Matches in SemOpenAlex for { <https://semopenalex.org/work/W3156956055> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W3156956055 abstract "Background Breast cancer is the second leading cause of cancer death in women. There are multiple pathogenic mutations in addition to BRCA1/2 that are implicated in causing hereditary breast cancer. Methods and results We conducted a retrospective analysis of 1568 patients with breast cancer diagnosed between January 1, 2015, and December 31, 2018. The age range is 23-87. Among the study population, 26% had genetic testing and 8% of those were found to carry a pathogenic variant, as designated in NCCN (National Comprehensive Cancer Network) Guidelines. Of that 8%, 3.4% were BRCA1 and BRCA2 mutations, and the rest were other prevalent pathogenic variants. Discussion Expanded panel testing has the potential to increase the detection rate of pathogenic variants compared to testing for BRCA1/2 alone. Diagnostic accuracy of genetic causes of breast cancer has a significant clinical impact on patients and their families in terms of targeted treatment and prevention strategies. There is a strong need for further understanding of genetic patterns and variations in hereditary breast cancer. Awareness of the possibility of moderate to low penetrance genes and variants of uncertain significance (VUS) is important to assist with appropriate genetic counseling. We believe that physicians should consider re-testing with an expanded panel if patients previously had BRCA1 and BRCA2 testings only with a negative result as it may identify additional mutations." @default.
- W3156956055 created "2021-04-26" @default.
- W3156956055 creator A5000618412 @default.
- W3156956055 creator A5015073446 @default.
- W3156956055 creator A5040125766 @default.
- W3156956055 creator A5055366075 @default.
- W3156956055 creator A5056598538 @default.
- W3156956055 creator A5074922101 @default.
- W3156956055 creator A5083505261 @default.
- W3156956055 date "2021-04-22" @default.
- W3156956055 modified "2023-09-27" @default.
- W3156956055 title "Genetic Variation and the Role of Multigene Panel Testing for Hereditary Breast Cancer: A Single-Institution Experience" @default.
- W3156956055 cites W1871202334 @default.
- W3156956055 cites W2000870557 @default.
- W3156956055 cites W2052716173 @default.
- W3156956055 cites W2105493883 @default.
- W3156956055 cites W2106542343 @default.
- W3156956055 cites W2152179896 @default.
- W3156956055 cites W2224210111 @default.
- W3156956055 cites W2422231209 @default.
- W3156956055 cites W2598515088 @default.
- W3156956055 cites W2605106553 @default.
- W3156956055 cites W2761677994 @default.
- W3156956055 cites W2902403392 @default.
- W3156956055 cites W2905048441 @default.
- W3156956055 cites W2990275766 @default.
- W3156956055 cites W2991376102 @default.
- W3156956055 cites W2992387662 @default.
- W3156956055 cites W2994453028 @default.
- W3156956055 doi "https://doi.org/10.7759/cureus.14637" @default.
- W3156956055 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8140759" @default.
- W3156956055 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34046273" @default.
- W3156956055 hasPublicationYear "2021" @default.
- W3156956055 type Work @default.
- W3156956055 sameAs 3156956055 @default.
- W3156956055 citedByCount "0" @default.
- W3156956055 crossrefType "journal-article" @default.
- W3156956055 hasAuthorship W3156956055A5000618412 @default.
- W3156956055 hasAuthorship W3156956055A5015073446 @default.
- W3156956055 hasAuthorship W3156956055A5040125766 @default.
- W3156956055 hasAuthorship W3156956055A5055366075 @default.
- W3156956055 hasAuthorship W3156956055A5056598538 @default.
- W3156956055 hasAuthorship W3156956055A5074922101 @default.
- W3156956055 hasAuthorship W3156956055A5083505261 @default.
- W3156956055 hasBestOaLocation W31569560551 @default.
- W3156956055 hasConcept C104317684 @default.
- W3156956055 hasConcept C121608353 @default.
- W3156956055 hasConcept C126322002 @default.
- W3156956055 hasConcept C127716648 @default.
- W3156956055 hasConcept C143998085 @default.
- W3156956055 hasConcept C200544954 @default.
- W3156956055 hasConcept C2780673598 @default.
- W3156956055 hasConcept C2908647359 @default.
- W3156956055 hasConcept C530470458 @default.
- W3156956055 hasConcept C54355233 @default.
- W3156956055 hasConcept C60644358 @default.
- W3156956055 hasConcept C71924100 @default.
- W3156956055 hasConcept C80227256 @default.
- W3156956055 hasConcept C86803240 @default.
- W3156956055 hasConcept C99454951 @default.
- W3156956055 hasConceptScore W3156956055C104317684 @default.
- W3156956055 hasConceptScore W3156956055C121608353 @default.
- W3156956055 hasConceptScore W3156956055C126322002 @default.
- W3156956055 hasConceptScore W3156956055C127716648 @default.
- W3156956055 hasConceptScore W3156956055C143998085 @default.
- W3156956055 hasConceptScore W3156956055C200544954 @default.
- W3156956055 hasConceptScore W3156956055C2780673598 @default.
- W3156956055 hasConceptScore W3156956055C2908647359 @default.
- W3156956055 hasConceptScore W3156956055C530470458 @default.
- W3156956055 hasConceptScore W3156956055C54355233 @default.
- W3156956055 hasConceptScore W3156956055C60644358 @default.
- W3156956055 hasConceptScore W3156956055C71924100 @default.
- W3156956055 hasConceptScore W3156956055C80227256 @default.
- W3156956055 hasConceptScore W3156956055C86803240 @default.
- W3156956055 hasConceptScore W3156956055C99454951 @default.
- W3156956055 hasLocation W31569560551 @default.
- W3156956055 hasLocation W31569560552 @default.
- W3156956055 hasOpenAccess W3156956055 @default.
- W3156956055 hasPrimaryLocation W31569560551 @default.
- W3156956055 hasRelatedWork W2023425329 @default.
- W3156956055 hasRelatedWork W2108073931 @default.
- W3156956055 hasRelatedWork W2149053319 @default.
- W3156956055 hasRelatedWork W2723088909 @default.
- W3156956055 hasRelatedWork W2898303543 @default.
- W3156956055 hasRelatedWork W2945981099 @default.
- W3156956055 hasRelatedWork W2994453028 @default.
- W3156956055 hasRelatedWork W3183151532 @default.
- W3156956055 hasRelatedWork W3192357491 @default.
- W3156956055 hasRelatedWork W373552583 @default.
- W3156956055 isParatext "false" @default.
- W3156956055 isRetracted "false" @default.
- W3156956055 magId "3156956055" @default.
- W3156956055 workType "article" @default.