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- W3156162523 abstract "Current therapeutic options for atopic dermatitis (AD) consist of either broad or targeted immunosuppressive agents. However, the natural course of AD can hardly be modified, as the disease invariably returns after cessation of treatment. Tissue-resident memory T-cells are hypothesized to be relevant players in mediating disease-specific ‘immune memory’, but their exact immunopathological phenotype is so far unknown. By using a multi-omics approach involving single-cell RNA sequencing combined with multiplex proteomics of skin samples, we studied AD patients undergoing short (16 weeks) and long-term (one year) treatment with the IL-4Rα blocker dupilumab. IL-4Rα blockade resulted in clearance of disease, decrease in skin immune cell counts, and normalization of transcriptomic dysregulation of keratinocytes. Interestingly, we found distinct populations of dendritic cells (DC) and memory T-cells that were largely absent in healthy control skin to persist in AD up to one year of treatment. These included LAMP3+ CCL22+ mature DC, CRTH2+ CD161+ Th2A cells, and CRTAM+ cytotoxic T-cells, expressing peak levels of CCL17 (DC) and IL13 (T-cells). Th2A cells showed a specific receptor constellation of IL17RB, IL1RL1 (ST2) and CRLF2, possibly rendering them key responders to the AD-typical epidermal alarmins IL25, IL33 and TSLP. We thus identified persisting mature DC and T-cells that maintained an inflammatory phenotype up to one year of treatment,equipped with all receptors to facilitate a keratinocyte-DC-Th2-mediated inflammatory response. These cell populations emerge as central players of a skin-intrinsic disease memory that leads to disease recurrences, and might therefore be promising targets to achieve a more sustained therapeutic response." @default.
- W3156162523 created "2021-04-26" @default.
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- W3156162523 date "2021-05-01" @default.
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- W3156162523 title "659 Persistence of mature dendritic cells, Th2A and Tc2 cells characterize clinically resolved atopic dermatitis under IL-4R-alpha blockade" @default.
- W3156162523 doi "https://doi.org/10.1016/j.jid.2021.02.689" @default.
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