FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3156464313> ?p ?o ?g. }

• W3156464313 endingPage "1268" @default.
• W3156464313 startingPage "1258" @default.
• W3156464313 abstract "Constipation and opioid-induced constipation (OIC) are common with limited treatment options. We investigated whether a noninvasive method of auricular vagal nerve stimulation (aVNS) could be used for treating OIC and explored its potential mechanisms and neural pathways in a rodent model of OIC.Sprague-Dawley were chronically implanted with one pair of auricular electrodes for aVNS. Sixteen rats were treated with loperamide for a week while another 16 rats received bilateral vagotomy, then randomly treated with aVNS or sham-aVNS for a week. In addition, eight normal rats were implanted with a polyethylene catheter in the proximal colon for assessing whole colon transit.1) The number of fecal pellets and water content in feces increased after aVNS, compared with sham-aVNS. 2) aVNS accelerated colon transit and whole gut transit, compared with sham-aVNS. 3) In colon tissues, aVNS increased the protein expression of choline acetyltransferase, glial cell line-derived neurotrophic factor and the c-kit expression in myenteric interstitial cells of Cajal but decreased the protein expression of neural nitric oxide synthase (p < 0.05 for all, vs. sham-VNS). 4) The prokinetic effects of aVNS were abolished by both subdiaphragmatic vagotomy and atropine. 5) aVNS increased the c-fos expression in both nucleus tractus solitarius and dorsal motor nucleus of vagus, and increased vagal efferent activity (p < 0.05, vs. sham-VNS).aVNS improves OIC by enhancing colon motility and restoring enteric neural functions mediated via the central and vagal efferent pathway." @default.
• W3156464313 created "2021-04-26" @default.
• W3156464313 creator A5001344196 @default.
• W3156464313 creator A5021334306 @default.
• W3156464313 creator A5028478982 @default.
• W3156464313 creator A5037458498 @default.
• W3156464313 creator A5039567363 @default.
• W3156464313 creator A5048503739 @default.
• W3156464313 creator A5050527989 @default.
• W3156464313 creator A5065897600 @default.
• W3156464313 creator A5085089524 @default.
• W3156464313 date "2021-10-01" @default.
• W3156464313 modified "2023-10-15" @default.
• W3156464313 title "Auricular Vagal Nerve Stimulation Improves Constipation by Enhancing Colon Motility via the Central-Vagal Efferent Pathway in Opioid-Induced Constipated Rats" @default.
• W3156464313 cites W1488039885 @default.
• W3156464313 cites W1969490555 @default.
• W3156464313 cites W1981367331 @default.
• W3156464313 cites W1986313972 @default.
• W3156464313 cites W1988645239 @default.
• W3156464313 cites W1999533802 @default.
• W3156464313 cites W2007133173 @default.
• W3156464313 cites W2010559206 @default.
• W3156464313 cites W2026732079 @default.
• W3156464313 cites W2041055188 @default.
• W3156464313 cites W2041581988 @default.
• W3156464313 cites W2042302510 @default.
• W3156464313 cites W2055942912 @default.
• W3156464313 cites W2069435922 @default.
• W3156464313 cites W2081430727 @default.
• W3156464313 cites W2083532103 @default.
• W3156464313 cites W2088196839 @default.
• W3156464313 cites W2093685229 @default.
• W3156464313 cites W2097431774 @default.
• W3156464313 cites W2103154281 @default.
• W3156464313 cites W2105966193 @default.
• W3156464313 cites W2111772099 @default.
• W3156464313 cites W2128669931 @default.
• W3156464313 cites W2129385409 @default.
• W3156464313 cites W2134446834 @default.
• W3156464313 cites W2147219410 @default.
• W3156464313 cites W2172158384 @default.
• W3156464313 cites W2330034445 @default.
• W3156464313 cites W2411572788 @default.
• W3156464313 cites W2412096695 @default.
• W3156464313 cites W2545799589 @default.
• W3156464313 cites W2593505727 @default.
• W3156464313 cites W2598789448 @default.
• W3156464313 cites W2602581896 @default.
• W3156464313 cites W2606592448 @default.
• W3156464313 cites W2607190565 @default.
• W3156464313 cites W2607381715 @default.
• W3156464313 cites W2749855252 @default.
• W3156464313 cites W2751280009 @default.
• W3156464313 cites W2763448688 @default.
• W3156464313 cites W2766340126 @default.
• W3156464313 cites W2769449739 @default.
• W3156464313 cites W2782377769 @default.
• W3156464313 cites W2786188339 @default.
• W3156464313 cites W2791709928 @default.
• W3156464313 cites W2888592923 @default.
• W3156464313 cites W2890470934 @default.
• W3156464313 cites W2894230569 @default.
• W3156464313 cites W2899463607 @default.
• W3156464313 cites W2900111473 @default.
• W3156464313 cites W2914479260 @default.
• W3156464313 cites W2920300099 @default.
• W3156464313 cites W2931017645 @default.
• W3156464313 cites W2944563022 @default.
• W3156464313 cites W2950407573 @default.
• W3156464313 cites W2968352727 @default.
• W3156464313 cites W3003771830 @default.
• W3156464313 cites W3008339347 @default.
• W3156464313 cites W3012319557 @default.
• W3156464313 cites W3013487665 @default.
• W3156464313 cites W3017079082 @default.
• W3156464313 cites W3045608606 @default.
• W3156464313 cites W4210981417 @default.
• W3156464313 doi "https://doi.org/10.1111/ner.13406" @default.
• W3156464313 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33887080" @default.
• W3156464313 hasPublicationYear "2021" @default.
• W3156464313 type Work @default.
• W3156464313 sameAs 3156464313 @default.
• W3156464313 citedByCount "7" @default.
• W3156464313 countsByYear W31564643132021 @default.
• W3156464313 countsByYear W31564643132022 @default.
• W3156464313 countsByYear W31564643132023 @default.
• W3156464313 crossrefType "journal-article" @default.
• W3156464313 hasAuthorship W3156464313A5001344196 @default.
• W3156464313 hasAuthorship W3156464313A5021334306 @default.
• W3156464313 hasAuthorship W3156464313A5028478982 @default.
• W3156464313 hasAuthorship W3156464313A5037458498 @default.
• W3156464313 hasAuthorship W3156464313A5039567363 @default.
• W3156464313 hasAuthorship W3156464313A5048503739 @default.
• W3156464313 hasAuthorship W3156464313A5050527989 @default.
• W3156464313 hasAuthorship W3156464313A5065897600 @default.
• W3156464313 hasAuthorship W3156464313A5085089524 @default.
• W3156464313 hasConcept C126322002 @default.
• W3156464313 hasConcept C134018914 @default.

• next