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- W3157007989 endingPage "622" @default.
- W3157007989 startingPage "622" @default.
- W3157007989 abstract "Silencing of tumor suppressor genes (TSGs) through epigenetic mechanisms, mainly via abnormal promoter DNA methylation, is considered a main mechanism of tumorigenesis. The abnormal DNA methylation profiles are transmitted from the cancer mother cell to the daughter cells through the involvement of a macromolecular complex in which the ubiquitin-like containing plant homeodomain (PHD), and an interesting new gene (RING) finger domains 1 (UHRF1), play the role of conductor. Indeed, UHRF1 interacts with epigenetic writers, such as DNA methyltransferase 1 (DNMT1), histone methyltransferase G9a, erasers like histone deacetylase 1 (HDAC1), and functions as a hub protein. Thus, targeting UHRF1 and/or its partners is a promising strategy for epigenetic cancer therapy. The natural compound thymoquinone (TQ) exhibits anticancer activities by targeting several cellular signaling pathways, including those involving UHRF1. In this review, we highlight TQ as a potential multitarget single epidrug that functions by targeting the UHRF1/DNMT1/HDAC1/G9a complex. We also speculate on the possibility that TQ might specifically target UHRF1, with subsequent regulatory effects on other partners." @default.
- W3157007989 created "2021-04-26" @default.
- W3157007989 creator A5007797318 @default.
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- W3157007989 creator A5042745837 @default.
- W3157007989 creator A5048253653 @default.
- W3157007989 creator A5086147319 @default.
- W3157007989 date "2021-04-22" @default.
- W3157007989 modified "2023-09-25" @default.
- W3157007989 title "Thymoquinone Is a Multitarget Single Epidrug That Inhibits the UHRF1 Protein Complex" @default.
- W3157007989 cites W1580264876 @default.
- W3157007989 cites W1742190155 @default.
- W3157007989 cites W1920711459 @default.
- W3157007989 cites W1945080129 @default.
- W3157007989 cites W1964114393 @default.
- W3157007989 cites W1968165842 @default.
- W3157007989 cites W1971978509 @default.
- W3157007989 cites W1972169216 @default.
- W3157007989 cites W1976535708 @default.
- W3157007989 cites W1977063334 @default.
- W3157007989 cites W1977567422 @default.
- W3157007989 cites W1985459563 @default.
- W3157007989 cites W1986362431 @default.
- W3157007989 cites W1988102584 @default.
- W3157007989 cites W1988573625 @default.
- W3157007989 cites W1990238517 @default.
- W3157007989 cites W1992304577 @default.
- W3157007989 cites W1992598609 @default.
- W3157007989 cites W1997175592 @default.
- W3157007989 cites W1998883376 @default.
- W3157007989 cites W1999952393 @default.
- W3157007989 cites W2006696807 @default.
- W3157007989 cites W2011098594 @default.
- W3157007989 cites W2012283922 @default.
- W3157007989 cites W2014071036 @default.
- W3157007989 cites W2017996739 @default.
- W3157007989 cites W2019967976 @default.
- W3157007989 cites W2020682101 @default.
- W3157007989 cites W2027171343 @default.
- W3157007989 cites W2030509991 @default.
- W3157007989 cites W2031630499 @default.
- W3157007989 cites W2034325228 @default.
- W3157007989 cites W2036030151 @default.
- W3157007989 cites W2037385288 @default.
- W3157007989 cites W2037586946 @default.
- W3157007989 cites W2039226560 @default.
- W3157007989 cites W2044219470 @default.
- W3157007989 cites W2045951374 @default.
- W3157007989 cites W2051248464 @default.
- W3157007989 cites W2054639072 @default.
- W3157007989 cites W2056653443 @default.
- W3157007989 cites W2057134657 @default.
- W3157007989 cites W2059249241 @default.
- W3157007989 cites W2060117969 @default.
- W3157007989 cites W2062540888 @default.
- W3157007989 cites W2064522668 @default.
- W3157007989 cites W2070170487 @default.
- W3157007989 cites W2075222802 @default.
- W3157007989 cites W2075625882 @default.
- W3157007989 cites W2079621764 @default.
- W3157007989 cites W2080332548 @default.
- W3157007989 cites W2080515794 @default.
- W3157007989 cites W2085667285 @default.
- W3157007989 cites W2092067905 @default.
- W3157007989 cites W2092293354 @default.
- W3157007989 cites W2092809409 @default.
- W3157007989 cites W2096083625 @default.
- W3157007989 cites W2097445414 @default.
- W3157007989 cites W2099407732 @default.
- W3157007989 cites W2100281006 @default.
- W3157007989 cites W2101451323 @default.
- W3157007989 cites W2101659982 @default.
- W3157007989 cites W2115924401 @default.
- W3157007989 cites W2116851173 @default.
- W3157007989 cites W2117809535 @default.
- W3157007989 cites W2121264387 @default.
- W3157007989 cites W2122557087 @default.
- W3157007989 cites W2122706742 @default.
- W3157007989 cites W2122951345 @default.
- W3157007989 cites W2123789470 @default.
- W3157007989 cites W2124086839 @default.
- W3157007989 cites W2125027849 @default.
- W3157007989 cites W2129262211 @default.
- W3157007989 cites W2131612302 @default.
- W3157007989 cites W2138421443 @default.
- W3157007989 cites W2141410747 @default.
- W3157007989 cites W2142745453 @default.
- W3157007989 cites W2146259423 @default.
- W3157007989 cites W2150205536 @default.
- W3157007989 cites W2150642119 @default.
- W3157007989 cites W2154471713 @default.
- W3157007989 cites W2155504720 @default.
- W3157007989 cites W2155631307 @default.
- W3157007989 cites W2155725346 @default.
- W3157007989 cites W2156559492 @default.
- W3157007989 cites W2157423592 @default.
- W3157007989 cites W2180661013 @default.