Matches in SemOpenAlex for { <https://semopenalex.org/work/W3156684804> ?p ?o ?g. }
- W3156684804 endingPage "1086" @default.
- W3156684804 startingPage "1086" @default.
- W3156684804 abstract "Ciprofloxacin (CIP), a potent anti-bacterial agent of the fluroquinolone family, shows poor solubility and permeability, thus leading to the development of intracellular pathogens induced multi-drug resistance and biofilms formation. To synergistically improve the biopharmaceutical parameters of CIP, a hyaluronic acid (FDA approved biocompatible polymer) functionalized self-nano emulsifying drug delivery system (HA-CIP-SNEDDS) was designed in the present study. SNEDDS formulations were tested via solubility, droplet size, zeta potential, a polydispersity index, thermodynamic stability, surface morphology, solid-state characterization, drug loading/release, cellular uptake, and biocompatibility. The final (HA-CIP-SNEDDS) formulation exhibited a mean droplet size of 50 nm with the 0.3 poly dispersity index and negative zeta potential (−11.4 mV). HA-based SNEDDS containing CIP showed an improved ability to permeate goat intestinal mucus. After 4 h, CIP-SNEDDS showed a 2-fold and HA-CIP-SNEDDS showed a 4-fold permeation enhancement as compared to the free CIP. Moreover, 80% drug release of HA-CIP-SNEDDS was demonstrated to be superior and sustained for 72 h in comparison to free CIP. However, anti-biofilm activity of HA-CIP-SNEDDS against Salmonella typhi was higher than CIP-SNEDDS and free CIP. HA-CIP-SNEDDS exhibited increased biocompatibility and improved oral pharmacokinetics as compared to free CIP. Taken together, HA-CIP-SNEDDS formulation seems to be a promising agent against Salmonella typhi with a strong targeting potential." @default.
- W3156684804 created "2021-04-26" @default.
- W3156684804 creator A5008829126 @default.
- W3156684804 creator A5021563262 @default.
- W3156684804 creator A5029753585 @default.
- W3156684804 creator A5030966726 @default.
- W3156684804 creator A5038945855 @default.
- W3156684804 creator A5044699104 @default.
- W3156684804 creator A5051243769 @default.
- W3156684804 creator A5052911889 @default.
- W3156684804 date "2021-04-22" @default.
- W3156684804 modified "2023-10-14" @default.
- W3156684804 title "A Hyaluronic Acid Functionalized Self-Nano-Emulsifying Drug Delivery System (SNEDDS) for Enhancement in Ciprofloxacin Targeted Delivery against Intracellular Infection" @default.
- W3156684804 cites W2027741236 @default.
- W3156684804 cites W2567872759 @default.
- W3156684804 cites W2577974912 @default.
- W3156684804 cites W2593691236 @default.
- W3156684804 cites W2752670805 @default.
- W3156684804 cites W2782288498 @default.
- W3156684804 cites W2790092507 @default.
- W3156684804 cites W2888286625 @default.
- W3156684804 cites W2891129265 @default.
- W3156684804 cites W2894069580 @default.
- W3156684804 cites W2915978566 @default.
- W3156684804 cites W2922428194 @default.
- W3156684804 cites W2925338650 @default.
- W3156684804 cites W2937188942 @default.
- W3156684804 cites W2937415326 @default.
- W3156684804 cites W2946602970 @default.
- W3156684804 cites W2948725621 @default.
- W3156684804 cites W2950790549 @default.
- W3156684804 cites W2967691925 @default.
- W3156684804 cites W2981047250 @default.
- W3156684804 cites W2987648706 @default.
- W3156684804 cites W2996167506 @default.
- W3156684804 cites W2997073647 @default.
- W3156684804 cites W2999717410 @default.
- W3156684804 cites W3000708170 @default.
- W3156684804 cites W3003542030 @default.
- W3156684804 cites W3007601922 @default.
- W3156684804 cites W3007924994 @default.
- W3156684804 cites W3009631698 @default.
- W3156684804 cites W3015921453 @default.
- W3156684804 cites W3016252726 @default.
- W3156684804 cites W3025686535 @default.
- W3156684804 cites W3032991000 @default.
- W3156684804 cites W3040063260 @default.
- W3156684804 cites W3044679984 @default.
- W3156684804 cites W3046620902 @default.
- W3156684804 cites W3061198798 @default.
- W3156684804 cites W3110467961 @default.
- W3156684804 cites W3120556384 @default.
- W3156684804 cites W4230183648 @default.
- W3156684804 doi "https://doi.org/10.3390/nano11051086" @default.
- W3156684804 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8146397" @default.
- W3156684804 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33922241" @default.
- W3156684804 hasPublicationYear "2021" @default.
- W3156684804 type Work @default.
- W3156684804 sameAs 3156684804 @default.
- W3156684804 citedByCount "40" @default.
- W3156684804 countsByYear W31566848042021 @default.
- W3156684804 countsByYear W31566848042022 @default.
- W3156684804 countsByYear W31566848042023 @default.
- W3156684804 crossrefType "journal-article" @default.
- W3156684804 hasAuthorship W3156684804A5008829126 @default.
- W3156684804 hasAuthorship W3156684804A5021563262 @default.
- W3156684804 hasAuthorship W3156684804A5029753585 @default.
- W3156684804 hasAuthorship W3156684804A5030966726 @default.
- W3156684804 hasAuthorship W3156684804A5038945855 @default.
- W3156684804 hasAuthorship W3156684804A5044699104 @default.
- W3156684804 hasAuthorship W3156684804A5051243769 @default.
- W3156684804 hasAuthorship W3156684804A5052911889 @default.
- W3156684804 hasBestOaLocation W31566848041 @default.
- W3156684804 hasConcept C11432220 @default.
- W3156684804 hasConcept C138651985 @default.
- W3156684804 hasConcept C155574463 @default.
- W3156684804 hasConcept C155672457 @default.
- W3156684804 hasConcept C171250308 @default.
- W3156684804 hasConcept C178790620 @default.
- W3156684804 hasConcept C181389837 @default.
- W3156684804 hasConcept C185592680 @default.
- W3156684804 hasConcept C192562407 @default.
- W3156684804 hasConcept C2777230088 @default.
- W3156684804 hasConcept C2778512257 @default.
- W3156684804 hasConcept C2779820397 @default.
- W3156684804 hasConcept C2909582096 @default.
- W3156684804 hasConcept C41625074 @default.
- W3156684804 hasConcept C43617362 @default.
- W3156684804 hasConcept C501593827 @default.
- W3156684804 hasConcept C50670333 @default.
- W3156684804 hasConcept C55493867 @default.
- W3156684804 hasConcept C71924100 @default.
- W3156684804 hasConcept C86181022 @default.
- W3156684804 hasConcept C98274493 @default.
- W3156684804 hasConceptScore W3156684804C11432220 @default.
- W3156684804 hasConceptScore W3156684804C138651985 @default.
- W3156684804 hasConceptScore W3156684804C155574463 @default.
- W3156684804 hasConceptScore W3156684804C155672457 @default.