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• W3156886555 abstract "BackgroundRNA vaccines against coronavirus disease 2019 (COVID-19) have demonstrated ∼95% efficacy in phase III clinical trials. Although complete vaccination consisted of 2 doses, the onset of protection for both licensed RNA vaccines was observed as early as 12 days after a single dose. The adaptive immune response that coincides with this onset of protection could represent the necessary elements of immunity against COVID-19.MethodsSerological and T cell analysis was performed in a cohort of 20 healthcare workers after receiving the first dose of the Pfizer/BioNTech BNT162b2 vaccine. The primary endpoint was the adaptive immune responses detectable at days 7 and 10 after dosing.FindingsSpike-specific T cells and binding antibodies were detectable 10 days after the first dose of the vaccine, in contrast to receptor-blocking and severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) neutralizing antibodies, which were mostly undetectable at this early time point.ConclusionsOur findings suggest that early T cell and binding antibody responses, rather than either receptor-blocking or virus neutralizing activity, induced early protection against COVID-19.FundingThe study was funded by a generous donation from The Hour Glass to support COVID-19 research." @default.
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• W3156886555 date "2021-06-01" @default.
• W3156886555 modified "2023-10-17" @default.
• W3156886555 title "Early T cell and binding antibody responses are associated with COVID-19 RNA vaccine efficacy onset" @default.
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• W3156886555 doi "https://doi.org/10.1016/j.medj.2021.04.003" @default.
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