FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3156603251> ?p ?o ?g. }

• W3156603251 endingPage "110331" @default.
• W3156603251 startingPage "110331" @default.
• W3156603251 abstract "Over sixteen million people suffer from a depressive episode annually in the United States, with females affected at twice the rate of males. Little is known about the effects of exposure to high altitude on the risk of development of major depressive disorder, despite reports of higher suicide rates at higher altitudes. We hypothesize that exposure to hypobaric hypoxia at high altitude increases endophenotypes of self-directed suicidal violence, including biological signatures of chronic inflammation and vulnerability to anxiety-like and depressive-like behavioral responses in a sex-specific manner. Biological signatures of inflammation, including granulocyte:lymphocyte ratios, monocyte cell counts, and monocyte:lymphocyte ratios were assessed using complete blood count data, anhedonia, and anxiety- and depressive-like behavioral responses were evaluated. We assessed biological signatures of inflammation and behavioral responses in the open-field test, sucrose preference test, and modified Porsolt forced swim test in young adult male and female Long-Evans and Sprague Dawley rats. All tests were conducted near sea level (374 ft [114 m] elevation) and at moderate-high altitude (5430 ft [1655 m] elevation) during acclimation periods of one, two, three, four, and five weeks following shipment from a sea level animal breeding facility (N = 320, n = 8 per group). Exposure to moderate-high altitude induced a biological signature of increased inflammation, as evidenced by main effects of altitude for: 1) increased granulocyte:lymphocyte ratio; 2) increased count and relative abundance of circulating monocytes; and 3) increased monocyte:lymphocyte ratios. Exposure to moderate-high altitude also increased anhedonia as assessed in the sucrose preference test in both male and female rats, when data were collapsed across strain and time. Among male and female Long Evans rats, exposure to moderate-high altitude increased immobility in the forced swim test, without changing anxiety-like behaviors in the open-field test. Finally, granulocyte:lymphocyte ratios were correlated with anhedonia in the sucrose preference test. These data are consistent with the hypothesis that hypobaric hypoxia at moderate-high altitude induces persistent endophenotypes of self-directed suicidal violence including biological signatures of inflammation, anhedonia, and depressive-like behavioral responses." @default.
• W3156603251 created "2021-04-26" @default.
• W3156603251 creator A5004193255 @default.
• W3156603251 creator A5018144763 @default.
• W3156603251 creator A5020521987 @default.
• W3156603251 creator A5020963967 @default.
• W3156603251 creator A5026164041 @default.
• W3156603251 creator A5033701777 @default.
• W3156603251 creator A5036393409 @default.
• W3156603251 creator A5046990042 @default.
• W3156603251 creator A5057954261 @default.
• W3156603251 creator A5062567822 @default.
• W3156603251 creator A5065680780 @default.
• W3156603251 creator A5076241900 @default.
• W3156603251 creator A5085353227 @default.
• W3156603251 date "2021-12-01" @default.
• W3156603251 modified "2023-09-29" @default.
• W3156603251 title "Evaluation of the effects of altitude on biological signatures of inflammation and anxiety- and depressive-like behavioral responses" @default.
• W3156603251 cites W10058053 @default.
• W3156603251 cites W106742883 @default.
• W3156603251 cites W1763857274 @default.
• W3156603251 cites W1972383405 @default.
• W3156603251 cites W1974820251 @default.
• W3156603251 cites W1974957442 @default.
• W3156603251 cites W1976392245 @default.
• W3156603251 cites W1977740141 @default.
• W3156603251 cites W1978239142 @default.
• W3156603251 cites W1990751002 @default.
• W3156603251 cites W1998297736 @default.
• W3156603251 cites W2005615586 @default.
• W3156603251 cites W2007070932 @default.
• W3156603251 cites W2008301991 @default.
• W3156603251 cites W2010526028 @default.
• W3156603251 cites W2011943131 @default.
• W3156603251 cites W2012106120 @default.
• W3156603251 cites W2017085818 @default.
• W3156603251 cites W2030260413 @default.
• W3156603251 cites W2030554335 @default.
• W3156603251 cites W2032913982 @default.
• W3156603251 cites W2038083677 @default.
• W3156603251 cites W2039408242 @default.
• W3156603251 cites W2051586504 @default.
• W3156603251 cites W2051719689 @default.
• W3156603251 cites W2051739922 @default.
• W3156603251 cites W2055562549 @default.
• W3156603251 cites W2056728390 @default.
• W3156603251 cites W2058189072 @default.
• W3156603251 cites W2059979222 @default.
• W3156603251 cites W2062728786 @default.
• W3156603251 cites W2067814202 @default.
• W3156603251 cites W2072666958 @default.
• W3156603251 cites W2074801302 @default.
• W3156603251 cites W2084368765 @default.
• W3156603251 cites W2091064555 @default.
• W3156603251 cites W2096022216 @default.
• W3156603251 cites W2097740790 @default.
• W3156603251 cites W2101522641 @default.
• W3156603251 cites W2116553160 @default.
• W3156603251 cites W2116889297 @default.
• W3156603251 cites W2127061615 @default.
• W3156603251 cites W2150628872 @default.
• W3156603251 cites W2152309548 @default.
• W3156603251 cites W2153062324 @default.
• W3156603251 cites W2163364464 @default.
• W3156603251 cites W2180588657 @default.
• W3156603251 cites W2201607793 @default.
• W3156603251 cites W2222212830 @default.
• W3156603251 cites W2258719822 @default.
• W3156603251 cites W2337946648 @default.
• W3156603251 cites W2517170026 @default.
• W3156603251 cites W2588121597 @default.
• W3156603251 cites W2606077861 @default.
• W3156603251 cites W2627070208 @default.
• W3156603251 cites W2742915870 @default.
• W3156603251 cites W2762869920 @default.
• W3156603251 cites W2770318346 @default.
• W3156603251 cites W2782494815 @default.
• W3156603251 cites W2792366526 @default.
• W3156603251 cites W2801439079 @default.
• W3156603251 cites W2809988486 @default.
• W3156603251 cites W2884038574 @default.
• W3156603251 cites W2892039749 @default.
• W3156603251 cites W2901278333 @default.
• W3156603251 cites W2910003107 @default.
• W3156603251 cites W2945901381 @default.
• W3156603251 cites W2953366830 @default.
• W3156603251 cites W2962480942 @default.
• W3156603251 cites W2971644525 @default.
• W3156603251 cites W2989074685 @default.
• W3156603251 cites W2991010196 @default.
• W3156603251 cites W2999914623 @default.
• W3156603251 cites W3008274162 @default.
• W3156603251 cites W3014607402 @default.
• W3156603251 cites W3028774941 @default.
• W3156603251 cites W3080862223 @default.
• W3156603251 cites W611702295 @default.
• W3156603251 doi "https://doi.org/10.1016/j.pnpbp.2021.110331" @default.
• W3156603251 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33891978" @default.

• next