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• W3156356732 abstract "Susac’s syndrome, a rare autoimmune vasculo-occlusive disease, may pose a diagnostic challenge and result in a devastating ocular and systemic outcome. Our study identifies a new retinal finding and evaluates disease outcome. We aimed to assess clinical and imaging findings, systemic manifestations and disease outcome in patients with ocular Susac’s syndrome under immunosuppressive/immunomodulation therapies. Retrospective tertiary center study including patients with a diagnosis of Susac’s syndrome with >12 months follow up. Medical record review including ocular, neurological and auditory clinical and imaging findings, and treatment modalities. Main outcome measures were clinical manifestations and disease outcome. Seven patients (14 eyes) with a mean age of 34.1 years were included. Mean follow-up was 31.9 months (12.4–72.4). All had bilateral ocular disease. Retinal microaneurysms, a new ocular finding, were demonstrated in 5 patients and persisted at the final visit. In 5 eyes, they further extended during follow-up. All were treated with immunosuppressive drugs and 5/7 additional immunomodulation therapy. At last examination, best corrected visual acuity was >20/40 in all eyes, 1/10 eyes had visual field deterioration, no eye had active ocular disease, all patients achieved neurological stability, and 1 patient had auditory deterioration. Retinal microaneurysms, a new ocular finding in Susac’s syndrome, were present in most of our patients, indicating ischemic retinal damage. Immunosuppressive and immunomodulation therapies seem to be highly effective in the control of disease activity." @default.
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• W3156356732 date "2021-04-20" @default.
• W3156356732 modified "2023-10-09" @default.
• W3156356732 title "Susac’s syndrome – A new ocular finding and disease outcome" @default.
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• W3156356732 doi "https://doi.org/10.1038/s41433-021-01464-7" @default.
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