FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3156611312> ?p ?o ?g. }

• W3156611312 endingPage "624" @default.
• W3156611312 startingPage "612" @default.
• W3156611312 abstract "Noncanonical Wnt5a is a particularly attractive growth factor to maintain chondrogenesis. Platelet-rich plasma (PRP) is an autologous blood-derived product and a source of bioactive growth factors involved in tissue regeneration. The present study aimed to investigate the effect and inflammation reaction of Wnt5a/PRP on meniscus cells, and evaluate meniscus regeneration and osteoarthritis (OA) prevention by the application of Wnt5a/PRP gel in a rabbit model of massive meniscal defect. In vitro, the proliferation, migration, differentiation, and interleukin-1 beta (IL-1β) IL-1β-induced inflammation reaction of meniscus cells treated by Wnt5a and PRP was assessed. In vivo, the anterior half of the medial meniscus of 18 New Zealand rabbits was excised and implanted with PRP gel, Wnt5a/PRP gel or untreated. After 6 and 12 weeks, the regenerated meniscus were evaluated. Wnt5a can promote the migration of meniscus cells. PRP and Wnt5a had synergistic effect in promoting the proliferation and chondrogenic differentiation of meniscus cells. The IL-1β-induced meniscus cells study showed that PRP and Wnt5a had the anti-inflammatory actions through nuclear factor kB (NF-κB) signaling pathway. PRP and Wnt5a/PRP significantly inhibited the increase of the p-p65/p65 and p-IκB-α/IκB-α ratios. In vivo transplantation of Wnt5a/PRP gel was demonstrated to promote meniscus regeneration, while reducing OA of knee joint. Wnt5a with PRP had the anti-inflammatory activity in an IL-1β-induced inflammatory model. They can synergistically improve the chondorgenic differentiation of meniscus cells. Wnt5a/PRP gel treatment could potentially be developed into a new method for meniscus regeneration and the prevention of OA." @default.
• W3156611312 created "2021-04-26" @default.
• W3156611312 creator A5044435720 @default.
• W3156611312 creator A5062096045 @default.
• W3156611312 creator A5066208937 @default.
• W3156611312 creator A5072825795 @default.
• W3156611312 creator A5086670659 @default.
• W3156611312 date "2021-04-19" @default.
• W3156611312 modified "2023-10-18" @default.
• W3156611312 title "Wnt5a/Platelet‐rich plasma synergistically inhibits IL‐1β‐induced inflammatory activity through NF‐κB signaling pathway and prevents cartilage damage and promotes meniscus regeneration" @default.
• W3156611312 cites W1873023416 @default.
• W3156611312 cites W1946356995 @default.
• W3156611312 cites W1946911025 @default.
• W3156611312 cites W1947391889 @default.
• W3156611312 cites W1966585960 @default.
• W3156611312 cites W1997844772 @default.
• W3156611312 cites W2000063386 @default.
• W3156611312 cites W2006050540 @default.
• W3156611312 cites W2009313114 @default.
• W3156611312 cites W2010551744 @default.
• W3156611312 cites W2020020571 @default.
• W3156611312 cites W2035765664 @default.
• W3156611312 cites W2036305631 @default.
• W3156611312 cites W2037080051 @default.
• W3156611312 cites W2037328562 @default.
• W3156611312 cites W2043498326 @default.
• W3156611312 cites W2044545243 @default.
• W3156611312 cites W2062744404 @default.
• W3156611312 cites W2067870418 @default.
• W3156611312 cites W2074716378 @default.
• W3156611312 cites W2078498321 @default.
• W3156611312 cites W2082508224 @default.
• W3156611312 cites W2099427592 @default.
• W3156611312 cites W2099531851 @default.
• W3156611312 cites W2128181658 @default.
• W3156611312 cites W2132884161 @default.
• W3156611312 cites W2155663618 @default.
• W3156611312 cites W2164434561 @default.
• W3156611312 cites W2168702740 @default.
• W3156611312 cites W2171201550 @default.
• W3156611312 cites W2279928918 @default.
• W3156611312 cites W2343734780 @default.
• W3156611312 cites W2346491356 @default.
• W3156611312 cites W2498297759 @default.
• W3156611312 cites W2587801355 @default.
• W3156611312 cites W2605690794 @default.
• W3156611312 cites W2625100235 @default.
• W3156611312 cites W2776452414 @default.
• W3156611312 cites W2797869734 @default.
• W3156611312 cites W2832854185 @default.
• W3156611312 cites W2952697263 @default.
• W3156611312 cites W2956109059 @default.
• W3156611312 cites W3039269073 @default.
• W3156611312 cites W4230248133 @default.
• W3156611312 cites W4292542165 @default.
• W3156611312 doi "https://doi.org/10.1002/term.3198" @default.
• W3156611312 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33843153" @default.
• W3156611312 hasPublicationYear "2021" @default.
• W3156611312 type Work @default.
• W3156611312 sameAs 3156611312 @default.
• W3156611312 citedByCount "12" @default.
• W3156611312 countsByYear W31566113122021 @default.
• W3156611312 countsByYear W31566113122022 @default.
• W3156611312 countsByYear W31566113122023 @default.
• W3156611312 crossrefType "journal-article" @default.
• W3156611312 hasAuthorship W3156611312A5044435720 @default.
• W3156611312 hasAuthorship W3156611312A5062096045 @default.
• W3156611312 hasAuthorship W3156611312A5066208937 @default.
• W3156611312 hasAuthorship W3156611312A5072825795 @default.
• W3156611312 hasAuthorship W3156611312A5086670659 @default.
• W3156611312 hasBestOaLocation W31566113121 @default.
• W3156611312 hasConcept C105702510 @default.
• W3156611312 hasConcept C120665830 @default.
• W3156611312 hasConcept C121332964 @default.
• W3156611312 hasConcept C137620995 @default.
• W3156611312 hasConcept C171056886 @default.
• W3156611312 hasConcept C185592680 @default.
• W3156611312 hasConcept C189178095 @default.
• W3156611312 hasConcept C203014093 @default.
• W3156611312 hasConcept C2776914184 @default.
• W3156611312 hasConcept C2780076745 @default.
• W3156611312 hasConcept C2780176071 @default.
• W3156611312 hasConcept C2780550940 @default.
• W3156611312 hasConcept C35496256 @default.
• W3156611312 hasConcept C61511704 @default.
• W3156611312 hasConcept C62478195 @default.
• W3156611312 hasConcept C71924100 @default.
• W3156611312 hasConcept C86803240 @default.
• W3156611312 hasConcept C89560881 @default.
• W3156611312 hasConcept C95444343 @default.
• W3156611312 hasConceptScore W3156611312C105702510 @default.
• W3156611312 hasConceptScore W3156611312C120665830 @default.
• W3156611312 hasConceptScore W3156611312C121332964 @default.
• W3156611312 hasConceptScore W3156611312C137620995 @default.
• W3156611312 hasConceptScore W3156611312C171056886 @default.
• W3156611312 hasConceptScore W3156611312C185592680 @default.
• W3156611312 hasConceptScore W3156611312C189178095 @default.
• W3156611312 hasConceptScore W3156611312C203014093 @default.

• next