Matches in SemOpenAlex for { <https://semopenalex.org/work/W3155969191> ?p ?o ?g. }
- W3155969191 endingPage "1282.e6" @default.
- W3155969191 startingPage "1268" @default.
- W3155969191 abstract "Cell fate commitment is controlled by cis-regulatory elements often located in remote regions of the genome. To examine the role of long-range DNA interactions in early development, we generated a high-resolution contact map of active enhancers in avian neural crest cells. This analysis uncovered a diverse repertoire of enhancers that are part of the gene regulatory network underlying specification. We found that neural crest identity is largely regulated by cis-regulatory elements that propagate signaling inputs to network components. These genomic sensors display a combination of optimal and suboptimal TCF/LEF-binding sites, which allow cells to respond to Wnt signaling in a position-dependent manner. We propose that, rather than acting as upstream activators, signaling systems feed into regulatory circuits in a hub-and-spoke architecture. These results shed light on the tridimensional organization of the neural crest genome and define how signaling systems provide progenitors with spatial cues that transform their molecular identity." @default.
- W3155969191 created "2021-04-26" @default.
- W3155969191 creator A5076154035 @default.
- W3155969191 creator A5082550238 @default.
- W3155969191 date "2021-05-01" @default.
- W3155969191 modified "2023-10-18" @default.
- W3155969191 title "The connectome of neural crest enhancers reveals regulatory features of signaling systems" @default.
- W3155969191 cites W1168105405 @default.
- W3155969191 cites W1559850800 @default.
- W3155969191 cites W1759652240 @default.
- W3155969191 cites W1900337607 @default.
- W3155969191 cites W1963807629 @default.
- W3155969191 cites W1971530006 @default.
- W3155969191 cites W1973062929 @default.
- W3155969191 cites W1976506302 @default.
- W3155969191 cites W1977308882 @default.
- W3155969191 cites W1978157283 @default.
- W3155969191 cites W1980036425 @default.
- W3155969191 cites W1982532675 @default.
- W3155969191 cites W2001857107 @default.
- W3155969191 cites W2002679487 @default.
- W3155969191 cites W2008458502 @default.
- W3155969191 cites W2011024729 @default.
- W3155969191 cites W2014677321 @default.
- W3155969191 cites W2019196925 @default.
- W3155969191 cites W2025034960 @default.
- W3155969191 cites W2042752490 @default.
- W3155969191 cites W2048350099 @default.
- W3155969191 cites W2064073950 @default.
- W3155969191 cites W2067585563 @default.
- W3155969191 cites W2071018297 @default.
- W3155969191 cites W2073891615 @default.
- W3155969191 cites W2077720819 @default.
- W3155969191 cites W2080870494 @default.
- W3155969191 cites W2084332810 @default.
- W3155969191 cites W2085089728 @default.
- W3155969191 cites W2098425296 @default.
- W3155969191 cites W2101704916 @default.
- W3155969191 cites W2102278945 @default.
- W3155969191 cites W2102619694 @default.
- W3155969191 cites W2102663142 @default.
- W3155969191 cites W2103597610 @default.
- W3155969191 cites W2114930475 @default.
- W3155969191 cites W2125397535 @default.
- W3155969191 cites W2134374915 @default.
- W3155969191 cites W2140034535 @default.
- W3155969191 cites W2140952049 @default.
- W3155969191 cites W2144096654 @default.
- W3155969191 cites W2152791321 @default.
- W3155969191 cites W2160697532 @default.
- W3155969191 cites W2170551349 @default.
- W3155969191 cites W2179438025 @default.
- W3155969191 cites W2185693210 @default.
- W3155969191 cites W2291751883 @default.
- W3155969191 cites W2308616703 @default.
- W3155969191 cites W2341539131 @default.
- W3155969191 cites W2481029670 @default.
- W3155969191 cites W2523285811 @default.
- W3155969191 cites W2562443513 @default.
- W3155969191 cites W2768739381 @default.
- W3155969191 cites W2789833802 @default.
- W3155969191 cites W2902081928 @default.
- W3155969191 cites W2949153281 @default.
- W3155969191 cites W2955718886 @default.
- W3155969191 cites W2968515123 @default.
- W3155969191 cites W2976392421 @default.
- W3155969191 cites W2981632514 @default.
- W3155969191 cites W2996705374 @default.
- W3155969191 cites W3014932320 @default.
- W3155969191 cites W3096345853 @default.
- W3155969191 cites W3124653941 @default.
- W3155969191 doi "https://doi.org/10.1016/j.devcel.2021.03.024" @default.
- W3155969191 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8445387" @default.
- W3155969191 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33852891" @default.
- W3155969191 hasPublicationYear "2021" @default.
- W3155969191 type Work @default.
- W3155969191 sameAs 3155969191 @default.
- W3155969191 citedByCount "13" @default.
- W3155969191 countsByYear W31559691912021 @default.
- W3155969191 countsByYear W31559691912022 @default.
- W3155969191 countsByYear W31559691912023 @default.
- W3155969191 crossrefType "journal-article" @default.
- W3155969191 hasAuthorship W3155969191A5076154035 @default.
- W3155969191 hasAuthorship W3155969191A5082550238 @default.
- W3155969191 hasBestOaLocation W31559691911 @default.
- W3155969191 hasConcept C104317684 @default.
- W3155969191 hasConcept C111936080 @default.
- W3155969191 hasConcept C126749454 @default.
- W3155969191 hasConcept C137620995 @default.
- W3155969191 hasConcept C150194340 @default.
- W3155969191 hasConcept C163952510 @default.
- W3155969191 hasConcept C165864922 @default.
- W3155969191 hasConcept C21592294 @default.
- W3155969191 hasConcept C2780071072 @default.
- W3155969191 hasConcept C54355233 @default.
- W3155969191 hasConcept C67339327 @default.
- W3155969191 hasConcept C70721500 @default.
- W3155969191 hasConcept C86339819 @default.