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- W3156294264 abstract "Proprotein Convertase Subtilisin/Kexin type 9 (PCSK-9), the new biomarker interfering in lipid homeostasis, has not been explored among sub-Saharan African receiving maintenance hemodialysis. The aim of this study was to investigate the association between PCSK-9, dyslipidemia and risk of cardiovascular events in a population of black Africans. A case-control observational study was conducted between August 2016 and July 2020 in six hemodialysis centers in the city of Kinshasa, the Democratic Republic of Congo. We measured serum PCSK-9 by Elisa and lipid levels in 286 CKD-HD patients and compared them to 296 non-CKD subjects. The gender-specific models of the Framingham predictive instrument were used for predicting cardiac events. Serum PCSK-9, TC, LDL c and TG were significantly higher in CKD-HD group compared to the control group. By contrast, the HDL c level was significantly lower in CKD-HD patients compared to non-CKD group. The TC, LDL-c and TG increase significantly at tertile 3 (P <0.001) while HDL-c decreases significantly at the same tertile (P <0.001). In multivariate logistic regression analysis, CKD-HD status and PCSK-9 remained as independent determinants of risk for cardiovascular events. Compared to non CKD subjects, the likelihood of having a cardiovascular event in CKD-HD group is 37 times higher [37.25 (11.33-122.44); P <0.001)]. Being in PCSK-9 tertile 2 [P <0.001; 5.58 (2.19-14.22)] and PCSK-9 tertile 3 [P <0.001; 16.96 (6.51-44.18)] is associated with 6 and 17 OR, respectively. The level of PCSK-9 is associated with increased risk of cardiovascular events in haemodialyzed patients, independently of traditional potential confounders." @default.
- W3156294264 created "2021-04-26" @default.
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- W3156294264 date "2021-04-01" @default.
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- W3156294264 title "POS-579 CIRCULATING PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 INDEPENDENTLY PREDICT RISK OF CARDIOVASCULAR EVENTS IN HEMODIALYSED BLACK AFRICAN PATIENTS: A CASE-CONTROL STUDY USING THE FRAMINGHAM PREDICTIVE INSTRUMENT" @default.
- W3156294264 doi "https://doi.org/10.1016/j.ekir.2021.03.608" @default.
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