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- W3156931985 abstract "Due to the growing costs of chemotherapy, previous imaging techniques such as MRI or CT scans have become too time-consuming in the assessment of chemotherapy’s effects. With results generated about 2 weeks later, the patient is exposed to the negative side effects of these medications with the possibility that chemotherapy may not be improving their prognosis. Thus, ultrasound has become increasingly popular as a method to determine chemotherapy’s effect on tumors within 24 hours. Both low and high-frequency ultrasound are novel, noninvasive methods for detecting cell death based on changes in cell morphology. Condensation, fragmentation and alterations in the cell nucleus during apoptosis are linked to changes in the cell’s acoustic properties, as indicated by experimental evidence. In this study, quantitative ultrasound was used to follow responses of tumor models to chemotherapy in vivo. As studies have shown that structural changes can occur as early as 24 hours after treatment, ultrasound imaging was administered before and 24 hours after treatment. Changes in ultrasound parameters such as spectral slope, Y-intercept, and midband fit were analyzed relative to pretreatment control data and when compared to changes in the tumors seen through cell staining, changes consistent with cell death were observed." @default.
- W3156931985 created "2021-04-26" @default.
- W3156931985 creator A5076339279 @default.
- W3156931985 date "2018-02-20" @default.
- W3156931985 modified "2023-09-25" @default.
- W3156931985 title "27. Low Frequency Ultrasound Imaging of Apoptosis in Tumor Response: Non-Invasive Monitoring of Chemotherapy Effects" @default.
- W3156931985 doi "https://doi.org/10.24908/iqurcp.9468" @default.
- W3156931985 hasPublicationYear "2018" @default.
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