Matches in SemOpenAlex for { <https://semopenalex.org/work/W3156668015> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W3156668015 abstract "Abstract Introduction Oesophagectomy is being increasingly performed in an ageing population that is observing a concomitant growth in the life expectancy. However, the risks are poorly quantified, and this study aims to review current evidence to further quantify the postoperative of oesophagectomy in the elderly population compared to younger patients. Methods A systematic electronic search was conducted for studies reporting oesophagectomy in the elderly population. Meta-analysis was performed using random-effects modelling to compute odds ratios (OR) and 95% confidence intervals (CI). Primary outcome was overall complications and secondary outcomes included anastomotic leaks, cardiac complications, pulmonary complications, overall and disease-free survival. Meta-regression was performed to identify study-, hospital- and patient-level factors confounding study findings. Results This review included 37 eligible studies involving 61,723 patients. Increasing age was significantly associated with increased rates of overall complications (OR: 1.67, CI 95%: 1.42 – 1.97), cardiac complications (OR: 1.62, CI 95%: 1.10 – 2.40), pulmonary complications (OR: 1.44, CI 95%: 1.11 – 1.87) and decreased 5-year overall survival (OR: 1.36, CI 95%: 1.11 – 1.66) and 5-year disease-free survival (OR: 1.66, CI 95%: 1.40 – 1.97). Rates of anastomotic leaks showed no difference between elderly and younger patients (OR: 1.06, CI 95%: 0.71 – 1.59). Conclusion Postoperative outcomes such as overall complications, 5-year overall survival and disease-free survival appear to significantly worse in all age cut-offs in this meta-analysis. Sarcopenia and frailty act as better predictors of postoperative outcomes than chronological age. This study confirms the preconceived suspicions of increased risks in elderly patients following oesophagectomy and will aid future pre-operative counselling and informed consent." @default.
- W3156668015 created "2021-04-26" @default.
- W3156668015 creator A5019563180 @default.
- W3156668015 creator A5028243856 @default.
- W3156668015 creator A5041903193 @default.
- W3156668015 creator A5046798649 @default.
- W3156668015 creator A5046988847 @default.
- W3156668015 creator A5058123894 @default.
- W3156668015 creator A5080469241 @default.
- W3156668015 date "2021-04-01" @default.
- W3156668015 modified "2023-10-16" @default.
- W3156668015 title "P22 Are Elderly Patients at Increased Perioperative Morbidity and Mortality from Oesophagectomy for Oesophageal Cancer? A Systematic Mapping Review and Meta-Analysis" @default.
- W3156668015 doi "https://doi.org/10.1093/bjsopen/zrab032.021" @default.
- W3156668015 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8153818" @default.
- W3156668015 hasPublicationYear "2021" @default.
- W3156668015 type Work @default.
- W3156668015 sameAs 3156668015 @default.
- W3156668015 citedByCount "0" @default.
- W3156668015 crossrefType "journal-article" @default.
- W3156668015 hasAuthorship W3156668015A5019563180 @default.
- W3156668015 hasAuthorship W3156668015A5028243856 @default.
- W3156668015 hasAuthorship W3156668015A5041903193 @default.
- W3156668015 hasAuthorship W3156668015A5046798649 @default.
- W3156668015 hasAuthorship W3156668015A5046988847 @default.
- W3156668015 hasAuthorship W3156668015A5058123894 @default.
- W3156668015 hasAuthorship W3156668015A5080469241 @default.
- W3156668015 hasBestOaLocation W31566680151 @default.
- W3156668015 hasConcept C121608353 @default.
- W3156668015 hasConcept C126322002 @default.
- W3156668015 hasConcept C141071460 @default.
- W3156668015 hasConcept C156957248 @default.
- W3156668015 hasConcept C2776214593 @default.
- W3156668015 hasConcept C2777297899 @default.
- W3156668015 hasConcept C2779384505 @default.
- W3156668015 hasConcept C2779742542 @default.
- W3156668015 hasConcept C2908647359 @default.
- W3156668015 hasConcept C31174226 @default.
- W3156668015 hasConcept C44249647 @default.
- W3156668015 hasConcept C71924100 @default.
- W3156668015 hasConcept C77350462 @default.
- W3156668015 hasConcept C95190672 @default.
- W3156668015 hasConcept C99454951 @default.
- W3156668015 hasConceptScore W3156668015C121608353 @default.
- W3156668015 hasConceptScore W3156668015C126322002 @default.
- W3156668015 hasConceptScore W3156668015C141071460 @default.
- W3156668015 hasConceptScore W3156668015C156957248 @default.
- W3156668015 hasConceptScore W3156668015C2776214593 @default.
- W3156668015 hasConceptScore W3156668015C2777297899 @default.
- W3156668015 hasConceptScore W3156668015C2779384505 @default.
- W3156668015 hasConceptScore W3156668015C2779742542 @default.
- W3156668015 hasConceptScore W3156668015C2908647359 @default.
- W3156668015 hasConceptScore W3156668015C31174226 @default.
- W3156668015 hasConceptScore W3156668015C44249647 @default.
- W3156668015 hasConceptScore W3156668015C71924100 @default.
- W3156668015 hasConceptScore W3156668015C77350462 @default.
- W3156668015 hasConceptScore W3156668015C95190672 @default.
- W3156668015 hasConceptScore W3156668015C99454951 @default.
- W3156668015 hasIssue "Supplement_1" @default.
- W3156668015 hasLocation W31566680151 @default.
- W3156668015 hasLocation W31566680152 @default.
- W3156668015 hasOpenAccess W3156668015 @default.
- W3156668015 hasPrimaryLocation W31566680151 @default.
- W3156668015 hasRelatedWork W125632434 @default.
- W3156668015 hasRelatedWork W1984235851 @default.
- W3156668015 hasRelatedWork W1985716775 @default.
- W3156668015 hasRelatedWork W2093208418 @default.
- W3156668015 hasRelatedWork W2292047642 @default.
- W3156668015 hasRelatedWork W2801842873 @default.
- W3156668015 hasRelatedWork W2990457081 @default.
- W3156668015 hasRelatedWork W3028913152 @default.
- W3156668015 hasRelatedWork W4283161852 @default.
- W3156668015 hasRelatedWork W4293824699 @default.
- W3156668015 hasVolume "5" @default.
- W3156668015 isParatext "false" @default.
- W3156668015 isRetracted "false" @default.
- W3156668015 magId "3156668015" @default.
- W3156668015 workType "article" @default.