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- W3156572174 endingPage "2006" @default.
- W3156572174 startingPage "2006" @default.
- W3156572174 abstract "Recent advancements in tissue engineering and material science have radically improved in vitro culturing platforms to more accurately replicate human tissue. However, the transition to clinical relevance has been slow in part due to the lack of biologically compatible/relevant materials. In the present study, we marry the commonly used two-dimensional (2D) technique of electrospinning and a self-assembly process to construct easily reproducible, highly porous, three-dimensional (3D) nanofiber scaffolds for various tissue engineering applications. Specimens from biologically relevant polymers polycaprolactone (PCL) and gelatin were chemically cross-linked using the naturally occurring cross-linker genipin. Potential cytotoxic effects of the scaffolds were analyzed by culturing human dermal fibroblasts (HDF) up to 23 days. The 3D PCL/gelatin/genipin scaffolds produced here resemble the complex nanofibrous architecture found in naturally occurring extracellular matrix (ECM) and exhibit physiologically relevant mechanical properties as well as excellent cell cytocompatibility. Samples cross-linked with 0.5% genipin demonstrated the highest metabolic activity and proliferation rates for HDF. Scanning electron microscopy (SEM) images indicated excellent cell adhesion and the characteristic morphological features of fibroblasts in all tested samples. The three-dimensional (3D) PCL/gelatin/genipin scaffolds produced here show great potential for various 3D tissue-engineering applications such as ex vivo cell culturing platforms, wound healing, or tissue replacement." @default.
- W3156572174 created "2021-04-26" @default.
- W3156572174 creator A5037018090 @default.
- W3156572174 creator A5056720891 @default.
- W3156572174 creator A5078556339 @default.
- W3156572174 date "2021-04-16" @default.
- W3156572174 modified "2023-10-02" @default.
- W3156572174 title "3D PCL/Gelatin/Genipin Nanofiber Sponge as Scaffold for Regenerative Medicine" @default.
- W3156572174 cites W1506424806 @default.
- W3156572174 cites W1536937650 @default.
- W3156572174 cites W1862989971 @default.
- W3156572174 cites W1966565238 @default.
- W3156572174 cites W1968336848 @default.
- W3156572174 cites W1984417662 @default.
- W3156572174 cites W1991158714 @default.
- W3156572174 cites W1997122870 @default.
- W3156572174 cites W1997847274 @default.
- W3156572174 cites W2008850772 @default.
- W3156572174 cites W2013711330 @default.
- W3156572174 cites W2020983389 @default.
- W3156572174 cites W2022936165 @default.
- W3156572174 cites W2023166500 @default.
- W3156572174 cites W2029702180 @default.
- W3156572174 cites W2038634187 @default.
- W3156572174 cites W2038705284 @default.
- W3156572174 cites W2038846258 @default.
- W3156572174 cites W2039397503 @default.
- W3156572174 cites W2040588591 @default.
- W3156572174 cites W2041465820 @default.
- W3156572174 cites W2041662588 @default.
- W3156572174 cites W2042864468 @default.
- W3156572174 cites W2046774273 @default.
- W3156572174 cites W2052651662 @default.
- W3156572174 cites W2054992640 @default.
- W3156572174 cites W2055696984 @default.
- W3156572174 cites W2061142495 @default.
- W3156572174 cites W2066620625 @default.
- W3156572174 cites W2069579154 @default.
- W3156572174 cites W2069984736 @default.
- W3156572174 cites W2070636326 @default.
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- W3156572174 cites W2076174682 @default.
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- W3156572174 cites W2087436263 @default.
- W3156572174 cites W2091950800 @default.
- W3156572174 cites W2092213016 @default.
- W3156572174 cites W2098185891 @default.
- W3156572174 cites W2101601223 @default.
- W3156572174 cites W2103883318 @default.
- W3156572174 cites W2113241079 @default.
- W3156572174 cites W2121045985 @default.
- W3156572174 cites W2124713669 @default.
- W3156572174 cites W2125364971 @default.
- W3156572174 cites W2128673130 @default.
- W3156572174 cites W2128839536 @default.
- W3156572174 cites W2133210431 @default.
- W3156572174 cites W2140960447 @default.
- W3156572174 cites W2150311904 @default.
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- W3156572174 cites W2167243609 @default.
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- W3156572174 cites W2272323856 @default.
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- W3156572174 cites W2395829607 @default.
- W3156572174 cites W2509043347 @default.
- W3156572174 cites W2531646759 @default.
- W3156572174 cites W2549169970 @default.
- W3156572174 cites W2550513299 @default.
- W3156572174 cites W2609793327 @default.
- W3156572174 cites W2609900592 @default.
- W3156572174 cites W2717381632 @default.
- W3156572174 cites W2789911988 @default.
- W3156572174 cites W2790597025 @default.
- W3156572174 cites W2791511098 @default.
- W3156572174 cites W2890132492 @default.
- W3156572174 cites W2891971827 @default.
- W3156572174 cites W2904979218 @default.
- W3156572174 cites W2921132637 @default.
- W3156572174 cites W2953678388 @default.
- W3156572174 cites W2985369743 @default.
- W3156572174 cites W2995139622 @default.
- W3156572174 cites W3008162098 @default.
- W3156572174 cites W3011914416 @default.
- W3156572174 cites W3048689440 @default.
- W3156572174 cites W3083055781 @default.
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- W3156572174 cites W3093352269 @default.
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- W3156572174 doi "https://doi.org/10.3390/ma14082006" @default.
- W3156572174 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8072632" @default.
- W3156572174 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33923751" @default.
- W3156572174 hasPublicationYear "2021" @default.
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