysfunction and mitophagy are a preliminary and critical event that aggravates the pathological cascade. Stress is known to promote and exaggerate the neuropathological alteration during neurodegeneration and metabolic impairments, especially in the cortico-limbic system, besides adversely affecting the normal physiology and mitochondrial dynamics. Stress involves the allocation of energy resources for neuronal survival. Chronic and aggravated stress response leads to excessive release of glucocorticoids by activation of the hypothalamic-pituitaryadrenal (HPA) axis. By acting through their receptors, glucocorticoids influence adverse mitochondrial changes and alter mtDNA transcription, mtRNA expression, hippocampal mitochondrial network, and ultimately mitochondrial physiology. Chronic stress also affects mitochondrial dynamics by changing metabolic and neuro-endocrinal signalling, aggravating oxidative stress, provoking inflammatory mediators, altering tropic factors, influencing gene expression, and modifying epigenetic pathways. Thus, exploring chronic stress-induced glucocorticoid dysregulation and resultant bio-behavioral and psychosomatic mitochondrial alterations may be a feasible narrative to investigate and unravel the mysterious pathobiology of AD." @default.
- W3155966706 created "2021-04-26" @default.
- W3155966706 creator A5016919399 @default.
- W3155966706 creator A5027544487 @default.
- W3155966706 creator A5082715070 @default.
- W3155966706 date "2021-07-01" @default.
- W3155966706 modified "2023-10-10" @default.
- W3155966706 title "Stressed mitochondria: A target to intrude alzheimer’s disease" @default.
- W3155966706 cites W139355624 @default.
- W3155966706 cites W153393150 @default.
- W3155966706 cites W1548760166 @default.
- W3155966706 cites W1867998771 @default.
- W3155966706 cites W1919353 @default.
- W3155966706 cites W1966995952 @default.
- W3155966706 cites W1967888239 @default.
- W3155966706 cites W1974323299 @default.
- W3155966706 cites W1982520634 @default.
- W3155966706 cites W1982900915 @default.
- W3155966706 cites W1988664434 @default.
- W3155966706 cites W1989555730 @default.
- W3155966706 cites W1999069234 @default.
- W3155966706 cites W1999924432 @default.
- W3155966706 cites W2003975298 @default.
- W3155966706 cites W2004254712 @default.
- W3155966706 cites W2022812113 @default.
- W3155966706 cites W2031353556 @default.
- W3155966706 cites W2031918149 @default.
- W3155966706 cites W2033077860 @default.
- W3155966706 cites W2033603289 @default.
- W3155966706 cites W2044171033 @default.
- W3155966706 cites W2045928883 @default.
- W3155966706 cites W2047460306 @default.
- W3155966706 cites W2049814665 @default.
- W3155966706 cites W2057147625 @default.
- W3155966706 cites W2058972802 @default.
- W3155966706 cites W2062131882 @default.
- W3155966706 cites W2073861762 @default.
- W3155966706 cites W2077552311 @default.
- W3155966706 cites W2079446507 @default.
- W3155966706 cites W2080426159 @default.
- W3155966706 cites W2091391741 @default.
- W3155966706 cites W2109543794 @default.
- W3155966706 cites W2116650656 @default.
- W3155966706 cites W2117217282 @default.
- W3155966706 cites W2119677671 @default.
- W3155966706 cites W2120143950 @default.
- W3155966706 cites W2121966499 @default.
- W3155966706 cites W2128537698 @default.
- W3155966706 cites W2135850991 @default.
- W3155966706 cites W2154990937 @default.
- W3155966706 cites W2165427528 @default.
- W3155966706 cites W2165914214 @default.
- W3155966706 cites W2166496519 @default.
- W3155966706 cites W2167115031 @default.
- W3155966706 cites W2168208715 @default.
- W3155966706 cites W2169152986 @default.
- W3155966706 cites W2181244039 @default.
- W3155966706 cites W2200046622 @default.
- W3155966706 cites W2280212630 @default.
- W3155966706 cites W2311380696 @default.
- W3155966706 cites W2321151839 @default.
- W3155966706 cites W2323582440 @default.
- W3155966706 cites W2504529755 @default.
- W3155966706 cites W2572344066 @default.
- W3155966706 cites W2602278861 @default.
- W3155966706 cites W2755721896 @default.
- W3155966706 cites W2764071986 @default.
- W3155966706 cites W2765661779 @default.
- W3155966706 cites W2766411031 @default.
- W3155966706 cites W2791325895 @default.
- W3155966706 cites W2791808315 @default.
- W3155966706 cites W2792978395 @default.
- W3155966706 cites W2793567331 @default.
- W3155966706 cites W280207433 @default.
- W3155966706 cites W2804845995 @default.
- W3155966706 cites W2807334958 @default.
- W3155966706 cites W2809177340 @default.
- W3155966706 cites W2887998229 @default.
- W3155966706 cites W2897337771 @default.
- W3155966706 cites W2904527017 @default.
- W3155966706 cites W2904528880 @default.
- W3155966706 cites W2911493122 @default.
- W3155966706 cites W2912937500 @default.
- W3155966706 cites W2923937720 @default.
- W3155966706 cites W2926182860 @default.
- W3155966706 cites W2944419623 @default.
- W3155966706 cites W2945279365 @default.
- W3155966706 cites W2951807991 @default.
- W3155966706 cites W2964584752 @default.
- W3155966706 cites W2965244259 @default.
- W3155966706 cites W2965717703 @default.
- W3155966706 cites W2969928181 @default.
- W3155966706 cites W2980734162 @default.
- W3155966706 cites W2998176350 @default.
- W3155966706 cites W3004196371 @default.
- W3155966706 cites W3004271841 @default.
- W3155966706 cites W3006422924 @default.
- W3155966706 cites W3012285865 @default.