FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3156895231> ?p ?o ?g. }

• W3156895231 endingPage "814" @default.
• W3156895231 startingPage "799" @default.
• W3156895231 abstract "Background: Graph theory and connectomics are new techniques for uncovering disease-induced changes in the brain's structural network. Most prior studied have focused on network statistics as biomarkers of disease. However, an emerging body of work involves exploring how the network serves as a conduit for the propagation of disease factors in the brain and has successfully mapped the functional and pathological consequences of disease propagation. In Alzheimer's disease (AD), progressive deposition of misfolded proteins amyloid and tau is well-known to follow fiber projections, under a prion-like trans-neuronal transmission mechanism, through which misfolded proteins cascade along neuronal pathways, giving rise to network spread. Methods: In this review, we survey the state of the art in mathematical modeling of connectome-mediated pathology spread in AD. Then we address several open questions that are amenable to mathematically precise parsimonious modeling of pathophysiological processes, extrapolated to the whole brain. We specifically identify current formal models of how misfolded proteins are produced, aggregate, and disseminate in brain circuits, and attempt to understand how this process leads to stereotyped progression in Alzheimer's and other related diseases. Conclusion: This review serves to unify current efforts in modeling of AD progression that together have the potential to explain observed phenomena and serve as a test-bed for future hypothesis generation and testing in silico. Impact statement Graph theory is a powerful new approach that is transforming the study of brain processes. There do not exist many focused reviews of the subfield of graph modeling of how Alzheimer's and other dementias propagate within the brain network, and how these processes can be mapped mathematically. By providing timely and topical review of this subfield, we fill a critical gap in the community and present a unified view that can serve as an in silico test-bed for future hypothesis generation and testing. We also point to several open and unaddressed questions and controversies that future practitioners can tackle." @default.
• W3156895231 created "2021-04-26" @default.
• W3156895231 creator A5028325717 @default.
• W3156895231 date "2021-12-01" @default.
• W3156895231 modified "2023-10-09" @default.
• W3156895231 title "Graph Models of Pathology Spread in Alzheimer's Disease: An Alternative to Conventional Graph Theoretic Analysis" @default.
• W3156895231 cites W132449613 @default.
• W3156895231 cites W1552315433 @default.
• W3156895231 cites W1558501000 @default.
• W3156895231 cites W1596467522 @default.
• W3156895231 cites W1602322875 @default.
• W3156895231 cites W1901737651 @default.
• W3156895231 cites W1964472291 @default.
• W3156895231 cites W1965420960 @default.
• W3156895231 cites W1967064349 @default.
• W3156895231 cites W1967823816 @default.
• W3156895231 cites W1971032265 @default.
• W3156895231 cites W1971487740 @default.
• W3156895231 cites W1971744915 @default.
• W3156895231 cites W1973319971 @default.
• W3156895231 cites W1974300727 @default.
• W3156895231 cites W1978116973 @default.
• W3156895231 cites W1980076857 @default.
• W3156895231 cites W1981000616 @default.
• W3156895231 cites W1981458288 @default.
• W3156895231 cites W1982674196 @default.
• W3156895231 cites W1983208069 @default.
• W3156895231 cites W1983537704 @default.
• W3156895231 cites W1983750916 @default.
• W3156895231 cites W1985480042 @default.
• W3156895231 cites W1987549963 @default.
• W3156895231 cites W1989208474 @default.
• W3156895231 cites W1989996110 @default.
• W3156895231 cites W1991600017 @default.
• W3156895231 cites W1993191388 @default.
• W3156895231 cites W1995202691 @default.
• W3156895231 cites W1996496731 @default.
• W3156895231 cites W1999653836 @default.
• W3156895231 cites W1999886226 @default.
• W3156895231 cites W2000133863 @default.
• W3156895231 cites W2001704669 @default.
• W3156895231 cites W2002654771 @default.
• W3156895231 cites W2003618511 @default.
• W3156895231 cites W2004341548 @default.
• W3156895231 cites W2005221270 @default.
• W3156895231 cites W2009531026 @default.
• W3156895231 cites W2011634611 @default.
• W3156895231 cites W2011637489 @default.
• W3156895231 cites W2016516944 @default.
• W3156895231 cites W2016787780 @default.
• W3156895231 cites W2019204197 @default.
• W3156895231 cites W2020519533 @default.
• W3156895231 cites W2022175261 @default.
• W3156895231 cites W2022381144 @default.
• W3156895231 cites W2022532556 @default.
• W3156895231 cites W2023986336 @default.
• W3156895231 cites W2024892001 @default.
• W3156895231 cites W2025262281 @default.
• W3156895231 cites W2028974698 @default.
• W3156895231 cites W2030847210 @default.
• W3156895231 cites W2032426886 @default.
• W3156895231 cites W2033672635 @default.
• W3156895231 cites W2034147064 @default.
• W3156895231 cites W2034286717 @default.
• W3156895231 cites W2036223263 @default.
• W3156895231 cites W2037298718 @default.
• W3156895231 cites W2042007687 @default.
• W3156895231 cites W2042396829 @default.
• W3156895231 cites W2042795487 @default.
• W3156895231 cites W2046885195 @default.
• W3156895231 cites W2050786534 @default.
• W3156895231 cites W2052149626 @default.
• W3156895231 cites W2053082937 @default.
• W3156895231 cites W2053116497 @default.
• W3156895231 cites W2054423686 @default.
• W3156895231 cites W2057401494 @default.
• W3156895231 cites W2060240841 @default.
• W3156895231 cites W2062791478 @default.
• W3156895231 cites W2064367582 @default.
• W3156895231 cites W2066904587 @default.
• W3156895231 cites W2067412834 @default.
• W3156895231 cites W2068386340 @default.
• W3156895231 cites W2072928391 @default.
• W3156895231 cites W2073374252 @default.
• W3156895231 cites W2073775320 @default.
• W3156895231 cites W2074274706 @default.
• W3156895231 cites W2075437836 @default.
• W3156895231 cites W2075496760 @default.
• W3156895231 cites W2076220672 @default.
• W3156895231 cites W2076482846 @default.
• W3156895231 cites W2077558463 @default.
• W3156895231 cites W2080816290 @default.
• W3156895231 cites W2082429191 @default.
• W3156895231 cites W2086079444 @default.
• W3156895231 cites W2088079659 @default.
• W3156895231 cites W2088515634 @default.
• W3156895231 cites W2089691915 @default.
• W3156895231 cites W2093103229 @default.

• next