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• W3156358629 abstract "Recently we reported the immune-potentiating capacity of a Chlamydia nanovaccine (PLGA-rMOMP) comprising rMOMP (recombinant major outer membrane protein) encapsulated in extended-releasing PLGA [poly (D, L-lactide-co-glycolide) (85:15)] nanoparticles. Here we hypothesized that PLGA-rMOMP would bolster immune-effector mechanisms to confer protective efficacy in mice against a Chlamydia muridarum genital challenge and re-challenge. Female BALB/c mice received three immunizations, either subcutaneously (SC) or intranasally (IN), before receiving an intravaginal challenge with C. muridarum on day 49 and a re-challenge on day 170. Both the SC and IN immunization routes protected mice against genital challenge with enhanced protection after a re-challenge, especially in the SC mice. The nanovaccine induced robust antigen-specific Th1 (IFN-γ, IL-2) and IL-17 cytokines plus CD4 + proliferating T-cells and memory (CD44 high CD62L high ) and effector (CD44 high CD62L low ) phenotypes in immunized mice. Parallel induction of antigen-specific systemic and mucosal Th1 (IgG2a, IgG2b), Th2 (IgG1), and IgA antibodies were also noted. Importantly, immunized mice produced highly functional Th1 avidity and serum antibodies that neutralized C. muridarum infectivity of McCoy fibroblasts in-vitro that correlated with their respective protection levels. The SC, rather than the IN immunization route, triggered higher cellular and humoral immune effectors that improved mice protection against genital C. muridarum. We report for the first time that the extended-releasing PLGA 85:15 encapsulated rMOMP nanovaccine confers protective immunity in mice against genital Chlamydia and advances the potential towards acquiring a nano-based Chlamydia vaccine." @default.
• W3156358629 created "2021-04-26" @default.
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• W3156358629 date "2021-04-14" @default.
• W3156358629 modified "2023-10-08" @default.
• W3156358629 title "Encapsulation of Recombinant MOMP in Extended-Releasing PLGA 85:15 Nanoparticles Confer Protective Immunity Against a Chlamydia muridarum Genital Challenge and Re-Challenge" @default.
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• W3156358629 cites W1702002026 @default.
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• W3156358629 cites W1873165610 @default.
• W3156358629 cites W1892690144 @default.
• W3156358629 cites W1965647100 @default.
• W3156358629 cites W1971389070 @default.
• W3156358629 cites W1974299683 @default.
• W3156358629 cites W1989434534 @default.
• W3156358629 cites W1998036925 @default.
• W3156358629 cites W2022922808 @default.
• W3156358629 cites W2024954594 @default.
• W3156358629 cites W2025147603 @default.
• W3156358629 cites W2025656083 @default.
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• W3156358629 cites W2029772952 @default.
• W3156358629 cites W2045127348 @default.
• W3156358629 cites W2062533513 @default.
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• W3156358629 cites W2149612154 @default.
• W3156358629 cites W2156874418 @default.
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• W3156358629 cites W2203910881 @default.
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• W3156358629 cites W2290290566 @default.
• W3156358629 cites W2527863850 @default.
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• W3156358629 cites W2590164387 @default.
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• W3156358629 cites W2809395624 @default.
• W3156358629 cites W2887857161 @default.
• W3156358629 cites W2891397633 @default.
• W3156358629 cites W2891472790 @default.
• W3156358629 cites W2895497426 @default.
• W3156358629 cites W2896926421 @default.
• W3156358629 cites W2900294641 @default.
• W3156358629 cites W2913112953 @default.
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• W3156358629 doi "https://doi.org/10.3389/fimmu.2021.660932" @default.
• W3156358629 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8081181" @default.
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• W3156358629 hasPublicationYear "2021" @default.
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