FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3156157805> ?p ?o ?g. }

• W3156157805 endingPage "2026" @default.
• W3156157805 startingPage "2017" @default.
• W3156157805 abstract "Abstract There is increasing evidence that platelets participate in multiple pathophysiological processes other than thrombosis and hemostasis, such as immunity, inflammation, embryonic development, and cancer progression. A recent study revealed that heme (hemin)-activated platelets induce macrophage extracellular traps (METs) and exacerbate rhabdomyolysis-induced acute kidney injury (RAKI); however, how hemin activates platelets remains unclear. Here, we report that both C-type lectin-like receptor-2 (CLEC-2) and glycoprotein VI (GPVI) are platelet hemin receptors and are involved in the exacerbation of RAKI. We investigated hemin-induced platelet aggregation in humans and mice, binding of hemin to CLEC-2 and GPVI, the RAKI-associated phenotype in a mouse model, and in vitro MET formation. Using western blotting and surface plasmon resonance, we showed that hemin activates human platelets by stimulating the phosphorylation of SYK and PLCγ2 and directly binding to both CLEC-2 and GPVI. Furthermore, hemin-induced murine platelet aggregation was partially reduced in CLEC-2–depleted and FcRγ-deficient (equivalent to GPVI-deficient) platelets and almost completely inhibited in CLEC-2–depleted FcRγ-deficient (double-knockout) platelets. In addition, hemin-induced murine platelet aggregation was inhibited by the CLEC-2 inhibitor cobalt hematoporphyrin or GPVI antibody (JAQ-1). Renal dysfunction, tubular injury, and MET formation were attenuated in double-knockout RAKI mice. Furthermore, in vitro MET formation assay showed that the downstream signaling pathway of CLEC-2 and GPVI is involved in MET formation. We propose that both CLEC-2 and GPVI in platelets play an important role in RAKI development." @default.
• W3156157805 created "2021-04-26" @default.
• W3156157805 creator A5001709112 @default.
• W3156157805 creator A5008738858 @default.
• W3156157805 creator A5027219029 @default.
• W3156157805 creator A5027591869 @default.
• W3156157805 creator A5033293938 @default.
• W3156157805 creator A5036024452 @default.
• W3156157805 creator A5041624621 @default.
• W3156157805 creator A5046601164 @default.
• W3156157805 creator A5069721725 @default.
• W3156157805 creator A5075359860 @default.
• W3156157805 creator A5081460244 @default.
• W3156157805 creator A5087902228 @default.
• W3156157805 date "2021-04-12" @default.
• W3156157805 modified "2023-10-16" @default.
• W3156157805 title "Heme activates platelets and exacerbates rhabdomyolysis-induced acute kidney injury via CLEC-2 and GPVI/FcRγ" @default.
• W3156157805 cites W1964216939 @default.
• W3156157805 cites W1990200619 @default.
• W3156157805 cites W1993318706 @default.
• W3156157805 cites W2022316473 @default.
• W3156157805 cites W2041326156 @default.
• W3156157805 cites W2075730871 @default.
• W3156157805 cites W2094190961 @default.
• W3156157805 cites W2102556842 @default.
• W3156157805 cites W2119563305 @default.
• W3156157805 cites W2121894911 @default.
• W3156157805 cites W2130083671 @default.
• W3156157805 cites W2143455036 @default.
• W3156157805 cites W2148969684 @default.
• W3156157805 cites W2152621712 @default.
• W3156157805 cites W2153120549 @default.
• W3156157805 cites W2194206932 @default.
• W3156157805 cites W2346770762 @default.
• W3156157805 cites W2561202332 @default.
• W3156157805 cites W2582239943 @default.
• W3156157805 cites W2619739951 @default.
• W3156157805 cites W2761080716 @default.
• W3156157805 cites W2783276285 @default.
• W3156157805 cites W2790923733 @default.
• W3156157805 cites W2891208523 @default.
• W3156157805 cites W2907399917 @default.
• W3156157805 cites W2971693886 @default.
• W3156157805 cites W2990152294 @default.
• W3156157805 doi "https://doi.org/10.1182/bloodadvances.2020001698" @default.
• W3156157805 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8045506" @default.
• W3156157805 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33843987" @default.
• W3156157805 hasPublicationYear "2021" @default.
• W3156157805 type Work @default.
• W3156157805 sameAs 3156157805 @default.
• W3156157805 citedByCount "20" @default.
• W3156157805 countsByYear W31561578052021 @default.
• W3156157805 countsByYear W31561578052022 @default.
• W3156157805 countsByYear W31561578052023 @default.
• W3156157805 crossrefType "journal-article" @default.
• W3156157805 hasAuthorship W3156157805A5001709112 @default.
• W3156157805 hasAuthorship W3156157805A5008738858 @default.
• W3156157805 hasAuthorship W3156157805A5027219029 @default.
• W3156157805 hasAuthorship W3156157805A5027591869 @default.
• W3156157805 hasAuthorship W3156157805A5033293938 @default.
• W3156157805 hasAuthorship W3156157805A5036024452 @default.
• W3156157805 hasAuthorship W3156157805A5041624621 @default.
• W3156157805 hasAuthorship W3156157805A5046601164 @default.
• W3156157805 hasAuthorship W3156157805A5069721725 @default.
• W3156157805 hasAuthorship W3156157805A5075359860 @default.
• W3156157805 hasAuthorship W3156157805A5081460244 @default.
• W3156157805 hasAuthorship W3156157805A5087902228 @default.
• W3156157805 hasBestOaLocation W31561578051 @default.
• W3156157805 hasConcept C126322002 @default.
• W3156157805 hasConcept C181199279 @default.
• W3156157805 hasConcept C185592680 @default.
• W3156157805 hasConcept C2776217839 @default.
• W3156157805 hasConcept C2777723881 @default.
• W3156157805 hasConcept C2778589496 @default.
• W3156157805 hasConcept C2780573682 @default.
• W3156157805 hasConcept C3018697912 @default.
• W3156157805 hasConcept C55493867 @default.
• W3156157805 hasConcept C71924100 @default.
• W3156157805 hasConcept C89560881 @default.
• W3156157805 hasConceptScore W3156157805C126322002 @default.
• W3156157805 hasConceptScore W3156157805C181199279 @default.
• W3156157805 hasConceptScore W3156157805C185592680 @default.
• W3156157805 hasConceptScore W3156157805C2776217839 @default.
• W3156157805 hasConceptScore W3156157805C2777723881 @default.
• W3156157805 hasConceptScore W3156157805C2778589496 @default.
• W3156157805 hasConceptScore W3156157805C2780573682 @default.
• W3156157805 hasConceptScore W3156157805C3018697912 @default.
• W3156157805 hasConceptScore W3156157805C55493867 @default.
• W3156157805 hasConceptScore W3156157805C71924100 @default.
• W3156157805 hasConceptScore W3156157805C89560881 @default.
• W3156157805 hasIssue "7" @default.
• W3156157805 hasLocation W31561578051 @default.
• W3156157805 hasLocation W31561578052 @default.
• W3156157805 hasOpenAccess W3156157805 @default.
• W3156157805 hasPrimaryLocation W31561578051 @default.
• W3156157805 hasRelatedWork W2028497575 @default.
• W3156157805 hasRelatedWork W2080086114 @default.
• W3156157805 hasRelatedWork W2123558747 @default.

• next