Matches in SemOpenAlex for { <https://semopenalex.org/work/W3156417703> ?p ?o ?g. }
- W3156417703 endingPage "5314" @default.
- W3156417703 startingPage "5303" @default.
- W3156417703 abstract "Relapse susceptibility in women with substance use disorders (SUDs) has been linked to the estrogen, 17β-estradiol (E2). Our previous findings in female rats suggest that the influence of E2 on cocaine seeking can be localized to the prelimbic prefrontal cortex (PrL-PFC). Here, we investigated the receptor mechanisms through which E2 regulates the reinstatement of extinguished cocaine seeking. Sexually mature female rats underwent intravenous cocaine self-administration (0.5 mg/inf; 14 × 2 h daily) and extinction, and then were ovariectomized before reinstatement testing. E2 (10 µg/kg, i.p.) alone did not reinstate cocaine seeking, but it potentiated reinstatement when combined with an otherwise subthreshold priming dose of cocaine. A similar effect was observed following intra-PrL-PFC microinfusions of E2 and by systemic or intra-PrL-PFC administration of the estrogen receptor (ER)β agonist, DPN, but not agonists at ERα or the G-protein-coupled ER1 (GPER1). By contrast, E2-potentiated reinstatement was prevented by intra-PrL-PFC microinfusions of the ERβ antagonist, MPP, or the GPER1 antagonist, G15, but not an ERα antagonist. Whole-cell recordings in PrL-PFC layer (L)5/6 pyramidal neurons revealed that E2 decreases the frequency, but not amplitude, of GABA<sub>A</sub>-dependent miniature IPSCs (mIPSC). As was the case with E2-potentiated reinstatement, E2 reductions in mIPSC frequency were prevented by ERβ and GPER1, but not ERα, antagonists and mimicked by ERβ, but not GPER1, agonists. Altogether, the findings suggest that E2 activates ERβ and GPER1 in the PrL-PFC to attenuate the GABA-mediated constraint of key outputs that mediate cocaine seeking." @default.
- W3156417703 created "2021-04-26" @default.
- W3156417703 creator A5002920186 @default.
- W3156417703 creator A5016373888 @default.
- W3156417703 creator A5043082699 @default.
- W3156417703 creator A5049870310 @default.
- W3156417703 creator A5051811837 @default.
- W3156417703 creator A5054761345 @default.
- W3156417703 creator A5067939194 @default.
- W3156417703 creator A5077757829 @default.
- W3156417703 date "2021-04-20" @default.
- W3156417703 modified "2023-10-18" @default.
- W3156417703 title "Estradiol Regulation of the Prelimbic Cortex and the Reinstatement of Cocaine Seeking in Female Rats" @default.
- W3156417703 cites W1516762603 @default.
- W3156417703 cites W1566202711 @default.
- W3156417703 cites W1786781528 @default.
- W3156417703 cites W1889428062 @default.
- W3156417703 cites W1969528791 @default.
- W3156417703 cites W1971991982 @default.
- W3156417703 cites W1972171500 @default.
- W3156417703 cites W1974333168 @default.
- W3156417703 cites W1978652575 @default.
- W3156417703 cites W1978826948 @default.
- W3156417703 cites W1983292996 @default.
- W3156417703 cites W1983793618 @default.
- W3156417703 cites W1994127157 @default.
- W3156417703 cites W1998518744 @default.
- W3156417703 cites W2002962562 @default.
- W3156417703 cites W2002978772 @default.
- W3156417703 cites W2010307191 @default.
- W3156417703 cites W2012302074 @default.
- W3156417703 cites W2015866420 @default.
- W3156417703 cites W2016976563 @default.
- W3156417703 cites W2018964300 @default.
- W3156417703 cites W2019656315 @default.
- W3156417703 cites W2036502391 @default.
- W3156417703 cites W2039556738 @default.
- W3156417703 cites W2039924079 @default.
- W3156417703 cites W2042240432 @default.
- W3156417703 cites W2043545748 @default.
- W3156417703 cites W2045379279 @default.
- W3156417703 cites W2054194137 @default.
- W3156417703 cites W2064718941 @default.
- W3156417703 cites W2067626305 @default.
- W3156417703 cites W2069849707 @default.
- W3156417703 cites W2070472535 @default.
- W3156417703 cites W2070581367 @default.
- W3156417703 cites W2083339107 @default.
- W3156417703 cites W2086450395 @default.
- W3156417703 cites W2091757374 @default.
- W3156417703 cites W2092557252 @default.
- W3156417703 cites W2096568143 @default.
- W3156417703 cites W2103057436 @default.
- W3156417703 cites W2118795962 @default.
- W3156417703 cites W2127679982 @default.
- W3156417703 cites W2129962512 @default.
- W3156417703 cites W2139013177 @default.
- W3156417703 cites W2140159910 @default.
- W3156417703 cites W2142854066 @default.
- W3156417703 cites W2147863922 @default.
- W3156417703 cites W2162934389 @default.
- W3156417703 cites W2316944130 @default.
- W3156417703 cites W2320579993 @default.
- W3156417703 cites W2324837494 @default.
- W3156417703 cites W2411719773 @default.
- W3156417703 cites W2418903209 @default.
- W3156417703 cites W2517358154 @default.
- W3156417703 cites W2583012620 @default.
- W3156417703 cites W2600519085 @default.
- W3156417703 cites W2609734392 @default.
- W3156417703 cites W2746291128 @default.
- W3156417703 cites W2760958076 @default.
- W3156417703 cites W2766776412 @default.
- W3156417703 cites W2767502010 @default.
- W3156417703 cites W2808013179 @default.
- W3156417703 cites W2910712311 @default.
- W3156417703 cites W2912666348 @default.
- W3156417703 cites W2914795696 @default.
- W3156417703 cites W2920463700 @default.
- W3156417703 cites W2951503596 @default.
- W3156417703 cites W2957709421 @default.
- W3156417703 cites W2957865698 @default.
- W3156417703 cites W3011963154 @default.
- W3156417703 cites W3016710909 @default.
- W3156417703 doi "https://doi.org/10.1523/jneurosci.3086-20.2021" @default.
- W3156417703 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8211550" @default.
- W3156417703 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33879537" @default.
- W3156417703 hasPublicationYear "2021" @default.
- W3156417703 type Work @default.
- W3156417703 sameAs 3156417703 @default.
- W3156417703 citedByCount "8" @default.
- W3156417703 countsByYear W31564177032022 @default.
- W3156417703 countsByYear W31564177032023 @default.
- W3156417703 crossrefType "journal-article" @default.
- W3156417703 hasAuthorship W3156417703A5002920186 @default.
- W3156417703 hasAuthorship W3156417703A5016373888 @default.
- W3156417703 hasAuthorship W3156417703A5043082699 @default.
- W3156417703 hasAuthorship W3156417703A5049870310 @default.