FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3156337147> ?p ?o ?g. }

• W3156337147 abstract "Mendelian randomization (MR) can estimate the causal effect for a risk factor on a complex disease using genetic variants as instrument variables (IVs). A variety of generalized MR methods have been proposed to integrate results arising from multiple IVs in order to increase power. One of the methods constructs the genetic score (GS) by a linear combination of the multiple IVs using the multiple regression model, which was applied in medical researches broadly. However, GS-based MR requires individual-level data, which greatly limit its application in clinical research. We propose an alternative method called Mendelian Randomization with Refined Instrumental Variable from Genetic Score (MR-RIVER) to construct a genetic IV by integrating multiple genetic variants based on summarized results, rather than individual data. Compared with inverse-variance weighted (IVW) and generalized summary-data-based Mendelian randomization (GSMR), MR-RIVER maintained the type I error, while possessing more statistical power than the competing methods. MR-RIVER also presented smaller biases and mean squared errors, compared to the IVW and GSMR. We further applied the proposed method to estimate the effects of blood metabolites on educational attainment, by integrating results from several publicly available resources. MR-RIVER provided robust results under different LD prune criteria and identified three metabolites associated with years of schooling and additional 15 metabolites with indirect mediation effects through butyrylcarnitine. MR-RIVER, which extends score-based MR to summarized results in lieu of individual data and incorporates multiple correlated IVs, provided a more accurate and powerful means for the discovery of novel risk factors." @default.
• W3156337147 created "2021-04-26" @default.
• W3156337147 creator A5022823961 @default.
• W3156337147 creator A5023552664 @default.
• W3156337147 creator A5027061852 @default.
• W3156337147 creator A5028249243 @default.
• W3156337147 creator A5028462736 @default.
• W3156337147 creator A5064842058 @default.
• W3156337147 creator A5066874159 @default.
• W3156337147 creator A5068299759 @default.
• W3156337147 creator A5081350789 @default.
• W3156337147 creator A5081352122 @default.
• W3156337147 creator A5084851606 @default.
• W3156337147 creator A5090261081 @default.
• W3156337147 date "2021-03-17" @default.
• W3156337147 modified "2023-10-09" @default.
• W3156337147 title "Mendelian Randomization With Refined Instrumental Variables From Genetic Score Improves Accuracy and Reduces Bias" @default.
• W3156337147 cites W1905058580 @default.
• W3156337147 cites W1965211978 @default.
• W3156337147 cites W1965776430 @default.
• W3156337147 cites W1984000875 @default.
• W3156337147 cites W1989080674 @default.
• W3156337147 cites W1989568128 @default.
• W3156337147 cites W1996299724 @default.
• W3156337147 cites W2004747012 @default.
• W3156337147 cites W2007121611 @default.
• W3156337147 cites W2030682156 @default.
• W3156337147 cites W2060324229 @default.
• W3156337147 cites W2073177465 @default.
• W3156337147 cites W2106036991 @default.
• W3156337147 cites W2112203259 @default.
• W3156337147 cites W2115179369 @default.
• W3156337147 cites W2116868464 @default.
• W3156337147 cites W2116908385 @default.
• W3156337147 cites W2118743532 @default.
• W3156337147 cites W2127065386 @default.
• W3156337147 cites W2127767012 @default.
• W3156337147 cites W2128736149 @default.
• W3156337147 cites W2142161268 @default.
• W3156337147 cites W2162204400 @default.
• W3156337147 cites W2198755677 @default.
• W3156337147 cites W2300236549 @default.
• W3156337147 cites W2325761966 @default.
• W3156337147 cites W2346626662 @default.
• W3156337147 cites W2401811918 @default.
• W3156337147 cites W2413861456 @default.
• W3156337147 cites W2581245397 @default.
• W3156337147 cites W2604218568 @default.
• W3156337147 cites W2613799776 @default.
• W3156337147 cites W2921209497 @default.
• W3156337147 cites W2951286101 @default.
• W3156337147 cites W2953121869 @default.
• W3156337147 cites W2963964823 @default.
• W3156337147 cites W3014191903 @default.
• W3156337147 cites W4292811746 @default.
• W3156337147 doi "https://doi.org/10.3389/fgene.2021.618829" @default.
• W3156337147 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8044958" @default.
• W3156337147 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33868364" @default.
• W3156337147 hasPublicationYear "2021" @default.
• W3156337147 type Work @default.
• W3156337147 sameAs 3156337147 @default.
• W3156337147 citedByCount "5" @default.
• W3156337147 countsByYear W31563371472022 @default.
• W3156337147 countsByYear W31563371472023 @default.
• W3156337147 crossrefType "journal-article" @default.
• W3156337147 hasAuthorship W3156337147A5022823961 @default.
• W3156337147 hasAuthorship W3156337147A5023552664 @default.
• W3156337147 hasAuthorship W3156337147A5027061852 @default.
• W3156337147 hasAuthorship W3156337147A5028249243 @default.
• W3156337147 hasAuthorship W3156337147A5028462736 @default.
• W3156337147 hasAuthorship W3156337147A5064842058 @default.
• W3156337147 hasAuthorship W3156337147A5066874159 @default.
• W3156337147 hasAuthorship W3156337147A5068299759 @default.
• W3156337147 hasAuthorship W3156337147A5081350789 @default.
• W3156337147 hasAuthorship W3156337147A5081352122 @default.
• W3156337147 hasAuthorship W3156337147A5084851606 @default.
• W3156337147 hasAuthorship W3156337147A5090261081 @default.
• W3156337147 hasBestOaLocation W31563371471 @default.
• W3156337147 hasConcept C104317684 @default.
• W3156337147 hasConcept C105795698 @default.
• W3156337147 hasConcept C135763542 @default.
• W3156337147 hasConcept C162144332 @default.
• W3156337147 hasConcept C2779901538 @default.
• W3156337147 hasConcept C2993967602 @default.
• W3156337147 hasConcept C33923547 @default.
• W3156337147 hasConcept C41008148 @default.
• W3156337147 hasConcept C41587187 @default.
• W3156337147 hasConcept C54355233 @default.
• W3156337147 hasConcept C86803240 @default.
• W3156337147 hasConceptScore W3156337147C104317684 @default.
• W3156337147 hasConceptScore W3156337147C105795698 @default.
• W3156337147 hasConceptScore W3156337147C135763542 @default.
• W3156337147 hasConceptScore W3156337147C162144332 @default.
• W3156337147 hasConceptScore W3156337147C2779901538 @default.
• W3156337147 hasConceptScore W3156337147C2993967602 @default.
• W3156337147 hasConceptScore W3156337147C33923547 @default.
• W3156337147 hasConceptScore W3156337147C41008148 @default.
• W3156337147 hasConceptScore W3156337147C41587187 @default.
• W3156337147 hasConceptScore W3156337147C54355233 @default.
• W3156337147 hasConceptScore W3156337147C86803240 @default.

• next