Matches in SemOpenAlex for { <https://semopenalex.org/work/W3156145557> ?p ?o ?g. }
- W3156145557 abstract "Reactive oxygen species (ROS) are generated and consumed in living organism for normal metabolism. Paradoxically, the overproduction and/or mismanagement of ROS have been involved in pathogenesis and progression of various human diseases. Here, we reported a two-dimensional (2D) vanadium carbide (V2C) MXene nanoenzyme (MXenzyme) that can mimic up to six naturally-occurring enzymes, including superoxide dismutase (SOD), catalase (CAT), peroxidase (POD), glutathione peroxidase (GPx), thiol peroxidase (TPx) and haloperoxidase (HPO). Based on these enzyme-mimicking properties, the constructed 2D V2C MXenzyme not only possesses high biocompatibility but also exhibits robust in vitro cytoprotection against oxidative stress. Importantly, 2D V2C MXenzyme rebuilds the redox homeostasis without perturbing the endogenous antioxidant status and relieves ROS-induced damage with benign in vivo therapeutic effects, as demonstrated in both inflammation and neurodegeneration animal models. These findings open an avenue to enable the use of MXenzyme as a remedial nanoplatform to treat ROS-mediated inflammatory and neurodegenerative diseases." @default.
- W3156145557 created "2021-04-26" @default.
- W3156145557 creator A5007239313 @default.
- W3156145557 creator A5010396280 @default.
- W3156145557 creator A5050991862 @default.
- W3156145557 creator A5059839384 @default.
- W3156145557 creator A5065101788 @default.
- W3156145557 creator A5072282231 @default.
- W3156145557 creator A5075247746 @default.
- W3156145557 creator A5077169247 @default.
- W3156145557 date "2021-04-13" @default.
- W3156145557 modified "2023-10-16" @default.
- W3156145557 title "2D vanadium carbide MXenzyme to alleviate ROS-mediated inflammatory and neurodegenerative diseases" @default.
- W3156145557 cites W1875851620 @default.
- W3156145557 cites W1969963326 @default.
- W3156145557 cites W1987320336 @default.
- W3156145557 cites W1989987141 @default.
- W3156145557 cites W1990640161 @default.
- W3156145557 cites W1991952977 @default.
- W3156145557 cites W1992304465 @default.
- W3156145557 cites W1993250284 @default.
- W3156145557 cites W2000631088 @default.
- W3156145557 cites W2014251702 @default.
- W3156145557 cites W2024147943 @default.
- W3156145557 cites W2031028771 @default.
- W3156145557 cites W2044494908 @default.
- W3156145557 cites W2068759297 @default.
- W3156145557 cites W2073292682 @default.
- W3156145557 cites W2086561195 @default.
- W3156145557 cites W2109977819 @default.
- W3156145557 cites W2126699352 @default.
- W3156145557 cites W2166209263 @default.
- W3156145557 cites W2170913114 @default.
- W3156145557 cites W2171984357 @default.
- W3156145557 cites W2228424836 @default.
- W3156145557 cites W2296523452 @default.
- W3156145557 cites W2339575065 @default.
- W3156145557 cites W2529562623 @default.
- W3156145557 cites W2550440327 @default.
- W3156145557 cites W2606757801 @default.
- W3156145557 cites W2689318812 @default.
- W3156145557 cites W273079295 @default.
- W3156145557 cites W2747423355 @default.
- W3156145557 cites W2756282825 @default.
- W3156145557 cites W2766661870 @default.
- W3156145557 cites W2771918010 @default.
- W3156145557 cites W2782051023 @default.
- W3156145557 cites W2782802275 @default.
- W3156145557 cites W2791613310 @default.
- W3156145557 cites W2791731272 @default.
- W3156145557 cites W2791764370 @default.
- W3156145557 cites W2794719705 @default.
- W3156145557 cites W2794877002 @default.
- W3156145557 cites W2805911412 @default.
- W3156145557 cites W2807191970 @default.
- W3156145557 cites W2810503096 @default.
- W3156145557 cites W2867588383 @default.
- W3156145557 cites W2883440571 @default.
- W3156145557 cites W2905296697 @default.
- W3156145557 cites W2914693810 @default.
- W3156145557 cites W2942649738 @default.
- W3156145557 cites W2947512353 @default.
- W3156145557 cites W2948592804 @default.
- W3156145557 cites W2949586599 @default.
- W3156145557 cites W2954950405 @default.
- W3156145557 cites W2961863584 @default.
- W3156145557 cites W2971095732 @default.
- W3156145557 cites W2980167402 @default.
- W3156145557 cites W2986448243 @default.
- W3156145557 cites W3005173588 @default.
- W3156145557 doi "https://doi.org/10.1038/s41467-021-22278-x" @default.
- W3156145557 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8044242" @default.
- W3156145557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33850133" @default.
- W3156145557 hasPublicationYear "2021" @default.
- W3156145557 type Work @default.
- W3156145557 sameAs 3156145557 @default.
- W3156145557 citedByCount "159" @default.
- W3156145557 countsByYear W31561455572021 @default.
- W3156145557 countsByYear W31561455572022 @default.
- W3156145557 countsByYear W31561455572023 @default.
- W3156145557 crossrefType "journal-article" @default.
- W3156145557 hasAuthorship W3156145557A5007239313 @default.
- W3156145557 hasAuthorship W3156145557A5010396280 @default.
- W3156145557 hasAuthorship W3156145557A5050991862 @default.
- W3156145557 hasAuthorship W3156145557A5059839384 @default.
- W3156145557 hasAuthorship W3156145557A5065101788 @default.
- W3156145557 hasAuthorship W3156145557A5072282231 @default.
- W3156145557 hasAuthorship W3156145557A5075247746 @default.
- W3156145557 hasAuthorship W3156145557A5077169247 @default.
- W3156145557 hasBestOaLocation W31561455571 @default.
- W3156145557 hasConcept C142724271 @default.
- W3156145557 hasConcept C162008176 @default.
- W3156145557 hasConcept C181199279 @default.
- W3156145557 hasConcept C185592680 @default.
- W3156145557 hasConcept C2775838275 @default.
- W3156145557 hasConcept C2776151105 @default.
- W3156145557 hasConcept C2776925932 @default.
- W3156145557 hasConcept C2778004101 @default.
- W3156145557 hasConcept C2778760513 @default.
- W3156145557 hasConcept C2778979269 @default.