FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3156011617> ?p ?o ?g. }

• W3156011617 abstract "Nonalcoholic fatty liver disease (NAFLD) is a common metabolic disease that affects 20-30% of individuals worldwide. Liver puncture remains the gold standard for the diagnosis of liver diseases despite limitations regarding invasive nature and sample variability. It is of great clinical significance to find noninvasive biomarkers to detect and predict NAFLD.The aims of this study were to identify potential serum markers in individuals with early-stage NAFLD and to advance the mechanistic understanding of this disease using a high-throughput mass spectrometry-based untargeted metabolomics approach.One hundred and twelve patients with early-stage NAFLD aged 18-55 were recruited according to the guidelines. The control group included 112 healthy participants. The demographic, anthropometric, clinical and laboratory data of all participants were systematically collected. Serum samples were obtained after an overnight fast. The comprehensive serum metabolomic analysis was performed by ultra-performance liquid chromatography-Orbitrap mass spectrometry. The resultant data was processed by Compound Discover and SIMCA-P software to validate the potential biomarkers. Significantly altered metabolites were evaluated by variable importance in projection value (VIP > 1) and ANOVA (p < 0.01). Pathway analysis was performed using MetaboAnalyst 4.0.The liver function test of early NAFLD patients showed no statistical differences to control group (p > 0.05). However, obvious differences in blood lipids were observed between subjects with NAFLD and controls (p < 0.001). In total, 55 metabolites showed significant changes in experimental group were identified. The area under curve (AUC) values deduced by receiver operating curve (ROC) analysis indicated that these newly identified biomarkers have high predictability and reliability. Of these, 15 metabolites with AUC greater than 0.9 were of great diagnostic value in early NAFLD patients.In this study, a total of 15 serum metabolites were found to strongly associate with early NAFLD. These biomarkers may have great clinical significance in the early diagnosis of NAFLD, as well as to follow response to therapeutic interventions." @default.
• W3156011617 created "2021-04-26" @default.
• W3156011617 creator A5001547762 @default.
• W3156011617 creator A5008844169 @default.
• W3156011617 creator A5028217351 @default.
• W3156011617 creator A5039172691 @default.
• W3156011617 creator A5043049997 @default.
• W3156011617 creator A5045180552 @default.
• W3156011617 creator A5074146212 @default.
• W3156011617 creator A5079628969 @default.
• W3156011617 creator A5088333922 @default.
• W3156011617 creator A5089008549 @default.
• W3156011617 date "2021-04-15" @default.
• W3156011617 modified "2023-10-15" @default.
• W3156011617 title "Metabolic analysis of early nonalcoholic fatty liver disease in humans using liquid chromatography-mass spectrometry" @default.
• W3156011617 cites W1258381707 @default.
• W3156011617 cites W1484320536 @default.
• W3156011617 cites W1622799587 @default.
• W3156011617 cites W1975567145 @default.
• W3156011617 cites W1979002038 @default.
• W3156011617 cites W1982185707 @default.
• W3156011617 cites W1982490692 @default.
• W3156011617 cites W1989326472 @default.
• W3156011617 cites W1994797654 @default.
• W3156011617 cites W2000545769 @default.
• W3156011617 cites W2002349285 @default.
• W3156011617 cites W2033467594 @default.
• W3156011617 cites W2034527070 @default.
• W3156011617 cites W2037977025 @default.
• W3156011617 cites W2068509302 @default.
• W3156011617 cites W2070427334 @default.
• W3156011617 cites W2074203821 @default.
• W3156011617 cites W2083989578 @default.
• W3156011617 cites W2110217973 @default.
• W3156011617 cites W2122623396 @default.
• W3156011617 cites W2123055140 @default.
• W3156011617 cites W2148574834 @default.
• W3156011617 cites W2160297030 @default.
• W3156011617 cites W2163484250 @default.
• W3156011617 cites W2167439606 @default.
• W3156011617 cites W2237640945 @default.
• W3156011617 cites W2273038955 @default.
• W3156011617 cites W2567521812 @default.
• W3156011617 cites W2580702439 @default.
• W3156011617 cites W2585915213 @default.
• W3156011617 cites W2616834435 @default.
• W3156011617 cites W2657296316 @default.
• W3156011617 cites W2734574592 @default.
• W3156011617 cites W2794615693 @default.
• W3156011617 cites W2795554754 @default.
• W3156011617 cites W2799617448 @default.
• W3156011617 cites W2805142669 @default.
• W3156011617 cites W2808290665 @default.
• W3156011617 cites W2883728156 @default.
• W3156011617 cites W2888285558 @default.
• W3156011617 cites W2894655218 @default.
• W3156011617 cites W2908036779 @default.
• W3156011617 cites W2912303392 @default.
• W3156011617 cites W2919481049 @default.
• W3156011617 cites W3003865038 @default.
• W3156011617 cites W3015964165 @default.
• W3156011617 doi "https://doi.org/10.1186/s12967-021-02820-7" @default.
• W3156011617 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8050915" @default.
• W3156011617 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33858428" @default.
• W3156011617 hasPublicationYear "2021" @default.
• W3156011617 type Work @default.
• W3156011617 sameAs 3156011617 @default.
• W3156011617 citedByCount "18" @default.
• W3156011617 countsByYear W31560116172021 @default.
• W3156011617 countsByYear W31560116172022 @default.
• W3156011617 countsByYear W31560116172023 @default.
• W3156011617 crossrefType "journal-article" @default.
• W3156011617 hasAuthorship W3156011617A5001547762 @default.
• W3156011617 hasAuthorship W3156011617A5008844169 @default.
• W3156011617 hasAuthorship W3156011617A5028217351 @default.
• W3156011617 hasAuthorship W3156011617A5039172691 @default.
• W3156011617 hasAuthorship W3156011617A5043049997 @default.
• W3156011617 hasAuthorship W3156011617A5045180552 @default.
• W3156011617 hasAuthorship W3156011617A5074146212 @default.
• W3156011617 hasAuthorship W3156011617A5079628969 @default.
• W3156011617 hasAuthorship W3156011617A5088333922 @default.
• W3156011617 hasAuthorship W3156011617A5089008549 @default.
• W3156011617 hasBestOaLocation W31560116171 @default.
• W3156011617 hasConcept C126322002 @default.
• W3156011617 hasConcept C21565614 @default.
• W3156011617 hasConcept C2776954865 @default.
• W3156011617 hasConcept C2777075537 @default.
• W3156011617 hasConcept C2778772119 @default.
• W3156011617 hasConcept C2779134260 @default.
• W3156011617 hasConcept C2780221984 @default.
• W3156011617 hasConcept C42407357 @default.
• W3156011617 hasConcept C58471807 @default.
• W3156011617 hasConcept C60644358 @default.
• W3156011617 hasConcept C63363279 @default.
• W3156011617 hasConcept C71924100 @default.
• W3156011617 hasConcept C76318530 @default.
• W3156011617 hasConcept C86803240 @default.
• W3156011617 hasConcept C90924648 @default.
• W3156011617 hasConcept C99476002 @default.
• W3156011617 hasConceptScore W3156011617C126322002 @default.

• next