Matches in SemOpenAlex for { <https://semopenalex.org/work/W31562046> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W31562046 endingPage "9" @default.
- W31562046 startingPage "505" @default.
- W31562046 abstract "To explore the effects of 2 major drug-resistant mechanisms in clinically isolated strains of extensively drug-resistant tuberculosis (XDR-MTB).Genomic DNA of 10 XDR-MTB strains isolated from Shanghai Pulmonary Hospital were extracted. The main gene mutations related to drug resistance and 15 SNPs unique to XDR-MTB clinical isolate KZN605 reported by the Broad Institute in USA were detected by sequencing. The changes of minimal inhibition concentration (MIC) of XDR-MTB isolates were detected before and after the addition of efflux pump inhibitors verapamil, CCCP and reserpine in liquid cultures.The mutation of rpoB, katG and rpsL occurred in all XDR-MTB strains. The mutation of gyrA, gyrB and rrs occurred in 9 strains, 2 strains and 6 strains respectively. There was no mutation of tlyA in all the strains. Most of the SNPs in KZN 605 strains were not detected in the clinical strains. The clinical strains showed no significant changes of MICs, except 1 strain for which the MIC of ofloxacin decreased by 16 times after addition of the efflux pump inhibitors.The gene mutations related to drug resistance are the key mechanism for the clinical XDR-MTB strains, while the efflux pumps partly play a role in the drug resistance to fluoroquinolones. The detailed mechanism of efflux pump mediated drug resistance to other anti-TB drugs needs further study." @default.
- W31562046 created "2016-06-24" @default.
- W31562046 creator A5025800767 @default.
- W31562046 creator A5029589252 @default.
- W31562046 creator A5065123885 @default.
- W31562046 creator A5075877965 @default.
- W31562046 creator A5087099599 @default.
- W31562046 date "2010-07-01" @default.
- W31562046 modified "2023-09-23" @default.
- W31562046 title "[The effects of gene mutation related to drug resistance and drug efflux pump in extensively drug-resistant tuberculosis clinical isolates]." @default.
- W31562046 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20979796" @default.
- W31562046 hasPublicationYear "2010" @default.
- W31562046 type Work @default.
- W31562046 sameAs 31562046 @default.
- W31562046 citedByCount "0" @default.
- W31562046 crossrefType "journal-article" @default.
- W31562046 hasAuthorship W31562046A5025800767 @default.
- W31562046 hasAuthorship W31562046A5029589252 @default.
- W31562046 hasAuthorship W31562046A5065123885 @default.
- W31562046 hasAuthorship W31562046A5075877965 @default.
- W31562046 hasAuthorship W31562046A5087099599 @default.
- W31562046 hasConcept C104317684 @default.
- W31562046 hasConcept C114851261 @default.
- W31562046 hasConcept C133936738 @default.
- W31562046 hasConcept C142724271 @default.
- W31562046 hasConcept C200082930 @default.
- W31562046 hasConcept C2777975735 @default.
- W31562046 hasConcept C2778049240 @default.
- W31562046 hasConcept C2778340795 @default.
- W31562046 hasConcept C2778512257 @default.
- W31562046 hasConcept C2780035454 @default.
- W31562046 hasConcept C2781069245 @default.
- W31562046 hasConcept C2994225774 @default.
- W31562046 hasConcept C501593827 @default.
- W31562046 hasConcept C501734568 @default.
- W31562046 hasConcept C54355233 @default.
- W31562046 hasConcept C71924100 @default.
- W31562046 hasConcept C86803240 @default.
- W31562046 hasConcept C89423630 @default.
- W31562046 hasConcept C98274493 @default.
- W31562046 hasConceptScore W31562046C104317684 @default.
- W31562046 hasConceptScore W31562046C114851261 @default.
- W31562046 hasConceptScore W31562046C133936738 @default.
- W31562046 hasConceptScore W31562046C142724271 @default.
- W31562046 hasConceptScore W31562046C200082930 @default.
- W31562046 hasConceptScore W31562046C2777975735 @default.
- W31562046 hasConceptScore W31562046C2778049240 @default.
- W31562046 hasConceptScore W31562046C2778340795 @default.
- W31562046 hasConceptScore W31562046C2778512257 @default.
- W31562046 hasConceptScore W31562046C2780035454 @default.
- W31562046 hasConceptScore W31562046C2781069245 @default.
- W31562046 hasConceptScore W31562046C2994225774 @default.
- W31562046 hasConceptScore W31562046C501593827 @default.
- W31562046 hasConceptScore W31562046C501734568 @default.
- W31562046 hasConceptScore W31562046C54355233 @default.
- W31562046 hasConceptScore W31562046C71924100 @default.
- W31562046 hasConceptScore W31562046C86803240 @default.
- W31562046 hasConceptScore W31562046C89423630 @default.
- W31562046 hasConceptScore W31562046C98274493 @default.
- W31562046 hasIssue "7" @default.
- W31562046 hasLocation W315620461 @default.
- W31562046 hasOpenAccess W31562046 @default.
- W31562046 hasPrimaryLocation W315620461 @default.
- W31562046 hasRelatedWork W1148382174 @default.
- W31562046 hasRelatedWork W1619289482 @default.
- W31562046 hasRelatedWork W193992003 @default.
- W31562046 hasRelatedWork W2055039460 @default.
- W31562046 hasRelatedWork W2115294037 @default.
- W31562046 hasRelatedWork W2119282038 @default.
- W31562046 hasRelatedWork W2168896139 @default.
- W31562046 hasRelatedWork W2357762806 @default.
- W31562046 hasRelatedWork W2551685445 @default.
- W31562046 hasRelatedWork W2555761030 @default.
- W31562046 hasRelatedWork W2571252808 @default.
- W31562046 hasRelatedWork W2743259736 @default.
- W31562046 hasRelatedWork W2795821045 @default.
- W31562046 hasRelatedWork W2910724770 @default.
- W31562046 hasRelatedWork W2947818689 @default.
- W31562046 hasRelatedWork W2965120927 @default.
- W31562046 hasRelatedWork W2980015592 @default.
- W31562046 hasRelatedWork W2988954302 @default.
- W31562046 hasRelatedWork W3125121066 @default.
- W31562046 hasRelatedWork W3181976771 @default.
- W31562046 hasVolume "33" @default.
- W31562046 isParatext "false" @default.
- W31562046 isRetracted "false" @default.
- W31562046 magId "31562046" @default.
- W31562046 workType "article" @default.