FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3156121708> ?p ?o ?g. }

• W3156121708 endingPage "18524" @default.
• W3156121708 startingPage "18511" @default.
• W3156121708 abstract "Polymer capsules fabricated via the layer-by-layer (LbL) approach have emerged as promising biomedical systems for the release of a wide variety of therapeutic agents, owing to their tunable and controllable structure and the possibility to include several functionalities in the polymeric membrane during the fabrication process. However, the limitation of the capsules with a single functionality to overcome the challenges involved in the treatment of complex pathologies denotes the need to develop multifunctional capsules capable of targeting several mediators and/or mechanisms. Oxidative stress is caused by the accumulation of reactive oxygen species [e.g., hydrogen peroxide (H2O2), hydroxyl radicals (•OH), and superoxide anion radicals (•O2–)] in the cellular microenvironment and is a key modulator in the pathology of a broad range of inflammatory diseases. The disease microenvironment is also characterized by the presence of proinflammatory cytokines, increased levels of matrix metalloproteinases, and acidic pH, all of which could be exploited to trigger the release of therapeutic agents. In the present work, multifunctional capsules were fabricated via the LbL approach. Capsules were loaded with an antioxidant enzyme (catalase) and functionalized with a model drug (doxorubicin), which was conjugated to an amine-containing dendritic polyglycerol through a pH-responsive linker. These capsules efficiently scavenge H2O2 from solution, protecting cells from oxidative stress, and release the model drug in acidic microenvironments. Accordingly, in this work, a polymeric microplatform is presented as an unexplored combinatorial approach applicable for multiple targets of inflammatory diseases, in order to perform controlled spatiotemporal enzymatic reactions and drug release in response to biologically relevant stimuli." @default.
• W3156121708 created "2021-04-26" @default.
• W3156121708 creator A5057886684 @default.
• W3156121708 creator A5058217051 @default.
• W3156121708 creator A5066172157 @default.
• W3156121708 creator A5068613170 @default.
• W3156121708 creator A5079744913 @default.
• W3156121708 date "2021-04-16" @default.
• W3156121708 modified "2023-10-18" @default.
• W3156121708 title "Smart Layer-by-Layer Polymeric Microreactors: pH-Triggered Drug Release and Attenuation of Cellular Oxidative Stress as Prospective Combination Therapy" @default.
• W3156121708 cites W1828973643 @default.
• W3156121708 cites W1838083570 @default.
• W3156121708 cites W1964746125 @default.
• W3156121708 cites W1973252400 @default.
• W3156121708 cites W1973378461 @default.
• W3156121708 cites W1975139160 @default.
• W3156121708 cites W1983786752 @default.
• W3156121708 cites W1990633787 @default.
• W3156121708 cites W1995305066 @default.
• W3156121708 cites W1996206103 @default.
• W3156121708 cites W2002341807 @default.
• W3156121708 cites W2006595429 @default.
• W3156121708 cites W2009564165 @default.
• W3156121708 cites W2027876233 @default.
• W3156121708 cites W2029851331 @default.
• W3156121708 cites W2036178455 @default.
• W3156121708 cites W2036527751 @default.
• W3156121708 cites W2036993803 @default.
• W3156121708 cites W2037751288 @default.
• W3156121708 cites W2043120353 @default.
• W3156121708 cites W2046411314 @default.
• W3156121708 cites W2050082814 @default.
• W3156121708 cites W2051193226 @default.
• W3156121708 cites W2055713782 @default.
• W3156121708 cites W2059298390 @default.
• W3156121708 cites W2060290086 @default.
• W3156121708 cites W2060451360 @default.
• W3156121708 cites W2061139525 @default.
• W3156121708 cites W2063269879 @default.
• W3156121708 cites W2067779785 @default.
• W3156121708 cites W2073953148 @default.
• W3156121708 cites W2076977603 @default.
• W3156121708 cites W2081704662 @default.
• W3156121708 cites W2086092238 @default.
• W3156121708 cites W2089951589 @default.
• W3156121708 cites W2089996151 @default.
• W3156121708 cites W2090966230 @default.
• W3156121708 cites W2096935480 @default.
• W3156121708 cites W2109387694 @default.
• W3156121708 cites W2109975771 @default.
• W3156121708 cites W2117269962 @default.
• W3156121708 cites W2126740625 @default.
• W3156121708 cites W2128321159 @default.
• W3156121708 cites W2137677244 @default.
• W3156121708 cites W2143984611 @default.
• W3156121708 cites W2151860745 @default.
• W3156121708 cites W2163187840 @default.
• W3156121708 cites W2209910213 @default.
• W3156121708 cites W2282436316 @default.
• W3156121708 cites W2296793508 @default.
• W3156121708 cites W2301038109 @default.
• W3156121708 cites W2306174533 @default.
• W3156121708 cites W2312392534 @default.
• W3156121708 cites W2316363969 @default.
• W3156121708 cites W2316865493 @default.
• W3156121708 cites W2323007809 @default.
• W3156121708 cites W2342568663 @default.
• W3156121708 cites W2405921850 @default.
• W3156121708 cites W2410544579 @default.
• W3156121708 cites W2468724781 @default.
• W3156121708 cites W2485160639 @default.
• W3156121708 cites W2511628046 @default.
• W3156121708 cites W2542283444 @default.
• W3156121708 cites W2547553185 @default.
• W3156121708 cites W2568510753 @default.
• W3156121708 cites W2586407391 @default.
• W3156121708 cites W2593566190 @default.
• W3156121708 cites W2598168740 @default.
• W3156121708 cites W2740417415 @default.
• W3156121708 cites W2749132894 @default.
• W3156121708 cites W2756396967 @default.
• W3156121708 cites W2771263162 @default.
• W3156121708 cites W2774632999 @default.
• W3156121708 cites W2793980916 @default.
• W3156121708 cites W2795432914 @default.
• W3156121708 cites W2796499245 @default.
• W3156121708 cites W2799330168 @default.
• W3156121708 cites W2803503958 @default.
• W3156121708 cites W2804874041 @default.
• W3156121708 cites W2810789548 @default.
• W3156121708 cites W2891335868 @default.
• W3156121708 cites W2903625960 @default.
• W3156121708 cites W2921237536 @default.
• W3156121708 cites W2935524958 @default.
• W3156121708 cites W2942515504 @default.
• W3156121708 cites W2949664458 @default.
• W3156121708 cites W2952855377 @default.
• W3156121708 cites W2954569873 @default.

• next