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- W3156808538 endingPage "105044" @default.
- W3156808538 startingPage "105044" @default.
- W3156808538 abstract "Posttraumatic stress disorder (PTSD) is a devastating medical illness, for which currently available pharmacotherapies have poor efficacy. Accumulating evidence from clinical and preclinical animal investigations supports that ketamine exhibits a rapid and persistent effect against PTSD, though the underlying molecular mechanism remains to be clarified. In this literature review, we recapitulate the achievements from early ketamine studies to the most up-to-date discoveries, with an effort to discuss an inclusive therapeutic role of ketamine for PTSD treatment and its possible therapeutic mechanism. Ketamine seems to have an inimitable mechanism of action entailing glutamate modulation via actions at the N-methyl-D-aspartate (NMDA) and α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors, as well as downstream activation of brain-derived neurotrophic factor (BDNF) and mechanistic target of rapamycin (mTOR) signaling pathways to potentiate synaptic plasticity." @default.
- W3156808538 created "2021-04-26" @default.
- W3156808538 creator A5038151589 @default.
- W3156808538 creator A5041783960 @default.
- W3156808538 creator A5056510423 @default.
- W3156808538 creator A5066690712 @default.
- W3156808538 date "2021-06-01" @default.
- W3156808538 modified "2023-10-01" @default.
- W3156808538 title "Ketamine for post-traumatic stress disorders and it's possible therapeutic mechanism" @default.
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