Matches in SemOpenAlex for { <https://semopenalex.org/work/W3156283510> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W3156283510 abstract "Aim: The aim of this experimental study was to evaluate the possible cytoprotective effects of renin-angiotensin-aldosterone system (RAAS) blockade, captopril (10 mg/kg), telmisartan (10 mg/kg), and a proton-pump inhibitor (lansoprazole) on intestinal injury induced by indomethacin in rats. Materials and Methods: This effect was evaluated through the assessment of intestinal inflammatory biomarkers and oxidative stress parameters. Forty adult male albino rats weighing 170–200 g were used and divided equally into five groups. After the treatment, the following were assessed: Myeloperoxidase (MPO) enzyme activity, pro-inflammatory (interleukin-1beta [IL-1 β]) content and anti-inflammatory (IL-10) content, malondialdehyde (MDA) content, reduced glutathione (GSH) content, and superoxide dismutase (SOD) enzyme activity, and histopathological examination of the intestinal tissues was conducted. Results: Indomethacin group induced a significant increase in MDA content, also in inflammatory biomarker (MPO enzyme activity, IL-1 β content, and IL-10 content) compared to normal control, while indomethacin group induced a significant decrease in GSH content, SOD enzyme activity compared to normal control group. Captopril, telmisartan, lansoprazole administration before indomethacin-induced significant increase in GSH content, SOD enzyme activity, while induced significant decrease in MDA content as well as in inflammatory biomarker compared to indomethacin group, which indicate the antioxidant, anti-inflammatory effects, and the gastroprotective properties of RAAS blockers, which also shown in the histopathological examination of intestinal tissues. Conclusion: This study showed the possible antioxidant and anti-inflammatory effects as well as the gastroprotective properties of RAAS blockers. Telmisartan has more antioxidant and anti-inflammatory effect as well as cytoprotective action than captopril." @default.
- W3156283510 created "2021-04-26" @default.
- W3156283510 creator A5016993299 @default.
- W3156283510 creator A5042562094 @default.
- W3156283510 creator A5069807402 @default.
- W3156283510 creator A5072063911 @default.
- W3156283510 date "2021-01-01" @default.
- W3156283510 modified "2023-09-23" @default.
- W3156283510 title "Effect of renin-angiotensin-aldosterone system blockade on intestinal injury induced by indomethacin in rats" @default.
- W3156283510 doi "https://doi.org/10.4103/ljms.ljms_95_20" @default.
- W3156283510 hasPublicationYear "2021" @default.
- W3156283510 type Work @default.
- W3156283510 sameAs 3156283510 @default.
- W3156283510 citedByCount "0" @default.
- W3156283510 crossrefType "journal-article" @default.
- W3156283510 hasAuthorship W3156283510A5016993299 @default.
- W3156283510 hasAuthorship W3156283510A5042562094 @default.
- W3156283510 hasAuthorship W3156283510A5069807402 @default.
- W3156283510 hasAuthorship W3156283510A5072063911 @default.
- W3156283510 hasConcept C126322002 @default.
- W3156283510 hasConcept C134018914 @default.
- W3156283510 hasConcept C181199279 @default.
- W3156283510 hasConcept C185592680 @default.
- W3156283510 hasConcept C203565725 @default.
- W3156283510 hasConcept C2775838275 @default.
- W3156283510 hasConcept C2776151105 @default.
- W3156283510 hasConcept C2776914184 @default.
- W3156283510 hasConcept C2778004101 @default.
- W3156283510 hasConcept C2778401633 @default.
- W3156283510 hasConcept C2778525890 @default.
- W3156283510 hasConcept C2778760513 @default.
- W3156283510 hasConcept C2779479957 @default.
- W3156283510 hasConcept C2779716603 @default.
- W3156283510 hasConcept C2780829032 @default.
- W3156283510 hasConcept C538909803 @default.
- W3156283510 hasConcept C55493867 @default.
- W3156283510 hasConcept C71924100 @default.
- W3156283510 hasConcept C84393581 @default.
- W3156283510 hasConcept C98274493 @default.
- W3156283510 hasConceptScore W3156283510C126322002 @default.
- W3156283510 hasConceptScore W3156283510C134018914 @default.
- W3156283510 hasConceptScore W3156283510C181199279 @default.
- W3156283510 hasConceptScore W3156283510C185592680 @default.
- W3156283510 hasConceptScore W3156283510C203565725 @default.
- W3156283510 hasConceptScore W3156283510C2775838275 @default.
- W3156283510 hasConceptScore W3156283510C2776151105 @default.
- W3156283510 hasConceptScore W3156283510C2776914184 @default.
- W3156283510 hasConceptScore W3156283510C2778004101 @default.
- W3156283510 hasConceptScore W3156283510C2778401633 @default.
- W3156283510 hasConceptScore W3156283510C2778525890 @default.
- W3156283510 hasConceptScore W3156283510C2778760513 @default.
- W3156283510 hasConceptScore W3156283510C2779479957 @default.
- W3156283510 hasConceptScore W3156283510C2779716603 @default.
- W3156283510 hasConceptScore W3156283510C2780829032 @default.
- W3156283510 hasConceptScore W3156283510C538909803 @default.
- W3156283510 hasConceptScore W3156283510C55493867 @default.
- W3156283510 hasConceptScore W3156283510C71924100 @default.
- W3156283510 hasConceptScore W3156283510C84393581 @default.
- W3156283510 hasConceptScore W3156283510C98274493 @default.
- W3156283510 hasLocation W31562835101 @default.
- W3156283510 hasOpenAccess W3156283510 @default.
- W3156283510 hasPrimaryLocation W31562835101 @default.
- W3156283510 hasRelatedWork W10020646 @default.
- W3156283510 hasRelatedWork W13856530 @default.
- W3156283510 hasRelatedWork W1769405 @default.
- W3156283510 hasRelatedWork W20413612 @default.
- W3156283510 hasRelatedWork W20703465 @default.
- W3156283510 hasRelatedWork W20816310 @default.
- W3156283510 hasRelatedWork W2826896 @default.
- W3156283510 hasRelatedWork W5327394 @default.
- W3156283510 hasRelatedWork W5991107 @default.
- W3156283510 hasRelatedWork W8610565 @default.
- W3156283510 isParatext "false" @default.
- W3156283510 isRetracted "false" @default.
- W3156283510 magId "3156283510" @default.
- W3156283510 workType "article" @default.