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- W3156202211 abstract "Abstract Proteome profile changes in Alzheimer's disease (AD) brains have been reported. However, it is unclear whether they represent a continuous process, or whether there is a sequential involvement of distinct proteins. To address this question, we used mass spectrometry. We analyzed soluble, dispersible, sodium dodecyl sulfate, and formic acid fractions of neocortex homogenates (mainly Brodmann area 17‐19) from 18 pathologically diagnosed preclinical AD, 17 symptomatic AD, and 18 cases without signs of neurodegeneration. By doing so, we identified four groups of AD‐related proteins being changed in levels in preclinical and symptomatic AD cases: early‐responding, late‐responding, gradually‐changing, and fraction‐shifting proteins. Gene ontology analysis of these proteins and all known AD‐risk/causative genes identified vesicle endocytosis and the secretory pathway‐related processes as an early‐involved AD component. In conclusion, our findings suggest that subtle changes involving the secretory pathway and endocytosis precede severe proteome changes in symptomatic AD as part of the preclinical phase of AD. The respective early‐responding proteins may also contribute to synaptic vesicle cycle alterations in symptomatic AD." @default.
- W3156202211 created "2021-04-26" @default.
- W3156202211 creator A5009935278 @default.
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- W3156202211 creator A5086292280 @default.
- W3156202211 date "2021-04-19" @default.
- W3156202211 modified "2023-10-18" @default.
- W3156202211 title "Sequence of proteome profiles in preclinical and symptomatic Alzheimer's disease" @default.
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