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- W3156110951 abstract "Abstract Background Little is known about DNMT3A expression and its prognostic significance in childhood B cell precursor acute lymphoblastic leukemia (BCP-ALL). Methods We determined DNMT3A mRNA expression in 102 children with BCP-ALL. Correlations with relapse-free survival (RFS) and common clinical characteristics were analyzed. DNMT3A was stably knocked out by CRISPR/Cas9 gene editing technology in 697 cell line. Cell proliferation activity after treated with daunorubicin was determined by CCK8 assay in DNMT3A KO 697 cell line. Results DNMT3A expression in BCP-ALL patients who were in CCR was higher than in those who got relapse ( P =0.0111). Receiver operating characteristic curve showed prognostic significance of DNMT3A expression ( P =0.003). Low expression of DNMT3A (<0.197) was significantly correlated with poor RFS ( P <0.001) in children with BCP-ALL. Knock-out of DNMT3A in 697 cell line significantly increased IC50 of daunorubicin ( P =0.0057), indicating elevated resistance to daunorubicin. Conclusions Low expression of DNMT3A associates with poor prognosis in children with BCP-ALL. Knock-out of DNMT3A confers resistance to daunorubicin on leukemic cells." @default.
- W3156110951 created "2021-04-26" @default.
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- W3156110951 date "2021-04-12" @default.
- W3156110951 modified "2023-10-18" @default.
- W3156110951 title "DNMT3A Low-Expression is Correlated to Poor Prognosis in Childhood B Cell Precursor Acute Lymphoblastic Leukemia and Confers Resistance to Daunorubicin on Leukemic Cells" @default.
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- W3156110951 doi "https://doi.org/10.21203/rs.3.rs-193259/v1" @default.
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