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- W3156261797 abstract "The MED1 subunit has been shown to mediate ligand-dependent binding of the Mediator coactivator complex to multiple nuclear receptors, including the adipogenic PPARγ, and to play an essential role in ectopic PPARγ-induced adipogenesis of mouse embryonic fibroblasts. However, the precise roles of MED1, and its various domains, at various stages of adipogenesis and in adipose tissue have been unclear. Here, after establishing requirements for MED1, including specific domains, for differentiation of 3T3L1 cells and both primary white and brown preadipocytes, we used multiple genetic approaches to assess requirements for MED1 in adipocyte formation, maintenance, and function in mice. We show that MED1 is indeed essential for the differentiation and/or function of both brown and white adipocytes, as its absence in these cells leads to, respectively, defective brown fat function and lipodystrophy. This work establishes MED1 as an essential transcriptional coactivator that ensures homeostatic functions of adipocytes." @default.
- W3156261797 created "2021-04-26" @default.
- W3156261797 creator A5004942810 @default.
- W3156261797 creator A5005776117 @default.
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- W3156261797 creator A5025650110 @default.
- W3156261797 creator A5035850116 @default.
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- W3156261797 creator A5039514008 @default.
- W3156261797 creator A5047214685 @default.
- W3156261797 creator A5065622211 @default.
- W3156261797 date "2021-04-22" @default.
- W3156261797 modified "2023-10-14" @default.
- W3156261797 title "Critical roles of transcriptional coactivator MED1 in the formation and function of mouse adipose tissues" @default.
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