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• W3156892049 endingPage "2022" @default.
• W3156892049 startingPage "2014" @default.
• W3156892049 abstract "Background and aims Familial Hypercholesterolemia (FH) is characterized by elevated LDL-cholesterol (LDL-C) and high atherosclerosis risk. The impact of different dietary patterns on atherosclerosis biomarkers has been poorly studied in FH. This study verified the association of adherence to a Mediterranean diet with biomarkers of dyslipidemia and low-grade inflammation in molecularly proven FH adults from Brazil (BR) and Spain (SP). Methods and results In this cross-sectional study adherence to the Mediterranean diet was assessed by a validated score and generalized estimating equations were used to evaluate its association with plasma LDL-C, apolipoprotein-B (ApoB) and high sensitivity C-reactive protein (hs-CRP) concentrations. We included 92 (mean age 45 years, 58.7% females) and 98 FH individuals (mean age 46.8 years, 60.2% females) respectively from BR and SP. FH causing variants did not differ between countries. LDL-C, ApoB and hs-CRP concentrations were higher in BR than in SP: 179 (135–250) and 161 (133–193) mg/dL; 141 (109–181) and 103 (88–134) mg/dL; and 1.6 (0.8–4.0) and 0.8 (0.4–1.5) mg/L respectively (all p < 0.001). Most of BR had low adherence (n = 77, 83.7%), while the majority of SP were divided into moderate (n = 35, 35.7%) and strong adherence to the Mediterranean diet (n = 37, 37.8%), p < 0.001. There was a significant inverse association of adherence to the Mediterranean diet score with higher LDL-C, ApoB, and hs-CRP after adjusting for socio economic parameters, caloric and fatty acid intakes as well as pharmacological lipid lowering therapies. Conclusions Higher adherence to a Mediterranean diet was associated with better dyslipidemia and low-grade inflammation profiles in FH." @default.
• W3156892049 created "2021-04-26" @default.
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• W3156892049 date "2021-06-01" @default.
• W3156892049 modified "2023-10-16" @default.
• W3156892049 title "Adherence to a Mediterranean diet, dyslipidemia and inflammation in familial hypercholesterolemia" @default.
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• W3156892049 doi "https://doi.org/10.1016/j.numecd.2021.04.006" @default.
• W3156892049 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34039501" @default.
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