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- W3156264142 endingPage "552" @default.
- W3156264142 startingPage "552" @default.
- W3156264142 abstract "Double-stranded breaks (DSB), the most toxic DNA lesions, are either a consequence of cellular metabolism, programmed as in during V(D)J recombination, or induced by anti-tumoral therapies or accidental genotoxic exposure. One origin of DSB sources is replicative stress, a major source of genome instability, especially when the integrity of the replication forks is not properly guaranteed. To complete stalled replication, restarting the fork requires complex molecular mechanisms, such as protection, remodeling, and processing. Recently, a link has been made between DNA damage accumulation and inflammation. Indeed, defects in DNA repair or in replication can lead to the release of DNA fragments in the cytosol. The recognition of this self-DNA by DNA sensors leads to the production of inflammatory factors. This beneficial response activating an innate immune response and destruction of cells bearing DNA damage may be considered as a novel part of DNA damage response. However, upon accumulation of DNA damage, a chronic inflammatory cellular microenvironment may lead to inflammatory pathologies, aging, and progression of tumor cells. Progress in understanding the molecular mechanisms of DNA damage repair, replication stress, and cytosolic DNA production would allow to propose new therapeutical strategies against cancer or inflammatory diseases associated with aging. In this review, we describe the mechanisms involved in DSB repair, the replicative stress management, and its consequences. We also focus on new emerging links between key components of the nuclear envelope, the lamins, and DNA repair, management of replicative stress, and inflammation." @default.
- W3156264142 created "2021-04-26" @default.
- W3156264142 creator A5004600775 @default.
- W3156264142 creator A5028534448 @default.
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- W3156264142 creator A5040076671 @default.
- W3156264142 creator A5063075161 @default.
- W3156264142 creator A5081210150 @default.
- W3156264142 date "2021-04-09" @default.
- W3156264142 modified "2023-10-02" @default.
- W3156264142 title "A Link between Replicative Stress, Lamin Proteins, and Inflammation" @default.
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