FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3155990523> ?p ?o ?g. }

• W3155990523 endingPage "3252" @default.
• W3155990523 startingPage "3237" @default.
• W3155990523 abstract "Key points Carotid body (CB) chemoreceptors are hyperactive in hypertension, and their acute activation produces bronchoconstriction. We show that the respiratory‐modulated bronchiolar tone, pulmonary parasympathetic efferent activity, and the firing frequency and synaptic excitation of bronchoconstrictor motoneurones in the nucleus ambiguus were all enhanced in spontaneous hypertensive (SH) rats. In SH rats, CB denervation reduced the respiratory‐related parasympathetic‐mediated bronchoconstrictor tone to levels seen in normotensive rats. Chemoreflex evoked bronchoconstrictor tone was heightened in SH versus normotensive rats. The intrinsic electrophysiological properties and morphology of bronchoconstrictor motoneurones were similar across rat strains. The heightened respiratory modulation of parasympathetic‐mediated bronchoconstrictor tone to the airways in SH rats is caused by afferent drive from the CBs. Abstract Much research has described heightened sympathetic activity in hypertension and diminished parasympathetic tone, especially to the heart. The carotid body (CB) chemoreceptors exhibit hyperreflexia and are hyperactive, providing excitatory drive to sympathetic networks in hypertension. Given that acute CB activation produces reflex evoked bronchoconstriction via activation of parasympathetic vagal efferents, we hypothesised that the parasympathetic bronchoconstrictor activity is enhanced in spontaneously hypertensive (SH) rats and that this is dependent on CB inputs. In situ preparations of Wistar and SH rats were used in which bronchiolar tone, the pulmonary branch of the vagus (pVN) and phrenic nerves were recorded simultaneously; whole cell patch clamp recordings of bronchoconstrictor vagal motoneurones were also made from the nucleus ambiguus. Bronchiolar tone, pVN and bronchoconstrictor motoneurones were respiratory modulated and this modulation was enhanced in SH rats. These differences were all eliminated after CB denervation. Stimulation of the CBs increased the phrenic frequency that caused a summation of the respiratory‐related increases in pVN, resulting in the development of bronchoconstrictor tone. This tone was exaggerated in SH rats. The enhanced respiratory‐parasympathetic coupling to airways in SH rats was not due to differences in the intrinsic electrophysiological properties of bronchoconstrictor motoneurones but reflected heightened pre‐inspiratory‐ and inspiratory‐related synaptic drive. In summary, in SH rats the phasic respiratory modulation of parasympathetic tone to the airways is elevated and the greater development of this bronchoconstrictor tone is caused by the heightened afferent drive originating from the CBs. Thus, targeting the CBs may prove effective for increasing lower airway patency." @default.
• W3155990523 created "2021-04-26" @default.
• W3155990523 creator A5004974976 @default.
• W3155990523 creator A5014346267 @default.
• W3155990523 creator A5029708027 @default.
• W3155990523 creator A5071472581 @default.
• W3155990523 creator A5082999892 @default.
• W3155990523 date "2021-05-12" @default.
• W3155990523 modified "2023-09-27" @default.
• W3155990523 title "Heightened respiratory‐parasympathetic coupling to airways in the spontaneously hypertensive rat" @default.
• W3155990523 cites W1580490094 @default.
• W3155990523 cites W1858094378 @default.
• W3155990523 cites W1968801061 @default.
• W3155990523 cites W1977003032 @default.
• W3155990523 cites W1977962340 @default.
• W3155990523 cites W1980107063 @default.
• W3155990523 cites W1986430429 @default.
• W3155990523 cites W1992483844 @default.
• W3155990523 cites W1993428601 @default.
• W3155990523 cites W1994198250 @default.
• W3155990523 cites W1997309138 @default.
• W3155990523 cites W1999340472 @default.
• W3155990523 cites W2012042106 @default.
• W3155990523 cites W2025872245 @default.
• W3155990523 cites W2044520352 @default.
• W3155990523 cites W2045638363 @default.
• W3155990523 cites W2046818294 @default.
• W3155990523 cites W2060071571 @default.
• W3155990523 cites W2068474073 @default.
• W3155990523 cites W2072647461 @default.
• W3155990523 cites W2084224095 @default.
• W3155990523 cites W2095518697 @default.
• W3155990523 cites W2101369865 @default.
• W3155990523 cites W2104402415 @default.
• W3155990523 cites W2113568840 @default.
• W3155990523 cites W2117671437 @default.
• W3155990523 cites W2120491333 @default.
• W3155990523 cites W2120709057 @default.
• W3155990523 cites W2128107556 @default.
• W3155990523 cites W2131896912 @default.
• W3155990523 cites W2142940235 @default.
• W3155990523 cites W2145912168 @default.
• W3155990523 cites W2171131306 @default.
• W3155990523 cites W2175854707 @default.
• W3155990523 cites W2223483986 @default.
• W3155990523 cites W2229896090 @default.
• W3155990523 cites W2281642326 @default.
• W3155990523 cites W2287935024 @default.
• W3155990523 cites W2345153016 @default.
• W3155990523 cites W2406666636 @default.
• W3155990523 cites W2516502922 @default.
• W3155990523 cites W2521545344 @default.
• W3155990523 cites W2587962034 @default.
• W3155990523 cites W2792288556 @default.
• W3155990523 cites W2810075231 @default.
• W3155990523 cites W2892845010 @default.
• W3155990523 cites W2948411021 @default.
• W3155990523 cites W2968768595 @default.
• W3155990523 cites W2984298208 @default.
• W3155990523 cites W3034185915 @default.
• W3155990523 doi "https://doi.org/10.1113/jp280981" @default.
• W3155990523 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33873234" @default.
• W3155990523 hasPublicationYear "2021" @default.
• W3155990523 type Work @default.
• W3155990523 sameAs 3155990523 @default.
• W3155990523 citedByCount "2" @default.
• W3155990523 countsByYear W31559905232022 @default.
• W3155990523 crossrefType "journal-article" @default.
• W3155990523 hasAuthorship W3155990523A5004974976 @default.
• W3155990523 hasAuthorship W3155990523A5014346267 @default.
• W3155990523 hasAuthorship W3155990523A5029708027 @default.
• W3155990523 hasAuthorship W3155990523A5071472581 @default.
• W3155990523 hasAuthorship W3155990523A5082999892 @default.
• W3155990523 hasBestOaLocation W31559905231 @default.
• W3155990523 hasConcept C10928738 @default.
• W3155990523 hasConcept C126322002 @default.
• W3155990523 hasConcept C134018914 @default.
• W3155990523 hasConcept C185592680 @default.
• W3155990523 hasConcept C191237925 @default.
• W3155990523 hasConcept C24998067 @default.
• W3155990523 hasConcept C2776042228 @default.
• W3155990523 hasConcept C2776512019 @default.
• W3155990523 hasConcept C2777372248 @default.
• W3155990523 hasConcept C2777953023 @default.
• W3155990523 hasConcept C2778110749 @default.
• W3155990523 hasConcept C2779263132 @default.
• W3155990523 hasConcept C2780761756 @default.
• W3155990523 hasConcept C2780769369 @default.
• W3155990523 hasConcept C2780866171 @default.
• W3155990523 hasConcept C2781404750 @default.
• W3155990523 hasConcept C42219234 @default.
• W3155990523 hasConcept C529278444 @default.
• W3155990523 hasConcept C534529494 @default.
• W3155990523 hasConcept C71924100 @default.
• W3155990523 hasConcept C83974742 @default.
• W3155990523 hasConcept C84393581 @default.
• W3155990523 hasConceptScore W3155990523C10928738 @default.
• W3155990523 hasConceptScore W3155990523C126322002 @default.

• next