FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3156714435> ?p ?o ?g. }

• W3156714435 endingPage "15" @default.
• W3156714435 startingPage "1" @default.
• W3156714435 abstract "The microtubule-associated protein (MAP) TAU is mainly sorted into the axon of healthy brain neurons. Somatodendritic missorting of TAU is a pathological hallmark of many neurodegenerative diseases, including Alzheimer's disease (AD). Cause, consequence and (patho)physiological mechanisms of TAU sorting and missorting are understudied, in part also because of the lack of readily available human neuronal model systems. The human neuroblastoma cell line SH-SY5Y is widely used for studying TAU physiology and TAU-related pathology in AD and related tauopathies. SH-SY5Y cells can be differentiated into neuron-like cells (SH-SY5Y-derived neurons) using various substances. This review evaluates whether SH-SY5Y-derived neurons are a suitable model for (i) investigating intracellular TAU sorting in general, and (ii) with respect to neuron subtype-specific TAU vulnerability. (I) SH-SY5Y-derived neurons show pronounced axodendritic polarity, high levels of axonally localized TAU protein, expression of all six human brain isoforms and TAU phosphorylation similar to the human brain. As SH-SY5Y cells are highly proliferative and readily accessible for genetic engineering, stable transgene integration and leading-edge genome editing are feasible. (II) SH-SY5Y-derived neurons display features of subcortical neurons early affected in many tauopathies. This allows analyzing brain region-specific differences in TAU physiology, also in the context of differential vulnerability to TAU pathology. However, several limitations should be considered when using SH-SY5Y-derived neurons, e.g., the lack of clearly defined neuronal subtypes, or the difficulty of mimicking age-related tauopathy risk factors in vitro. In brief, this review discusses the suitability of SH-SY5Y-derived neurons for investigating TAU (mis)sorting mechanisms and neuron-specific TAU vulnerability in disease paradigms." @default.
• W3156714435 created "2021-04-26" @default.
• W3156714435 creator A5007142069 @default.
• W3156714435 creator A5087216281 @default.
• W3156714435 date "2021-04-19" @default.
• W3156714435 modified "2023-10-16" @default.
• W3156714435 title "SH-SY5Y-derived neurons: a human neuronal model system for investigating TAU sorting and neuronal subtype-specific TAU vulnerability" @default.
• W3156714435 cites W1032333588 @default.
• W3156714435 cites W1509571186 @default.
• W3156714435 cites W150987474 @default.
• W3156714435 cites W1528219518 @default.
• W3156714435 cites W1540758658 @default.
• W3156714435 cites W1544371346 @default.
• W3156714435 cites W1600934558 @default.
• W3156714435 cites W1601433695 @default.
• W3156714435 cites W1639168368 @default.
• W3156714435 cites W1878342051 @default.
• W3156714435 cites W1926421284 @default.
• W3156714435 cites W1965049154 @default.
• W3156714435 cites W1970878854 @default.
• W3156714435 cites W1971165215 @default.
• W3156714435 cites W1973256734 @default.
• W3156714435 cites W1973295647 @default.
• W3156714435 cites W1974523047 @default.
• W3156714435 cites W1975040221 @default.
• W3156714435 cites W1978278560 @default.
• W3156714435 cites W1978324040 @default.
• W3156714435 cites W1980225806 @default.
• W3156714435 cites W1980806973 @default.
• W3156714435 cites W1984543012 @default.
• W3156714435 cites W1986423695 @default.
• W3156714435 cites W1988993069 @default.
• W3156714435 cites W1992604829 @default.
• W3156714435 cites W1993888368 @default.
• W3156714435 cites W1994030229 @default.
• W3156714435 cites W1994234870 @default.
• W3156714435 cites W1995562130 @default.
• W3156714435 cites W2001253835 @default.
• W3156714435 cites W2001319102 @default.
• W3156714435 cites W2004901932 @default.
• W3156714435 cites W2005740454 @default.
• W3156714435 cites W2005795346 @default.
• W3156714435 cites W2009148175 @default.
• W3156714435 cites W2010120109 @default.
• W3156714435 cites W2011634611 @default.
• W3156714435 cites W2015033799 @default.
• W3156714435 cites W2015429211 @default.
• W3156714435 cites W2016104434 @default.
• W3156714435 cites W2016204025 @default.
• W3156714435 cites W2017150899 @default.
• W3156714435 cites W2017838336 @default.
• W3156714435 cites W2018908557 @default.
• W3156714435 cites W2021590064 @default.
• W3156714435 cites W2025693096 @default.
• W3156714435 cites W2026534317 @default.
• W3156714435 cites W2026541424 @default.
• W3156714435 cites W2028410287 @default.
• W3156714435 cites W2033037904 @default.
• W3156714435 cites W2033375031 @default.
• W3156714435 cites W2033544342 @default.
• W3156714435 cites W2033673027 @default.
• W3156714435 cites W2033722958 @default.
• W3156714435 cites W2034706078 @default.
• W3156714435 cites W2035282018 @default.
• W3156714435 cites W2037845048 @default.
• W3156714435 cites W2039468514 @default.
• W3156714435 cites W2040426212 @default.
• W3156714435 cites W2041390299 @default.
• W3156714435 cites W2042458678 @default.
• W3156714435 cites W2043474542 @default.
• W3156714435 cites W2044098590 @default.
• W3156714435 cites W2044908785 @default.
• W3156714435 cites W2046573564 @default.
• W3156714435 cites W2046622154 @default.
• W3156714435 cites W2047477486 @default.
• W3156714435 cites W2050665230 @default.
• W3156714435 cites W2051385566 @default.
• W3156714435 cites W2052742260 @default.
• W3156714435 cites W2057160717 @default.
• W3156714435 cites W2062161179 @default.
• W3156714435 cites W2062715442 @default.
• W3156714435 cites W2064841852 @default.
• W3156714435 cites W2065070899 @default.
• W3156714435 cites W2067879747 @default.
• W3156714435 cites W2068385989 @default.
• W3156714435 cites W2071397750 @default.
• W3156714435 cites W2071972588 @default.
• W3156714435 cites W2074144338 @default.
• W3156714435 cites W2075180535 @default.
• W3156714435 cites W2078407291 @default.
• W3156714435 cites W2081164888 @default.
• W3156714435 cites W2081533023 @default.
• W3156714435 cites W2089425170 @default.
• W3156714435 cites W2090302692 @default.
• W3156714435 cites W2093271285 @default.
• W3156714435 cites W2095368415 @default.
• W3156714435 cites W2103135451 @default.
• W3156714435 cites W2104227586 @default.

• next