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• W3156253900 startingPage "2303" @default.
• W3156253900 abstract "Gastrointestinal (GI) malignancies account for substantial mortality and morbidity worldwide. They are generally promoted by dysregulated signal transduction and epigenetic pathways, which are controlled by specific enzymes. Recent studies demonstrated that histone deacetylases (HDACs) together with DNA methyltransferases (DNMTs) have crucial roles in the signal transduction/epigenetic pathways in GI regulation. In this review, we discuss various enzyme targets and their functional mechanisms responsible for the regulatory processes of GI malignancies. We also discuss the epigenetic therapeutic targets that are mainly facilitated by DNMT and HDAC inhibitors, which have functional consequences and clinical outcomes for GI malignancies." @default.
• W3156253900 created "2021-04-26" @default.
• W3156253900 creator A5005200774 @default.
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• W3156253900 date "2021-10-01" @default.
• W3156253900 modified "2023-09-23" @default.
• W3156253900 title "Epigenetics and therapeutic targets in gastrointestinal malignancies" @default.
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• W3156253900 doi "https://doi.org/10.1016/j.drudis.2021.04.013" @default.
• W3156253900 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33895313" @default.
• W3156253900 hasPublicationYear "2021" @default.

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