FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3156281836> ?p ?o ?g. }

• W3156281836 abstract "Abstract Pancreatic ductal adenocarcinoma (PDAC) is the most common form of pancreatic cancer with an abysmal prognosis rate over the last few decades. Early diagnosis and prevention could effectively combat this malignancy. Therefore, it is crucial to discover potential biomarkers to identify asymptomatic premalignant or early malignant tumors of PDAC. Gene expression analysis is a powerful technique to identify candidate biomarkers involved in disease progression. In the present study, five independent gene expression datasets, including 321 PDAC tissues and 208 adjacent non-cancerous tissue samples, were subjected to statistical and bioinformatics analysis. A total of 20 differentially expressed genes (DEGs) were identified in PDAC tissues compared to non-cancerous tissue samples. Gene ontology and pathway enrichment analysis showed that DEGs were mainly enriched in extracellular matrix (ECM), cell adhesion, ECM–receptor interaction, and focal adhesion signaling. The protein–protein interaction network was constructed, and the hub genes were evaluated. Collagen type XII alpha 1 chain (COL12A1), fibronectin 1 (FN1), integrin subunit alpha 2 (ITGA2), laminin subunit beta 3 (LAMB3), laminin subunit gamma 2 (LAMC2), thrombospondin 2 (THBS2), and versican (VCAN) were identified as hub genes. The correlation analysis revealed that identified hub genes were significantly interconnected. Wherein COL12A1, FN1, ITGA2, LAMB3, LAMC2, and THBS2 were significantly associated with PDAC pathological stages. The Kaplan–Meier survival plots revealed that ITGA2, LAMB3, and LAMC2 expression were inversely correlated with a prolonged patient survival period. Furthermore, the Human Protein Atlas database was used to validate the expression and cellular origins of hub genes encoded proteins. The protein expression of hub genes was higher in pancreatic cancer tissue than in normal pancreatic tissue samples, wherein ITGA2, LAMB3, and LAMC2 were exclusively expressed in pancreatic cancer cells. Pancreatic cancer cell-specific expression of these three proteins may play pleiotropic roles in cancer progression. Our results collectively suggest that ITGA2, LAMB3, and LAMC2 could provide deep insights into pancreatic carcinogenesis molecular mechanisms and provide attractive therapeutic targets." @default.
• W3156281836 created "2021-04-26" @default.
• W3156281836 creator A5033744969 @default.
• W3156281836 creator A5038103101 @default.
• W3156281836 creator A5068582675 @default.
• W3156281836 creator A5070168885 @default.
• W3156281836 creator A5073129629 @default.
• W3156281836 creator A5085700951 @default.
• W3156281836 date "2021-05-18" @default.
• W3156281836 modified "2023-10-16" @default.
• W3156281836 title "ITGA2, LAMB3, and LAMC2 may be the potential therapeutic targets in pancreatic ductal adenocarcinoma: an integrated bioinformatics analysis" @default.
• W3156281836 cites W1560020441 @default.
• W3156281836 cites W1904240020 @default.
• W3156281836 cites W1992280242 @default.
• W3156281836 cites W1993782263 @default.
• W3156281836 cites W2024858956 @default.
• W3156281836 cites W2096173332 @default.
• W3156281836 cites W2109995938 @default.
• W3156281836 cites W2111895881 @default.
• W3156281836 cites W2158217645 @default.
• W3156281836 cites W2159675211 @default.
• W3156281836 cites W2194697488 @default.
• W3156281836 cites W2336715782 @default.
• W3156281836 cites W2408483783 @default.
• W3156281836 cites W243476585 @default.
• W3156281836 cites W2460832567 @default.
• W3156281836 cites W2514712994 @default.
• W3156281836 cites W2521065763 @default.
• W3156281836 cites W2590390825 @default.
• W3156281836 cites W2749613778 @default.
• W3156281836 cites W2751089373 @default.
• W3156281836 cites W2772870171 @default.
• W3156281836 cites W2781525129 @default.
• W3156281836 cites W2782369003 @default.
• W3156281836 cites W2783393271 @default.
• W3156281836 cites W2801349845 @default.
• W3156281836 cites W2885493122 @default.
• W3156281836 cites W2889646458 @default.
• W3156281836 cites W2889990912 @default.
• W3156281836 cites W2906679447 @default.
• W3156281836 cites W2906902559 @default.
• W3156281836 cites W2913124609 @default.
• W3156281836 cites W2917830580 @default.
• W3156281836 cites W2944090732 @default.
• W3156281836 cites W2946657092 @default.
• W3156281836 cites W2968449628 @default.
• W3156281836 cites W3007119058 @default.
• W3156281836 cites W3035030734 @default.
• W3156281836 cites W3096828292 @default.
• W3156281836 cites W4295846302 @default.
• W3156281836 doi "https://doi.org/10.1038/s41598-021-90077-x" @default.
• W3156281836 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8131351" @default.
• W3156281836 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34007003" @default.
• W3156281836 hasPublicationYear "2021" @default.
• W3156281836 type Work @default.
• W3156281836 sameAs 3156281836 @default.
• W3156281836 citedByCount "23" @default.
• W3156281836 countsByYear W31562818362021 @default.
• W3156281836 countsByYear W31562818362022 @default.
• W3156281836 countsByYear W31562818362023 @default.
• W3156281836 crossrefType "journal-article" @default.
• W3156281836 hasAuthorship W3156281836A5033744969 @default.
• W3156281836 hasAuthorship W3156281836A5038103101 @default.
• W3156281836 hasAuthorship W3156281836A5068582675 @default.
• W3156281836 hasAuthorship W3156281836A5070168885 @default.
• W3156281836 hasAuthorship W3156281836A5073129629 @default.
• W3156281836 hasAuthorship W3156281836A5085700951 @default.
• W3156281836 hasBestOaLocation W31562818361 @default.
• W3156281836 hasConcept C104317684 @default.
• W3156281836 hasConcept C121608353 @default.
• W3156281836 hasConcept C1491633281 @default.
• W3156281836 hasConcept C150194340 @default.
• W3156281836 hasConcept C18431079 @default.
• W3156281836 hasConcept C189165786 @default.
• W3156281836 hasConcept C195687474 @default.
• W3156281836 hasConcept C2779814568 @default.
• W3156281836 hasConcept C2780210213 @default.
• W3156281836 hasConcept C502942594 @default.
• W3156281836 hasConcept C54355233 @default.
• W3156281836 hasConcept C86492073 @default.
• W3156281836 hasConcept C86803240 @default.
• W3156281836 hasConceptScore W3156281836C104317684 @default.
• W3156281836 hasConceptScore W3156281836C121608353 @default.
• W3156281836 hasConceptScore W3156281836C1491633281 @default.
• W3156281836 hasConceptScore W3156281836C150194340 @default.
• W3156281836 hasConceptScore W3156281836C18431079 @default.
• W3156281836 hasConceptScore W3156281836C189165786 @default.
• W3156281836 hasConceptScore W3156281836C195687474 @default.
• W3156281836 hasConceptScore W3156281836C2779814568 @default.
• W3156281836 hasConceptScore W3156281836C2780210213 @default.
• W3156281836 hasConceptScore W3156281836C502942594 @default.
• W3156281836 hasConceptScore W3156281836C54355233 @default.
• W3156281836 hasConceptScore W3156281836C86492073 @default.
• W3156281836 hasConceptScore W3156281836C86803240 @default.
• W3156281836 hasIssue "1" @default.
• W3156281836 hasLocation W31562818361 @default.
• W3156281836 hasLocation W31562818362 @default.
• W3156281836 hasLocation W31562818363 @default.
• W3156281836 hasOpenAccess W3156281836 @default.
• W3156281836 hasPrimaryLocation W31562818361 @default.

• next