Matches in SemOpenAlex for { <https://semopenalex.org/work/W31569885> ?p ?o ?g. }
- W31569885 abstract "Neuroblastoma (NBL) is the most common extracranial pediatric solid tumor and has heterogeneous biology and behavior. Patients with high-risk disease have poor prognosis despite complex multimodal therapy; therefore, novel curative approaches are needed. Immunotherapy is a novel therapeutic approach that harnesses the inherent activity of the immune system to control and eliminate malignant cells. One form of immunotherapy uses chimeric antigen receptors (CAR) to target tumor-associated antigens. CARs are derived from the antigen-binding domain of a monoclonal antibody (MAb) coupled with the intracellular signaling portion of the T cell receptor. CARs can combine the specificity and effectiveness of MAbs with the active bio-distribution, direct cytotoxicity, and long-term persistence of T cells. NBL provides an attractive target for CAR immunotherapy as many of its tumor-associated antigens are not expressed at significant levels on normal tissues, thus decreasing potential treatment related toxicity. Two previous clinical trials utilizing L1-cell adhesion molecule (L1-CAM) and disialoganglioside (GD2) specific CARs (GD2-CAR) have demonstrated safety and anti-tumor efficacy in heavily pretreated relapsed/refractory neuroblastoma patients. Based on these promising results and on improved techniques that can further potentiate CAR therapies, two clinical trials are currently investigating the use of GD2-CARs in children with NBL. Several approaches may further enhance anti-tumor activity and persistence of CAR modified cells, and if these can be safely translated into the clinic, CAR-based immunotherapy could become a viable adjunct or potential alternative to conventional treatment options for patients with NBL." @default.
- W31569885 created "2016-06-24" @default.
- W31569885 creator A5041658971 @default.
- W31569885 creator A5065594317 @default.
- W31569885 date "2013-12-01" @default.
- W31569885 modified "2023-09-23" @default.
- W31569885 title "Advances in chimeric antigen receptor immunotherapy for neuroblastoma." @default.
- W31569885 cites W1523753658 @default.
- W31569885 cites W1583511232 @default.
- W31569885 cites W1614553858 @default.
- W31569885 cites W1776095166 @default.
- W31569885 cites W1937240592 @default.
- W31569885 cites W1967139222 @default.
- W31569885 cites W1970218502 @default.
- W31569885 cites W1970867883 @default.
- W31569885 cites W1971736106 @default.
- W31569885 cites W1975193662 @default.
- W31569885 cites W1975381332 @default.
- W31569885 cites W1979593849 @default.
- W31569885 cites W1980422222 @default.
- W31569885 cites W1984287161 @default.
- W31569885 cites W1985789005 @default.
- W31569885 cites W1986294131 @default.
- W31569885 cites W1993954120 @default.
- W31569885 cites W1995515999 @default.
- W31569885 cites W1999843922 @default.
- W31569885 cites W2002387731 @default.
- W31569885 cites W2003197307 @default.
- W31569885 cites W2005354199 @default.
- W31569885 cites W2009607549 @default.
- W31569885 cites W2009709218 @default.
- W31569885 cites W2020312840 @default.
- W31569885 cites W2023239509 @default.
- W31569885 cites W2024120152 @default.
- W31569885 cites W2034769339 @default.
- W31569885 cites W2036288301 @default.
- W31569885 cites W2045228092 @default.
- W31569885 cites W2058959863 @default.
- W31569885 cites W2064510700 @default.
- W31569885 cites W2065438642 @default.
- W31569885 cites W2066214953 @default.
- W31569885 cites W2067650601 @default.
- W31569885 cites W2068890283 @default.
- W31569885 cites W2086135567 @default.
- W31569885 cites W2087055812 @default.
- W31569885 cites W2087134443 @default.
- W31569885 cites W2091246599 @default.
- W31569885 cites W2094652659 @default.
- W31569885 cites W2094945699 @default.
- W31569885 cites W2101653483 @default.
- W31569885 cites W2117321078 @default.
- W31569885 cites W2122465970 @default.
- W31569885 cites W2130011407 @default.
- W31569885 cites W2130338247 @default.
- W31569885 cites W2130465135 @default.
- W31569885 cites W2141410122 @default.
- W31569885 cites W2143163879 @default.
- W31569885 cites W2144436556 @default.
- W31569885 cites W2144999788 @default.
- W31569885 cites W2148360952 @default.
- W31569885 cites W2151310238 @default.
- W31569885 cites W2158186400 @default.
- W31569885 cites W2160834915 @default.
- W31569885 cites W2167550136 @default.
- W31569885 cites W2275486956 @default.
- W31569885 cites W2323539794 @default.
- W31569885 cites W2327522594 @default.
- W31569885 cites W2395745227 @default.
- W31569885 cites W2406723506 @default.
- W31569885 cites W49395982 @default.
- W31569885 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4106238" @default.
- W31569885 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24333408" @default.
- W31569885 hasPublicationYear "2013" @default.
- W31569885 type Work @default.
- W31569885 sameAs 31569885 @default.
- W31569885 citedByCount "12" @default.
- W31569885 countsByYear W315698852015 @default.
- W31569885 countsByYear W315698852016 @default.
- W31569885 countsByYear W315698852017 @default.
- W31569885 countsByYear W315698852018 @default.
- W31569885 countsByYear W315698852019 @default.
- W31569885 crossrefType "journal-article" @default.
- W31569885 hasAuthorship W31569885A5041658971 @default.
- W31569885 hasAuthorship W31569885A5065594317 @default.
- W31569885 hasConcept C126322002 @default.
- W31569885 hasConcept C147483822 @default.
- W31569885 hasConcept C159654299 @default.
- W31569885 hasConcept C203014093 @default.
- W31569885 hasConcept C2776715637 @default.
- W31569885 hasConcept C2777701055 @default.
- W31569885 hasConcept C2780674031 @default.
- W31569885 hasConcept C3875195 @default.
- W31569885 hasConcept C502942594 @default.
- W31569885 hasConcept C535046627 @default.
- W31569885 hasConcept C542903549 @default.
- W31569885 hasConcept C54355233 @default.
- W31569885 hasConcept C71924100 @default.
- W31569885 hasConcept C81885089 @default.
- W31569885 hasConcept C86803240 @default.
- W31569885 hasConcept C8891405 @default.